- More Files
- Specifications
Product Description
Mouse monoclonal antibody raised against native ITGB1.
Immunogen
Native purified ITGB1 from Raji Burkitt's lymphoma cell line.
Host
Mouse
Theoretical MW (kDa)
130
Reactivity
Dog, Human, Pig
Specificity
This antibody reacts with CD29 (integrin beta1 chain), a 130 KDa single chain type I glycoprotein expressed as a heterodimer (non-covalently associated with the integrin alpha subunits 1-6).
Form
Liquid
Conjugation
FITC
Isotype
IgG1
Recommend Usage
Flow Cytometry (20 ul in human blood cells 100 ul in whole blood or 106 cells in a suspension)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.2% BSA, 0.09% sodium azide)
Storage Instruction
Store in the dark at 4°C. Do not freeze.
Avoid prolonged exposure to light.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Applications
Flow Cytometry
- Gene Info — ITGB1
Entrez GeneID
3688Gene Name
ITGB1
Gene Alias
CD29, FNRB, GPIIA, MDF2, MSK12, VLA-BETA, VLAB
Gene Description
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
Omim ID
135630Gene Ontology
HyperlinkGene Summary
Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. This gene encodes a beta subunit. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000019420|OTTHUMP00000046253|OTTHUMP00000063731|OTTHUMP00000063732|OTTHUMP00000063733|fibronectin receptor beta subunit|integrin VLA-4 beta subunit|integrin beta 1
- Interactomes
- Pathways
- Diseases
- Publication Reference
- Arf and Rho GAP adapter protein ARAP1 participates in the mobilization of TRAIL-R1/DR4 to the plasma membrane.
Simova S, Klima M, Cermak L, Sourkova V, Andera L.
Apoptosis 2008 Mar; 13(3):423.
- The role of beta1 integrin subfamily in anchorage-dependent apoptosis of breast carcinoma cells differing in multidrug resistance.
Morozevich GE, Kozlova NI, Preobrazhenskaya ME, Ushakova NA, Eltsov IA, Shtil AA, Berman AE.
Biochemistry 2006 May; 71(5):489.
- Integrin alpha2beta1 regulates neutrophil recruitment and inflammatory activity in experimental colitis in mice.
Lundberg S, Lindholm J, Lindbom L, Hellstrom PM, Werr J.
Inflammatory Bowel Diseases 2006 Mar; 12(3):172.
- Arf and Rho GAP adapter protein ARAP1 participates in the mobilization of TRAIL-R1/DR4 to the plasma membrane.