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Colchicine [64-86-8]

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Cat# HY-16569-500mg

Size : 500mg

Brand : MedChemExpress

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Colchicine, an orally active alkaloid, is a potent tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC50 of 3 nM. Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs). Colchicine prevents non-steroidal anti-inflammatory drug (NSAID)-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome. Colchicine has extensive anti-inflammatory, immunosuppressive and strong anti-fibrosis effects and has the potential for gouty arthritis research.

For research use only. We do not sell to patients.

Colchicine Chemical Structure

Colchicine Chemical Structure

CAS No. : 64-86-8

This product is a controlled substance and not for sale in your territory.

Based on 35 publication(s) in Google Scholar

Other Forms of Colchicine:

  • Colchicine-d6 Get quote
  • Colchicine-d3 Get quote
  • Colchicine (Standard) Get quote

    Colchicine purchased from MedChemExpress. Usage Cited in: Oxid Med Cell Longev. 2020 Jul 15;2020:9173530.  [Abstract]

    Colchicine plays an antipyroptosis role by inhibiting intracellular oxidative stress. HUVECs are treated for 10 or 24 h with different doses of Colchicine (0-10 nM) in the presence of cholesterol crystal (0.5 mg/mL). Intracellular ROS level is detected using a DCFH-DA probe. JC-1 Staining Kit is used for the detection of mitochondrial membrane potential.

    Colchicine purchased from MedChemExpress. Usage Cited in: Oxid Med Cell Longev. 2020 Jul 15;2020:9173530.  [Abstract]

    Colchicine alleviates NLRP3 inflammasome activation relevant in pyroptosis. HUVECs are treated for 24 h with different doses of Colchicine (0-10 nM) in the presence of cholesterol crystal (0.5 mg/mL. Western blotting Is dedicated to examine the protein expression levels of NLRP3, ASC-1, procaspase-1, caspase-1, IL-18, and IL-1β. Colchicine treatment significantly blocks NLRP3 signal activity. Colchicine significantly inhibits CC-induced mRNA and protein expression of IL-18 and IL-1β, particularl

    Colchicine purchased from MedChemExpress. Usage Cited in: Biochim Biophys Acta. 2018 May;1862(5):1134-1147.  [Abstract]

    CS1 and Colchicine (Col) induce the phosphorylation of H1 (T18) and H3 (S29) as detected by western blotting.

    View All NOD-like Receptor (NLR) Isoform Specific Products:

    View All Isoforms
    NLRP3 NLRP1 NOD1 NOD2
    Description

    Colchicine, an orally active alkaloid, is a potent tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC50 of 3 nM. Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs). Colchicine prevents non-steroidal anti-inflammatory drug (NSAID)-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome. Colchicine has extensive anti-inflammatory, immunosuppressive and strong anti-fibrosis effects and has the potential for gouty arthritis research[1][2][3][4][5].

