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> Methenamine (hippurate) [5714-73-8]

Methenamine (hippurate) [5714-73-8]

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Cat# HY-B1691-100mg

Size : 100mg

Brand : MedChemExpress

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Description

Methenamine hippurate (Hexamine hippurate) is an orally active urinary antiseptic agent with a wide antibacterial spectrum. Methenamine hippurate is effective against most common urinary tract pathogens[1][2].

In Vitro

Methenamine hippurate is a urinary antibacterial agent which releases formaldehyde and is excreted in the urine. Methenamine hippurate has a demonstrable activity in vitro at pH 5 to 6 against Escherichia coli, Staphylococcus aureus, Aerobacter aeroaenes, Pseudomonas aeruginosa and Proteus vulgaris, and a wide range of action against Klebsiella pneumoniae, Ps. aeruginosa, E. coli, Staph. aureus and Streptococcus haemolytic at pH of 7.4. This action is more effective than that of Methenamine alone, of Hippuric acid alone or of Sulphadiazine[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Methenamine hippurate Related Antibodies

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (313.13 mM; Need ultrasonic)

DMSO : 25 mg/mL (78.28 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1313 mL 15.6563 mL 31.3126 mL
5 mM 0.6263 mL 3.1313 mL 6.2625 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (313.13 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References