Fibrinogen Binding Inhibitor Peptide [89105-94-2]
Cat# HY-P1507-1mg
Size : 1mg
Brand : MedChemExpress
Fibrinogen Binding Inhibitor Peptide is a dodecapeptide (HHLGGAKQAGDV, H12), which is a fibrinogen γ-chain carboxy-terminal sequence (γ400-411). Fibrinogen Binding Inhibitor Peptide is a specific binding site of the ligand for activated glycoprotein (GP) IIb/IIIa.
For research use only. We do not sell to patients.
Custom Peptide Synthesis
Fibrinogen Binding Inhibitor Peptide Chemical Structure
CAS No. : 89105-94-2
This product is a controlled substance and not for sale in your territory.
Based on 1 publication(s) in Google Scholar
Description |
Fibrinogen Binding Inhibitor Peptide is a dodecapeptide (HHLGGAKQAGDV, H12), which is a fibrinogen γ-chain carboxy-terminal sequence (γ400-411). Fibrinogen Binding Inhibitor Peptide is a specific binding site of the ligand for activated glycoprotein (GP) IIb/IIIa. |
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In Vitro |
Glycoprotein (GP) IIb/IIIa, which exists on the membrane of platelets, changes its form from inactive to active when platelets adhere to collagen exposed on sites of vascular injury. In the circulation, platelet aggregation is mediated by fibrinogen by bridging adjacent platelets through GPIIb/IIIa in an activation-dependent manner. A dodecapeptide HHLGGAKQAGDV (H12), corresponding to the fibrinogen γ-chain carboxy-terminal sequence (γ400-411), is a specific binding site of the ligand for activated GPIIb/IIIa MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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Molecular Weight |
1189.28 |
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Formula |
C50H80N18O16 |
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CAS No. |
89105-94-2 |
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Appearance |
Solid |
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Color |
White to off-white |
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Sequence |
His-His-Leu-Gly-Gly-Ala-Lys-Gln-Ala-Gly-Asp-Val |
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Sequence Shortening |
HHLGGAKQAGDV |
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Shipping | Room temperature in continental US; may vary elsewhere. |
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Storage |
Sealed storage, away from moisture
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
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Solvent & Solubility |
In Vitro:
H2O : 100 mg/mL (84.08 mM; Need ultrasonic) DMSO : 100 mg/mL (84.08 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles. * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration:
mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
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Purity & Documentation | |||||||||||||
References |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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H2O / DMSO | 1 mM | 0.8408 mL | 4.2042 mL | 8.4084 mL | 21.0211 mL |
5 mM | 0.1682 mL | 0.8408 mL | 1.6817 mL | 4.2042 mL | |
10 mM | 0.0841 mL | 0.4204 mL | 0.8408 mL | 2.1021 mL | |
15 mM | 0.0561 mL | 0.2803 mL | 0.5606 mL | 1.4014 mL | |
20 mM | 0.0420 mL | 0.2102 mL | 0.4204 mL | 1.0511 mL | |
25 mM | 0.0336 mL | 0.1682 mL | 0.3363 mL | 0.8408 mL | |
30 mM | 0.0280 mL | 0.1401 mL | 0.2803 mL | 0.7007 mL | |
40 mM | 0.0210 mL | 0.1051 mL | 0.2102 mL | 0.5255 mL | |
50 mM | 0.0168 mL | 0.0841 mL | 0.1682 mL | 0.4204 mL | |
60 mM | 0.0140 mL | 0.0701 mL | 0.1401 mL | 0.3504 mL | |
80 mM | 0.0105 mL | 0.0526 mL | 0.1051 mL | 0.2628 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Fibrinogen Binding Inhibitor Peptide Related Classifications
- Cardiovascular Disease