Ganetespib [888216-25-9]
Cat# HY-15205-5mg
Size : 5mg
Brand : MedChemExpress
Ganetespib (STA-9090) is a heat shock protein 90 (HSP90) inhibitor which exhibits potent cytotoxicity in a wide variety of hematological and solid tumor cell lines. Ganetespib has antiangiogenic effects in colorectal cancer mediated through inhibition of HIF-1α and STAT3.
For research use only. We do not sell to patients.
Ganetespib Chemical Structure
CAS No. : 888216-25-9
This product is a controlled substance and not for sale in your territory.
Based on 40 publication(s) in Google Scholar
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Ganetespib purchased from MedChemExpress. Usage Cited in: Int J Biochem Cell Biol. 2019 Jan;106:35-45. [Abstract]
- Levels of HSP70, and phosphorylation and total protein of p38, ERK, JNK, JAK2, STAT3, IκB-α and p65 in total cell lysates are analysed using Western blotting with or without ganetespib (100 nM).
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Ganetespib purchased from MedChemExpress. Usage Cited in: Int J Biochem Cell Biol. 2019 Jan;106:35-45. [Abstract]
- Confocal immunofluorescence microscopy is performed on cultures that are immunoreacted with antibodies against HSP90β and phospho-Tyr705-STAT3 at 6-h recovery after heat shock with or without ganetespib (100 nM) and HSP90β esiRNA.
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Ganetespib purchased from MedChemExpress. Usage Cited in: Anticancer Res. 2019 Apr;39(4):1767-1775. [Abstract]
- Ganetespib suppresses epidermal growth factor receptor (EGFR) and its related downstream pathway molecules in non-small cell lung cancer cells with acquired resistance to EGFR-tyrosine kinase inhibitor. Cells are treated with the indicated concentration of ganetespib for 24 h, and lysates were analyzed by western blot. AKT: protein kinase B; EMT: epithelial-mesenchymal transition; MET: met proto-oncogene; amp: amplification; MAPK: mitogen-activated protein kinase.
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Ganetespib purchased from MedChemExpress. Usage Cited in: Cancer Cell. 2018 Sep 10;34(3):411-426.e19. [Abstract]
- Immunoblot of HSP70 expression in RD cells after treatment with Ganetespib (GSP) alone or CPT-11+NSC-67574.
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Ganetespib purchased from MedChemExpress. Usage Cited in: Cell Stress Chaperones. 2018 Sep;23(5):1137-1142. [Abstract]
- Western blot analysis of human bladder cancer cell lysates (T24) treated with DMSO, the Hsp90 inhibitor STA9090, the Hsp70 inhibitors VER155008, and MAL3-101 or combinations of the various inhibitors. The blot is probed with a keratin 9 mouse monoclonal antibody
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Ganetespib purchased from MedChemExpress. Usage Cited in: Massachusetts Institute of Technology, University of Texas at Dallas. 2018 Jun.
- Immunoblot of HEK293T-REx cells inducibly expressing dn-cHSF1 following pretreatment with vehicle or dox (18 h; 1 pg/mL) and then HSR activation by treatment with arsenite (6 h; 100 pM) or STA-9090 (6 h; 100 nM).
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Ganetespib purchased from MedChemExpress. Usage Cited in: Massachusetts Institute of Technology, University of Texas at Dallas. 2018 Jun.
- Immunoblot of HEK293T-Rex cells upon treatment with increasing concentrations of the HSP90 inhibitor STA-9090.
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Ganetespib purchased from MedChemExpress. Usage Cited in: ACS Chem Biol. 2016 Jan 15;11(1):200-10. [Abstract]
- Protein level by immunoblotting for HSR target proteins.
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Ganetespib purchased from MedChemExpress. Usage Cited in: Sci Rep. 2015 Aug 3;5:12728. [Abstract]
- Ganetespib decreases the DYRK1A protein level. 293T cells are transiently transfected with an expression vector for 3xFLAG-DYRK1A. At 24 h after transfection, the cells are treated with Ganetespib (100 nM) and collected 0 and 8 h after treatment. Total cell lysates are subjected to SDS-PAGE followed by Western blot analysis using antibodies against FLAG and GAPDH. In the control group (DMSO), expression of 3xFLAG-DYRK1A increases at 8 h compared to 0 h, and Ganetespib suppresses this increase of
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Ganetespib purchased from MedChemExpress. Usage Cited in: Oncotarget. 2015 Nov 24;6(37):39821-38. [Abstract]
- J82 cells are treated with 1 μM STA9090 and 50 μM VER155008 as mono or dual therapy for the time indicated. Lysates are prepared and Western blots probed for cell cycle markers.