Human ABCC11 (ATP Binding Cassette Transporter C11) Sandwich ELISA Kit

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	ABCC11
Gene ID:	85320
Uniprot ID:	MRP8_HUMAN
Sample Type:	tissue homogenates, cell lysates or other biological fluids.

Tissue Specificity	Expressed in ceruminous apocrine gland (at protein level). Expressed in many tissues. Not expressed in kidney, spleen and colon. Highly expressed in breast cancer. Expressed at moderate levels in normal breast and testis and at very low levels in liver, brain and placenta. Localizes to axons of the CNS and peripheral nervous system (at protein level).
Post Translational Modifications
Function	ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Participates in physiological processes involving bile acids, conjugated steroids and cyclic nucleotides. Stimulates the ATP-dependent uptake of a range of physiological lipophilic anions, including the glutathione S-conjugates leukotriene C4 and dinitrophenyl S-glutathione, steroid sulfates such as dehydroepiandrosterone 3-sulfate (DHEAS) and estrone 3-sulfate, glucuronides such as estradiol 17-beta-D-glucuronide (E(2)17betaG), the monoanionic bile acids glycocholate and taurocholate, and methotrexate. Enhances also the cellular extrusion of cAMP and cGMP. Confers resistance to anticancer drugs, such as 5-fluorouracil (5-FU) and methotrexate. Probably functions to secrete earwax. Required for the secretion of components contributing to axillary odor formation.
Protein Name	Atp-Binding Cassette Sub-Family C Member 11 Multidrug Resistance-Associated Protein 8
Database Links	Reactome: R-HSA-382556
Cellular Localisation	Cell Membrane Multi-Pass Membrane Protein Vacuole Membrane Cytoplasmic Vesicle Membrane Apical Cell Membrane
Alternative ELISA Names	Atp-Binding Cassette Sub-Family C Member 11 ELISA kit Multidrug Resistance-Associated Protein 8 ELISA kit ABCC11 ELISA kit MRP8 ELISA kit
output

Information sourced from Uniprot.org

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