    IC50 & Target

    Microtubule/Tubulin[1]
    Cellular Effect
    Cell Line Type Value Description References
    5637 EC50
    0.053 μM
    Compound: Colchicine
    Antiproliferative activity against human 5637 cells after 96 hrs by MTT assay
    Antiproliferative activity against human 5637 cells after 96 hrs by MTT assay
    		[PMID: 29055869]
    786-0 IC50
    0.022 μM
    Compound: Colchicine
    Cytotoxicity against human 786-O cells after 72 hrs by MTT assay
    Cytotoxicity against human 786-O cells after 72 hrs by MTT assay
    		[PMID: 30106297]
    786-0 IC50
    26.8 nM
    Compound: Colchicine
    Antiproliferative activity against human 786-O cells incubated for 72 hrs by MTT assay
    Antiproliferative activity against human 786-O cells incubated for 72 hrs by MTT assay
    		[PMID: 34648295]
    A10 EC50
    0.03 μM
    Compound: 1
    Inhibition of microtubule depolymerization in rat A10 cells after 18 hrs by immunofluorescence assay
    Inhibition of microtubule depolymerization in rat A10 cells after 18 hrs by immunofluorescence assay
    		[PMID: 23457660]
    A10 EC50
    0.03 μM
    Compound: 1
    Induction of interphase microtubule depolymerization in rat A10 cells after 18 to 24 hrs by DAPI staining-based indirect immunofluorescence assay
    Induction of interphase microtubule depolymerization in rat A10 cells after 18 to 24 hrs by DAPI staining-based indirect immunofluorescence assay
    		[PMID: 23961916]
    A2780 IC50
    > 20 μM
    Compound: Colchicine
    Cytotoxicity against taxol-resistant human A2780 cells by MTT assay
    Cytotoxicity against taxol-resistant human A2780 cells by MTT assay
    		[PMID: 23425970]
    A2780 IC50
    0.008 μM
    Compound: Colchicine
    Antiproliferative activity against human A2780 cells assessed as reduction in cell viability after 48 hrs by MTT assay
    Antiproliferative activity against human A2780 cells assessed as reduction in cell viability after 48 hrs by MTT assay
    		[PMID: 31185410]
    A2780 IC50
    0.015 μM
    Compound: colchicine
    Cytotoxicity against human A2780 cells after 24 hrs by MTT assay
    Cytotoxicity against human A2780 cells after 24 hrs by MTT assay
    		[PMID: 25426924]
    A2780 IC50
    0.02 μM
    Compound: Colchicine
    Cytotoxicity against human A2780S cells by MTT assay
    Cytotoxicity against human A2780S cells by MTT assay
    		[PMID: 23425970]
    A2780 IC50
    0.057 μM
    Compound: COL
    Antiproliferative activity against human A2780 cells after 48 hrs by SRB method
    Antiproliferative activity against human A2780 cells after 48 hrs by SRB method
    		[PMID: 25061803]
    A2780 IC50
    0.59 μM
    Compound: COL
    Antiproliferative activity against taxol-resistant human A2780 cells after 48 hrs by SRB method
    Antiproliferative activity against taxol-resistant human A2780 cells after 48 hrs by SRB method
    		[PMID: 25061803]
    A2780 IC50
    13.1 nM
    Compound: 4; COL
    Cytotoxicity against human A2780 cells after 48 hrs by MTT assay
    Cytotoxicity against human A2780 cells after 48 hrs by MTT assay
    		[PMID: 30448418]
    A2780 IC50
    14 nM
    Compound: Colchicine
    Antiproliferative activity against human A2780 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
    Antiproliferative activity against human A2780 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
    		[PMID: 33618157]
    A2780 IC50
    4 nM
    Compound: colchicine
    Antiproliferative activity against human A2780S cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay
    Antiproliferative activity against human A2780S cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay
    		[PMID: 25208345]
    A2780 EC50
    8.7 nM
    Compound: Colchicine
    Antiproliferative activity against D4-9-31 resistance human A2780 cells incubated for 72 hrs by ATPlite reagent based assay
    Antiproliferative activity against D4-9-31 resistance human A2780 cells incubated for 72 hrs by ATPlite reagent based assay
    		[PMID: 31047749]
    A2780 EC50
    9.2 nM
    Compound: Colchicine
    Antiproliferative activity against human A2780 cells incubated for 72 hrs by ATPlite reagent based assay
    Antiproliferative activity against human A2780 cells incubated for 72 hrs by ATPlite reagent based assay
    		[PMID: 31047749]
    A2780 ADR IC50
    0.306 μM
    Compound: colchicine
    Cytotoxicity against human A2780AD cells after 24 hrs by MTT assay
    Cytotoxicity against human A2780AD cells after 24 hrs by MTT assay
    		[PMID: 25426924]
    A2780 ADR IC50
    16.8 nM
    Compound: colchicine
    Cytotoxicity against human A2780AD cells expressing p-gp after 96 hrs by MTT assay
    Cytotoxicity against human A2780AD cells expressing p-gp after 96 hrs by MTT assay
    		[PMID: 23176628]
    A2780/Taxol IC50
    35632.33 nM
    Compound: Colchicine
    Antiproliferative activity against human A2780T cells after 48 to 72 hrs by MTT assay
    Antiproliferative activity against human A2780T cells after 48 to 72 hrs by MTT assay
    		[PMID: 29754076]
    A2780/Taxol IC50
    783.8 nM
    Compound: Colchicine
    Antiproliferative activity against human A2780T cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
    Antiproliferative activity against human A2780T cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
