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IBMX [28822-58-4]

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Cat# 10-1008-100mg

Size : 100mg

Brand : Focus Biomolecules

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IBMX | PDE inhibitor

CAS:
28822-58-4
Catalog Number:
10-1008
Activity:
PDE inhibitor
Alternate Names:
3-Isobutyl-1-methylxanthine
Chemical Name:
3,7-Dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione
Molecular Weight:
222.25
Molecular Formula:
C10H14N4O2
Solubility:
Soluble in DMSO (up to 15 mg/ml) or in Ethanol (up to 10 mg/ml).
Physical Properties:
White solid
Purity:
99% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

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100 mg$36.00
1 Gram$155.00
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IBMX (28822-58-4) is a pan-specific inhibitor of phosphodiesterases (IC50=2-50 µM). Inhibition of PDEs leads to increased concentration of intracellular cAMP which activates PKA.2 IBMX does not inhibit PDE8 or PDE9.3 Weak adenosine receptor antagonist.4

References/Citations:

1) Beavo et al. (1970), Effects of xanthine derivatives on lipolysis and on adenosine 3′,5′-monophosphate phosphodiesterase activity; Mol. Pharmacol., 6 597
2) Tomes et al. (1993), Isobutylmethylxanthine and other classical cyclic nucleotide phosphodiesterase inhibitors affect cAMP-dependent protein kinase activity; Cell Signal., 5 615
3) Soderling et al. (2000), Regulation of cAMP and cGMP signaling: new phosphodiesterases and new functions; Curr. Opin. Cell Biol., 12 174
4) Daly et al. (1987), Adenosine receptors: development of selective agonists and antagonists; Prog. Clin. Biol. Res., 230 41

CAS:
28822-58-4
Catalog Number:
10-1008
Activity:
PDE inhibitor
Alternate Names:
3-Isobutyl-1-methylxanthine
Chemical Name:
3,7-Dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione
Molecular Weight:
222.25
Molecular Formula:
C10H14N4O2
Solubility:
Soluble in DMSO (up to 15 mg/ml) or in Ethanol (up to 10 mg/ml).
Physical Properties:
White solid
Purity:
99% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

Download Safety Data Sheet

Product Data Sheet:

Download Product Data Sheet

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a restocking/refund fee

IBMX (28822-58-4) is a pan-specific inhibitor of phosphodiesterases (IC50=2-50 µM). Inhibition of PDEs leads to increased concentration of intracellular cAMP which activates PKA.2 IBMX does not inhibit PDE8 or PDE9.3 Weak adenosine receptor antagonist.4

References/Citations:

1) Beavo et al. (1970), Effects of xanthine derivatives on lipolysis and on adenosine 3′,5′-monophosphate phosphodiesterase activity; Mol. Pharmacol., 6 597
2) Tomes et al. (1993), Isobutylmethylxanthine and other classical cyclic nucleotide phosphodiesterase inhibitors affect cAMP-dependent protein kinase activity; Cell Signal., 5 615
3) Soderling et al. (2000), Regulation of cAMP and cGMP signaling: new phosphodiesterases and new functions; Curr. Opin. Cell Biol., 12 174
4) Daly et al. (1987), Adenosine receptors: development of selective agonists and antagonists; Prog. Clin. Biol. Res., 230 41

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