KS15
Cat# AOB17572-25
Size : 25mg
Brand : AOBIOUS
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Data sheet
| Molecular Formula | C20H22BrNO4 |
| Molecular Weight | 420.30 |
| CAS Numbers | 1033781-20-2 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| Synonym | KS15; KS 15; KS-15 |
| IUPAC/Chemical Name | (R,E)-3-(3-(1-(((4-Bromobenzyl)oxy)imino)ethyl)phenyl)-2-ethoxypropanoic acid |
| InChl Key | GWSVRVKPZVYTCS-VZMFNRANSA-N |
| InChl Code | InChI=1S/C20H22BrNO4/c1-3-25-19(20(23)24)12-16-5-4-6-17(11-16)14(2)22-26-13-15-7-9-18(21)10-8-15/h4-11,19H,3,12-13H2,1-2H3,(H,23,24)/b22-14+/t19-/m1/s1 |
| SMILES Code | O=C(O)[C@H](OCC)CC1=CC=CC(/C(C)=N/OCC2=CC=C(Br)C=C2)=C1 |
| References | 1) Jang J, Chung S, Choi Y, Lim HY, Son Y, Chun SK, Son GH, Kim K, Suh YG, Jung JW. The cryptochrome inhibitor KS15 enhances E-box-mediated transcription by disrupting the feedback action of a circadian transcription-repressor complex. Life Sci. 2018 May 1;200:49-55. 2) Zhu Z, Yang F, Chen P, Liu H, Cao W, Zhang K, Liu X, Zheng H. Emergence of novel Seneca Valley virus strains in China, 2017. Transbound Emerg Dis. 2017 Aug;64(4):1024-1029. 3) Chun SK, Chung S, Kim HD, Lee JH, Jang J, Kim J, Kim D, Son GH, Oh YJ, Suh YG, Lee CS, Kim K. A synthetic cryptochrome inhibitor induces anti-proliferative effects and increases chemosensitivity in human breast cancer cells. Biochem Biophys Res Commun. 2015 Nov 13;467(2):441-6. |
More info
Novel cryptochrome (CRY) inhibitor, enhancing E-box-mediated transcription by disrupting the feedback action of a circadian transcription-repressor complex.