    		[PMID: 33788562]
    A2780/Taxol IC50
    8671 nM
    Compound: 1
    Cytotoxicity against beta-tubulin 3 overexpressing human A2780T cells assessed as reduction in cell growth after 24 hrs by MTT assay
    Cytotoxicity against beta-tubulin 3 overexpressing human A2780T cells assessed as reduction in cell growth after 24 hrs by MTT assay
    		[PMID: 27213819]
    A2780S IC50
    12.3 nM
    Compound: Colchicine
    Antiproliferative activity against human A2780S cells after 48 hrs by MTT assay
    Antiproliferative activity against human A2780S cells after 48 hrs by MTT assay
    		[PMID: 28763646]
    A2780S IC50
    16.7 nM
    Compound: Colchicine
    Antiproliferative activity against human A2780S cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
    Antiproliferative activity against human A2780S cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
    		[PMID: 33788562]
    A2780S IC50
    21.86 nM
    Compound: Colchicine
    Antiproliferative activity against human A2780S cells after 48 to 72 hrs by MTT assay
    Antiproliferative activity against human A2780S cells after 48 to 72 hrs by MTT assay
    		[PMID: 29754076]
    A2780S IC50
    30.8 nM
    Compound: 1
    Antiproliferative activity against human A2780S cells after 24 hrs by MTT assay
    Antiproliferative activity against human A2780S cells after 24 hrs by MTT assay
    		[PMID: 27213819]
    A2780S IC50
    31 nM
    Compound: Colchicine
    Antiproliferative activity against human A2780S cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
    Antiproliferative activity against human A2780S cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
    		[PMID: 35084853]
    A2780S IC50
    34.1 nM
    Compound: Colchicine
    Antiproliferative activity against human A2780S cells incubated for 72 hrs by MTT assay
    Antiproliferative activity against human A2780S cells incubated for 72 hrs by MTT assay
    		[PMID: 34648295]
    A-375 IC50
    0.01 μM
    Compound: Colchicine
    Antiproliferative activity against human A375 cells assessed as cell growth inhibition after 96 hrs by MTT assay
    Antiproliferative activity against human A375 cells assessed as cell growth inhibition after 96 hrs by MTT assay
    		[PMID: 27094151]
    A-375 IC50
    0.02 μM
    Compound: Colchicine
    Antiproliferative activity against human A375 cells after 48 hrs by SRB assay
    Antiproliferative activity against human A375 cells after 48 hrs by SRB assay
    		[PMID: 22608389]
    A-375 IC50
    0.02 μM
    Compound: colchicine
    Cytotoxicity against human A375 cells after 48 hrs by SRB assay
    Cytotoxicity against human A375 cells after 48 hrs by SRB assay
    		[PMID: 19243174]
    A-375 IC50
    0.02 μM
    Compound: Colchicine
    Antiproliferative activity against human A375 cells after 48 hrs by sulforhodamine B assay
    Antiproliferative activity against human A375 cells after 48 hrs by sulforhodamine B assay
    		[PMID: 21775150]
    A-375 IC50
    10.9 nM
    Compound: Colchicine
    Antiproliferative activity against human A-375 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTS assay
    Antiproliferative activity against human A-375 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTS assay
    		[PMID: 34406768]
    A-375 IC50
    12 nM
    Compound: colchicine
    Antiproliferative activity against human A375 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay
    Antiproliferative activity against human A375 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay
    		[PMID: 25208345]
    A-375 IC50
    14.1 nM
    Compound: Colchicine
    Antiproliferative activity against human A375 cells after 72 hrs by MTT assay
    Antiproliferative activity against human A375 cells after 72 hrs by MTT assay
    		[PMID: 31251599]
    A-375 IC50
    16.8 nM
    Compound: Colchicine
    Cytotoxicity against human A-375 cells measured after 72 hrs by western blot
    Cytotoxicity against human A-375 cells measured after 72 hrs by western blot
    		[PMID: 34378386]
    A-375 IC50
    20 nM
    Compound: Colchicine
    Cytotoxicity against human A375 cells after 48 hrs by sulforhodamine B assay
    Cytotoxicity against human A375 cells after 48 hrs by sulforhodamine B assay
    		[PMID: 20919720]
    A-375 IC50
    20.6 nM
    Compound: Colchicine
    Antiproliferative activity against human A375 cells after 48 hrs by SRB assay
    Antiproliferative activity against human A375 cells after 48 hrs by SRB assay
    		[PMID: 22783954]
    A-375 IC50
    6.4 nM
    Compound: Colchicine
    Cytotoxicity against human A375 cells after 72 hrs by MTS assay
    Cytotoxicity against human A375 cells after 72 hrs by MTS assay
    		[PMID: 29406710]
    A-375 IC50
    9.7 nM
    Compound: Colchicine
    Antiproliferative activity against human A375 cells after 72 hrs by MTS assay
    Antiproliferative activity against human A375 cells after 72 hrs by MTS assay
    		[PMID: 30099258]
    A375/TxR IC50
    23.6 nM
    Compound: Colchicine
    Antiproliferative activity against human A375/TxR cells assessed as inhibition of cell proliferation measured after 72 hrs by MTS assay
    Antiproliferative activity against human A375/TxR cells assessed as inhibition of cell proliferation measured after 72 hrs by MTS assay
    		[PMID: 34406768]
    A375/TxR IC50
    29.6 nM
