Fluphenazine (dihydrochloride) [146-56-5]
Cat# HY-A0081-100mg
Size : 100mg
Brand : MedChemExpress
Fluphenazine dihydrochloride is a potent, orally active phenothiazine-based dopamine receptor antagonist. Fluphenazine dihydrochloride blocks neuronal voltage-gated sodium channels. Fluphenazine dihydrochloride acts primarily through antagonism of postsynaptic dopamine-2 receptors in mesolimbic, nigrostriatal, and tuberoinfundibular neural pathways. Fluphenazine dihydrochloride can antagonize Methylphenidate-induced stereotyped gnawing and inhibit climbing behaviour in mice. Fluphenazine dihydrochloride can be used for researching psychosis and painful peripheral neuropathy associated with diabetes and has potential to inhibit SARS-CoV-2.
For research use only. We do not sell to patients.
Fluphenazine dihydrochloride Chemical Structure
CAS No. : 146-56-5
This product is a controlled substance and not for sale in your territory.
Based on 1 publication(s) in Google Scholar
Other Forms of Fluphenazine dihydrochloride:
- Fluphenazine-d8 dihydrochloride In-stock
- Fluphenazine decanoate In-stock
- Fluphenazine Get quote
- Fluphenazine dimaleate Get quote
View All Dopamine Receptor Isoform Specific Products:
View All Sodium Channel Isoform Specific Products:
Description |
Fluphenazine dihydrochloride is a potent, orally active phenothiazine-based dopamine receptor antagonist. Fluphenazine dihydrochloride blocks neuronal voltage-gated sodium channels. Fluphenazine dihydrochloride acts primarily through antagonism of postsynaptic dopamine-2 receptors in mesolimbic, nigrostriatal, and tuberoinfundibular neural pathways. Fluphenazine dihydrochloride can antagonize Methylphenidate-induced stereotyped gnawing and inhibit climbing behaviour in mice. Fluphenazine dihydrochloride can be used for researching psychosis and painful peripheral neuropathy associated with diabetes and has potential to inhibit SARS-CoV-2[1][2][3][4][6]. |
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In Vivo |
Fluphenazine (1 mg/kg; IG, treated from day 6 to day 15 of gestation) dihydrochloride causes malformations in pregnant mice[5]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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Clinical Trial |
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Molecular Weight |
510.44 |
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Formula |
C22H28Cl2F3N3OS |
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CAS No. |
146-56-5 |
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Appearance |
Solid |
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Color |
White to off-white |
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SMILES |
OCCN1CCN(CCCN2C3=C(C=CC=C3)SC4=CC=C(C(F)(F)F)C=C24)CC1.12Cl.12Cl |
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Shipping | Room temperature in continental US; may vary elsewhere. |
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Storage |
-20°C, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen) |
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Solvent & Solubility |
In Vitro:
H2O : 100 mg/mL (195.91 mM; Need ultrasonic) DMSO : ≥ 38 mg/mL (74.45 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) *"≥" means soluble, but saturation unknown. Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
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Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles. * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
For the following dissolution methods, please prepare the working solution directly.
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration:
mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
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Purity & Documentation |
Purity: 99.89% |
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References |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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DMSO / H2O | 1 mM | 1.9591 mL | 9.7955 mL | 19.5909 mL | 48.9774 mL |
5 mM | 0.3918 mL | 1.9591 mL | 3.9182 mL | 9.7955 mL | |
10 mM | 0.1959 mL | 0.9795 mL | 1.9591 mL | 4.8977 mL | |
15 mM | 0.1306 mL | 0.6530 mL | 1.3061 mL | 3.2652 mL | |
20 mM | 0.0980 mL | 0.4898 mL | 0.9795 mL | 2.4489 mL | |
25 mM | 0.0784 mL | 0.3918 mL | 0.7836 mL | 1.9591 mL | |
30 mM | 0.0653 mL | 0.3265 mL | 0.6530 mL | 1.6326 mL | |
40 mM | 0.0490 mL | 0.2449 mL | 0.4898 mL | 1.2244 mL | |
50 mM | 0.0392 mL | 0.1959 mL | 0.3918 mL | 0.9795 mL | |
60 mM | 0.0327 mL | 0.1633 mL | 0.3265 mL | 0.8163 mL | |
H2O | 80 mM | 0.0245 mL | 0.1224 mL | 0.2449 mL | 0.6122 mL |
100 mM | 0.0196 mL | 0.0980 mL | 0.1959 mL | 0.4898 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Fluphenazine dihydrochloride Related Classifications
- GPCR/G Protein Neuronal Signaling Anti-infection Membrane Transporter/Ion Channel
- Dopamine Receptor SARS-CoV Sodium Channel