    Compound: Colchicine
    Cytotoxicity against paclitaxel resistant human A-375/TxR cells measured after 72 hrs by western blot
    Cytotoxicity against paclitaxel resistant human A-375/TxR cells measured after 72 hrs by western blot
    		[PMID: 34378386]
    A-427 EC50
    0.045 μM
    Compound: Colchicine
    Antiproliferative activity against human A427 cells after 96 hrs by MTT assay
    Antiproliferative activity against human A427 cells after 96 hrs by MTT assay
    		[PMID: 29055869]
    A-431 EC50
    0.0028 μM
    Compound: Colchicine
    Cell cycle arrest in A431 cells by accumulation at G2/M phase cell
    Cell cycle arrest in A431 cells by accumulation at G2/M phase cell
    		[PMID: 16198562]
    A-431 IC50
    0.008 μM
    Compound: Colchicine
    Cytotoxicity against human A431 cells assessed as growth inhibition after 72 hrs by CCK-8 assay
    Cytotoxicity against human A431 cells assessed as growth inhibition after 72 hrs by CCK-8 assay
    		[PMID: 25091926]
    A-431 IC50
    0.019 μM
    Compound: Colchicine
    Cytotoxicity against human A431 cells after 72 hrs by MTT assay
    Cytotoxicity against human A431 cells after 72 hrs by MTT assay
    		[PMID: 23602523]
    A-431 IC50
    53.2 nM
    Compound: Colchicine
    Antiproliferative activity against human A431 cells after 72 hrs by sulforhodamine B assay
    Antiproliferative activity against human A431 cells after 72 hrs by sulforhodamine B assay
    		[PMID: 21480626]
    A549 IC50
    < 1 μM
    Compound: Colchicine
    Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
    Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
    		[PMID: 20833451]
    A549 ED50
    0.002 μg/mL
    Compound: colchicine
    Cytotoxicity against human lung carcinoma cells (A-549) using SRB assay.
    Cytotoxicity against human lung carcinoma cells (A-549) using SRB assay.
    		[PMID: 9544215]
    A549 IC50
    0.013 μM
    Compound: Colchicine
    Antiproliferative activity against human A549 cells harboring control siRNA after 48 hrs by MTT assay
    Antiproliferative activity against human A549 cells harboring control siRNA after 48 hrs by MTT assay
    		[PMID: 31185410]
    A549 IC50
    0.015 μM
    Compound: Colchicine
    Antiproliferative activity against human A549 cells harboring katanin siRNA after 48 hrs by MTT assay
    Antiproliferative activity against human A549 cells harboring katanin siRNA after 48 hrs by MTT assay
    		[PMID: 31185410]
    A549 IC50
    0.017 μM
    Compound: Colchicine
    Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay
    Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay
    		[PMID: 31185410]
    A549 ED50
    0.0199 μg/mL
    Compound: 1
    Cytotoxicity against human A549 cells after 2 days
    Cytotoxicity against human A549 cells after 2 days
    		[PMID: 20542428]
    A549 IC50
    0.02 μM
    Compound: Colchicine
    Antiproliferative activity against human A549 cells by SRB assay
    Antiproliferative activity against human A549 cells by SRB assay
    		[PMID: 28988750]
    A549 IC50
    0.023 μM
    Compound: Colchicine
    Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
    Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
    		[PMID: 30093295]
    A549 IC50
    0.023 μM
    Compound: Colchicine
    Cytotoxicity against human A549 cells after 72 hrs by MTT assay
    Cytotoxicity against human A549 cells after 72 hrs by MTT assay
    		[PMID: 23602523]
    A549 IC50
    0.024 μM
    Compound: Col
    Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
    Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
    		[PMID: 34311158]
    A549 IC50
    0.03 μM
    Compound: Colchicine
    Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
    Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
    		[PMID: 36511661]
    A549 GI50
    0.03 μM
    Compound: Colchicine
    Antiproliferative activity against human A549 cells after 48 hrs by SRB assay
    Antiproliferative activity against human A549 cells after 48 hrs by SRB assay
    		[PMID: 25827522]
    A549 IC50
    0.031 μM
    Compound: Colchicine
    Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
    Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
    		[PMID: 35447432]
    A549 IC50
    0.042 μM
    Compound: 1
    Cytotoxicity against human A549 cells incubated for 48 hrs by MTT assay
    Cytotoxicity against human A549 cells incubated for 48 hrs by MTT assay
    		[PMID: 32432867]
    A549 IC50
    0.043 μM
    Compound: Colchicine
    Cytotoxicity against human A549 cells after 72 hrs by MTT assay
    Cytotoxicity against human A549 cells after 72 hrs by MTT assay
    		[PMID: 30106297]
    A549 IC50
    0.045 μM
    Compound: 1, colchicine
    Antiproliferative activity against human A549 cells after 72 hrs
    Antiproliferative activity against human A549 cells after 72 hrs
    		[PMID: 18503262]
    A549 IC50
    0.05 μM
    Compound: COL
    Antiproliferative activity against human A549 cells after 48 hrs by SRB method
    Antiproliferative activity against human A549 cells after 48 hrs by SRB method
    		[PMID: 25061803]
    A549 IC50
    0.053 μM
    Compound: Colchicine
    Cytotoxicity against human A549 cells assessed as reduction in cell growth by CCK8 assay
    Cytotoxicity against human A549 cells assessed as reduction in cell growth by CCK8 assay
    		[PMID: 33753264]
    A549 IC50
    0.054 μM
    Compound: 1
    Antiproliferative activity against human A549 cells incubated for 72 hrs by sulforhodamine B assay
    Antiproliferative activity against human A549 cells incubated for 72 hrs by sulforhodamine B assay
    		[PMID: 32432867]
    A549 IC50
    0.054 μM
    Compound: 1
    Cytotoxicity against human A549 cells after 96 hrs using tetracolor one
    Cytotoxicity against human A549 cells after 96 hrs using tetracolor one
    		[PMID: 24900316]
    A549 IC50
    0.081 μM
    Compound: COL
    Antiproliferative activity against cis-platinum-resistant human A549 cells after 48 hrs by SRB method
    Antiproliferative activity against cis-platinum-resistant human A549 cells after 48 hrs by SRB method
    		[PMID: 25061803]
    A549 IC50
    0.095 μM
    Compound: Colchicine
    Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
    Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
    		[PMID: 34571171]
    A549 IC50
    0.105 μM
    Compound: Colchicine
    Cytotoxicity against human A549 cells assessed as growth inhibition after 72 hrs by MTT assay
    Cytotoxicity against human A549 cells assessed as growth inhibition after 72 hrs by MTT assay
    		[PMID: 25805446]
    A549 IC50
    0.107 μM
    Compound: Colchicine
    Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK-8 assay
    Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK-8 assay
    		[PMID: 32650183]
    A549 IC50
    0.108 μM
    Compound: Colchicine
    Antiproliferative activity against human A549 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
    Antiproliferative activity against human A549 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
    		[PMID: 33788562]
    A549 IC50
    0.111 μM
    Compound: Colchicine
    Antiproliferative activity against human A549 assessed as reduction in cell viability measured after 48 hrs by MTT assay
    Antiproliferative activity against human A549 assessed as reduction in cell viability measured after 48 hrs by MTT assay
    		[PMID: 34175541]
    A549 IC50
    0.12 μg/mL
    Compound: Colchicine
    Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
    Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
    		[PMID: 21440448]
    A549 IC50
    0.12 μM
    Compound: Colchicine
    Cytotoxicity against human A549 cells after 48 hrs by MTT assay
    Cytotoxicity against human A549 cells after 48 hrs by MTT assay
    		[PMID: 25499929]
    A549 IC50
    0.137 μM
    Compound: 1
    Antiproliferative activity against human A549 cells after 72 hrs by MTT assay
    Antiproliferative activity against human A549 cells after 72 hrs by MTT assay
    		[PMID: 30245397]
    A549 IC50
    0.184 μM
    Compound: Colchicine
    Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
    Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
    		[PMID: 36455508]
    A549 IC50
    0.19 μM
    Compound: Colchicine
    Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK8 assay
    Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK8 assay
    		[PMID: 34022412]
    A549 IC50
    0.19 μM
    Compound: Colchicine
    Antiproliferative activity against human A549 cells incubated for 48 hrs by CCK8 assay
    Antiproliferative activity against human A549 cells incubated for 48 hrs by CCK8 assay
    		[PMID: 33965530]
    A549 IC50
    0.2 μg/mL
    Compound: Colchicine
    Cytotoxicity against human A549 cells after 48 hrs by MTT assay
    Cytotoxicity against human A549 cells after 48 hrs by MTT assay
    		[PMID: 22578453]
    A549 IC50
    0.22 μM
    Compound: Colchicine
    Antiproliferative activity against human A549 cells after 24 hrs by MTT assay
    Antiproliferative activity against human A549 cells after 24 hrs by MTT assay
    		[PMID: 30606674]
    A549 IC50
    0.47 μM
    Compound: Colchicine
    Antiproliferative activity against human A549 cells measured after 24 hrs by MTT assay
    Antiproliferative activity against human A549 cells measured after 24 hrs by MTT assay
    		10.1039/C6MD00255B
    A549 IC50
    0.47 μM
    Compound: Colchicine
    Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 24 hrs in presence of foetal bovine serum by MTT assay
    Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 24 hrs in presence of foetal bovine serum by MTT assay
    		[PMID: 35367708]
    A549 IC50
    0.58 μg/mL
    Compound: 1
    Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
    Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
    		[PMID: 24916028]
    A549 IC50
    0.58 μM
    Compound: Colchicine
    Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
    Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
    		[PMID: 25703297]
    A549 IC50
    0.74 μg/mL
    Compound: Colchicine
    Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
    Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
    		[PMID: 22503741]
    A549 IC50
    0.75 μg/mL
    Compound: Colchicine
    Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
    Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
    		[PMID: 22261027]
    A549 IC50
    0.75 μM
    Compound: Colchicine
    Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
    Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
    		[PMID: 22512906]
    A549 IC50
    0.89 μM
    Compound: Col
    Cytotoxicity against human A549 cells assessed as inhibition of cell growth measured for 24 hrs by MTT assay
    Cytotoxicity against human A549 cells assessed as inhibition of cell growth measured for 24 hrs by MTT assay
    		[PMID: 36970147]
    A549 IC50
    1.09 μM
    Compound: Colchicine
    Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
    Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
    		[PMID: 37122544]
    A549 IC50
    1.17 μM
    Compound: Colchicine
    Antiproliferative activity against human A549 cells incubated for 48 hrs by MTT assay
    Antiproliferative activity against human A549 cells incubated for 48 hrs by MTT assay
    		[PMID: 32035399]
    A549 IC50
    10.78 ng/mL
    Compound: colchicine
    Cytotoxicity against human A549 cells after 24 hrs by YO-PRO-1 assay
    Cytotoxicity against human A549 cells after 24 hrs by YO-PRO-1 assay
    		[PMID: 19138858]
    A549 IC50
    10.78 ng/mL
    Compound: colchicine
    Cytotoxicity against human A549 cells after 24 hrs by propidium iodide assay
    Cytotoxicity against human A549 cells after 24 hrs by propidium iodide assay
    		[PMID: 19138858]
    A549 IC50
    12.2 nM
    Compound: Colchicine
    Antiproliferative activity against human A549 cells after 2 days by MTT assay
    Antiproliferative activity against human A549 cells after 2 days by MTT assay
    		[PMID: 29550732]
    A549 IC50
    125 nM
    Compound: 1
    Antiproliferative activity against human A549 cells incubated for 72 hrs by SRB assay
    Antiproliferative activity against human A549 cells incubated for 72 hrs by SRB assay
    		[PMID: 33465696]
    A549 IC50
    125.2 nM
    Compound: 1
    Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 120 hrs by MTT assay
    Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 120 hrs by MTT assay
    		[PMID: 31653441]
    A549 IC50
    14 nM
    Compound: Colchicine
    Cytotoxicity against human A549 cells assessed as growth inhibition after 72 hrs by MTT assay
    Cytotoxicity against human A549 cells assessed as growth inhibition after 72 hrs by MTT assay
    		[PMID: 27915168]
    A549 IC50
    19.3 nM
    Compound: COLCH
    Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation incubated for 72 hrs by SRB assay
    Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation incubated for 72 hrs by SRB assay
    		[PMID: 34592435]
    A549 IC50
    20 nM
    Compound: 3
    Cytotoxicity against human A549 cells after 72 hrs by CCK-8 assay
    Cytotoxicity against human A549 cells after 72 hrs by CCK-8 assay
    		[PMID: 23360369]
    A549 IC50
    20 nM
    Compound: 1
    Cytotoxicity against human A549 cells assessed as growth inhibition after 48 hrs by MTT assay
    Cytotoxicity against human A549 cells assessed as growth inhibition after 48 hrs by MTT assay
    		[PMID: 23214452]
    A549 IC50
    21 nM
    Compound: 1; (-)-Colchicine
    Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 24 hrs by SRB assay
    Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 24 hrs by SRB assay
    		[PMID: 31655432]
    A549 IC50
    23.9 nM
    Compound: 1
    Cytotoxicity against human A549 cells after 48 hrs by Celltiter-Glo luminescent cell viability assay
    Cytotoxicity against human A549 cells after 48 hrs by Celltiter-Glo luminescent cell viability assay
    		[PMID: 26985296]
    A549 EC50
    27 nM
    Compound: Colchicine
    Cytotoxicity against human A549 cells after 24 hrs by MTT assay
    Cytotoxicity against human A549 cells after 24 hrs by MTT assay
    		[PMID: 21873068]
    A549 IC50
    32.7 nM
    Compound: Colchicine
    Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
    Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
    		[PMID: 28763646]
    A549 IC50
    32.76 nM
    Compound: Colchicine
    Antiproliferative activity against human A549 cells after 48 to 72 hrs by MTT assay
    Antiproliferative activity against human A549 cells after 48 to 72 hrs by MTT assay
    		[PMID: 29754076]
    A549 IC50
    37 nM
    Compound: Colchicine
    Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
    Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
    		[PMID: 33234343]
    A549 IC50
    37 nM
    Compound: Colchicine
    Antiproliferative activity against human A549 cells after 72 hrs by sulforhodamine B assay
    Antiproliferative activity against human A549 cells after 72 hrs by sulforhodamine B assay
    		[PMID: 21480626]
    A549 GI50
    4.4 μM
    Compound: Colchicine
    Growth inhibition of human A549 cells assessed as inhibition of cell proliferation after 24 hrs by MTT assay
    Growth inhibition of human A549 cells assessed as inhibition of cell proliferation after 24 hrs by MTT assay
    		[PMID: 26070164]
    A549 IC50
    4.64 μM
    Compound: Colchicine
    Antiproliferative activity against human A549 cells after 24 hrs by MTT assay
    Antiproliferative activity against human A549 cells after 24 hrs by MTT assay
    		[PMID: 29268130]
    A549 IC50
    400 nM
    Compound: 1
    Cytotoxicity against 2D culture of human A549 cells measured after 72 hrs by MTT assay
    Cytotoxicity against 2D culture of human A549 cells measured after 72 hrs by MTT assay
    		[PMID: 27912174]
    A549 IC50
    45.2 nM
    Compound: 1
    Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 72 hrs by SRB assay
    Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 72 hrs by SRB assay
    		[PMID: 33611191]
    A549 IC50
    5.13 μM
    Compound: COL
    Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
    Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
    		[PMID: 35694693]
    A549 IC50
    50.6 nM
    Compound: 1
    Cytotoxicity against human A549 cells after 48 hrs by WST-8 assay
    Cytotoxicity against human A549 cells after 48 hrs by WST-8 assay
    		[PMID: 22727370]
    A549 IC50
    54.4 nM
    Compound: 1
    Cytotoxicity against human A549 cells assessed as inhibition of cell proliferation after 96 hrs
    Cytotoxicity against human A549 cells assessed as inhibition of cell proliferation after 96 hrs
    		10.1039/C3MD00287J
    A549 IC50
    54.4 nM
    Compound: 1
    Cytotoxicity against human A549 cells after 96 hrs by microplate reader analysis
    Cytotoxicity against human A549 cells after 96 hrs by microplate reader analysis
    		10.1039/C2MD20250F
    A549 IC50
    59.06 μM
    Compound: 1
    Growth inhibition of human A549 cells incubated for 48 hrs by MTT assay
    Growth inhibition of human A549 cells incubated for 48 hrs by MTT assay
    		[PMID: 27172319]
    A549 IC50
    62.7 nM
    Compound: Colchicine
    Antiproliferative activity against human A549 cells after 72 hrs by MTS assay
    Antiproliferative activity against human A549 cells after 72 hrs by MTS assay
    		[PMID: 30099258]
    A549 IC50
    76 nM
    Compound: 1
    Antiproliferative activity against human A549 cells assessed as inhibition of proliferation after 72 hrs by SRB assay
    Antiproliferative activity against human A549 cells assessed as inhibition of proliferation after 72 hrs by SRB assay
    		[PMID: 34116158]
    A549 IC50
    77.6 nM
    Compound: Colchicine
    Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTS assay
    Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTS assay
    		[PMID: 34406768]
    A549 IC50
    9.7 μM
    Compound: Colchicine
    Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay
    Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay
    		[PMID: 30878833]
    A549/TR IC50
    167.34 nM
    Compound: Colchicine
    Antiproliferative activity against human A549/TR cells after 48 to 72 hrs by MTT assay
    Antiproliferative activity against human A549/TR cells after 48 to 72 hrs by MTT assay
    		[PMID: 29754076]
    A549/TR IC50
    202.9 nM
    Compound: Colchicine
    Antiproliferative activity against human A549/Taxol cells assessed as inhibition of cell proliferation measured after 72 hrs by MTS assay
    Antiproliferative activity against human A549/Taxol cells assessed as inhibition of cell proliferation measured after 72 hrs by MTS assay
    		[PMID: 34406768]
    ACHN IC50
    39.8 nM
    Compound: colchicine
    Antiproliferative activity against drug resistant ACHN cell line expressing MDR1 by Alamar Blue assay
    Antiproliferative activity against drug resistant ACHN cell line expressing MDR1 by Alamar Blue assay
    		[PMID: 17286393]
    AGS GI50
    0.04 μM
    Compound: Colchicine
    Antiproliferative activity against human AGS cells after 48 hrs by MTT assay
    Antiproliferative activity against human AGS cells after 48 hrs by MTT assay
    		[PMID: 28763647]
    AGS IC50
    9 nM
    Compound: colchicine
    Antiproliferative activity against human AGS cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay
    Antiproliferative activity against human AGS cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay
    		[PMID: 25208345]
    B16 IC50
    0.031 μM
    Compound: Colchicine
    Cytotoxicity against mouse B16 cells assessed as cell viability after 48 hrs by MTT test
    Cytotoxicity against mouse B16 cells assessed as cell viability after 48 hrs by MTT test
    		[PMID: 18583138]
    B16-F0 IC50
    0.087 μM
    Compound: Colchicine
    Antiproliferative activity against mouse B16-F0 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK-8 assay
    Antiproliferative activity against mouse B16-F0 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK-8 assay
    		[PMID: 32650183]
    B16-F1 IC50
    0.029 μM
    Compound: colchicine
    Cytotoxicity against mouse B16-F1 cells after 48 hrs by SRB assay
    Cytotoxicity against mouse B16-F1 cells after 48 hrs by SRB assay
    		[PMID: 19243174]
    B16-F1 IC50
    29 nM
    Compound: Colchicine
    Cytotoxicity against mouse B16-F1 cells after 48 hrs by sulforhodamine B assay
    Cytotoxicity against mouse B16-F1 cells after 48 hrs by sulforhodamine B assay
    		[PMID: 20919720]
    B16-F10 IC50
    0.003 μM
    Compound: Colchicine
    Antiproliferative activity against mouse B16-F10 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
    Antiproliferative activity against mouse B16-F10 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
    		[PMID: 36511661]
    B16-F10 IC50
    0.029 μM
    Compound: 1, colchicine
    Antiproliferative activity against mouse B16F10 cells after 72 hrs
    Antiproliferative activity against mouse B16F10 cells after 72 hrs
    		[PMID: 18503262]
    B16-F10 IC50
    0.083 μM
    Compound: Colchicine
    Antiproliferative activity against mouse B16-F10 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
    Antiproliferative activity against mouse B16-F10 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
    		[PMID: 33788562]
    B16-F10 IC50
    0.48 μg/mL
    Compound: 1
    Antiproliferative activity against mouse B16F10 cells after 48 hrs by MTT assay
    Antiproliferative activity against mouse B16F10 cells after 48 hrs by MTT assay
    		[PMID: 24916028]
    B16-F10 IC50
    0.48 μM
    Compound: Colchicine
    Antiproliferative activity against mouse B16F10 cells after 48 hrs by MTT assay
    Antiproliferative activity against mouse B16F10 cells after 48 hrs by MTT assay
    		[PMID: 25703297]
    B16-F10 IC50
    0.5 μg/mL
    Compound: Colchicine
    Antiproliferative activity against mouse B16F10 cells after 48 hrs by MTT assay
    Antiproliferative activity against mouse B16F10 cells after 48 hrs by MTT assay
    		[PMID: 21440448]
    B16-F10 IC50
    0.5 μg/mL
    Compound: 1
    Antiproliferative activity against mouse B16F10 cells after 48 hrs by MTT based ELISA assay
    Antiproliferative activity against mouse B16F10 cells after 48 hrs by MTT based ELISA assay
    		[PMID: 21783370]
    B16-F10 IC50
    0.8 μg/mL
    Compound: Colchicine
    Cytotoxicity against mouse B16F10 cells after 48 hrs by MTT assay
    Cytotoxicity against mouse B16F10 cells after 48 hrs by MTT assay
    		[PMID: 22578453]
    B16-F10 IC50
    32 nM
    Compound: Colchicine
    Antiproliferative activity against mouse B16F10 cells after 72 hrs by MTS assay
    Antiproliferative activity against mouse B16F10 cells after 72 hrs by MTS assay
    		[PMID: 30099258]
    B16-F10 IC50
    32.84 μM
    Compound: Col
    Cytotoxicity against mouse B16-F10 cells assessed as inhibition of cell growth measured for 24 hrs by MTT assay
    Cytotoxicity against mouse B16-F10 cells assessed as inhibition of cell growth measured for 24 hrs by MTT assay
    		[PMID: 36970147]
    B16-F10 IC50
    44.25 nM
    Compound: Colchicine
    Antiproliferative activity against mouse B16F10 cells after 72 hrs by MTT assay
    Antiproliferative activity against mouse B16F10 cells after 72 hrs by MTT assay
    		[PMID: 30197030]
    B16-F10 IC50
    9.6 μM
    Compound: Colchicine
    Induction of cell cycle arrest in mouse B16-F10 cells assessed as accumulation of cells at G2/M phase incubated for 48 hrs by RNase/PI staining based flow cytometry analysis
    Induction of cell cycle arrest in mouse B16-F10 cells assessed as accumulation of cells at G2/M phase incubated for 48 hrs by RNase/PI staining based flow cytometry analysis
    		[PMID: 35043615]
    BALB/3T3 IC50
    0.054 μM
    Compound: 1
    Cytotoxicity against mouse BALB/3T3 cells incubated for 72 hrs by sulforhodamine B assay
    Cytotoxicity against mouse BALB/3T3 cells incubated for 72 hrs by sulforhodamine B assay
    		[PMID: 32432867]
    BALB/3T3 IC50
    100 nM
    Compound: 1
    Antiproliferative activity against mouse BALB/3T3 cells assessed as inhibition of proliferation after 72 hrs by SRB assay
    Antiproliferative activity against mouse BALB/3T3 cells assessed as inhibition of proliferation after 72 hrs by SRB assay
    		[PMID: 34116158]
    BALB/3T3 IC50
    106 nM
    Compound: 1
    Antiproliferative activity against mouse BALB/3T3 cells incubated for 72 hrs by SRB assay
    Antiproliferative activity against mouse BALB/3T3 cells incubated for 72 hrs by SRB assay
    		[PMID: 33465696]
    BALB/3T3 IC50
    139.4 nM
    Compound: 1
    Antiproliferative activity against mouse BALB/3T3 cells assessed as reduction in cell viability incubated for 120 hrs by MTT assay
    Antiproliferative activity against mouse BALB/3T3 cells assessed as reduction in cell viability incubated for 120 hrs by MTT assay
    		[PMID: 31653441]
    BALB/3T3 IC50
    33.1 nM
    Compound: 1
    Cytotoxicity against mouse BALB/3T3 cells assessed as inhibition of cell growth measured after 72 hrs by SRB assay
    Cytotoxicity against mouse BALB/3T3 cells assessed as inhibition of cell growth measured after 72 hrs by SRB assay
    		[PMID: 33611191]
    BALB/3T3 IC50
    82.3 nM
    Compound: COLCH
    Cytotoxicity against mouse BALB/3T3 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay
    Cytotoxicity against mouse BALB/3T3 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay
    		[PMID: 34592435]
    BEAS-2B IC50
    0.016 μM
    Compound: Colchicine
    Cytotoxicity against human BEAS-2B cells assessed as reduction in cell growth by CCK8 assay
    Cytotoxicity against human BEAS-2B cells assessed as reduction in cell growth by CCK8 assay
    		[PMID: 33753264]
    Bel-7402 IC50
    0.04 μM
    Compound: Colchicine
    Antiproliferative activity against human Bel7402 cells after 72 hrs by sulforhodamine B assay
    Antiproliferative activity against human Bel7402 cells after 72 hrs by sulforhodamine B assay
    		[PMID: 21480626]
    Bel-7402 IC50
    0.3 μg/mL
    Compound: colchicine
    Cytotoxicity against human Bel7402 cells after 48 hrs by MTT assay
    Cytotoxicity against human Bel7402 cells after 48 hrs by MTT assay
    		[PMID: 15620246]
    Bel-7402 IC50
    0.4 μg/mL
    Compound: Colchicine
    Cytotoxicity against human Bel7402 cells after 48 hrs by MTT assay
    Cytotoxicity against human Bel7402 cells after 48 hrs by MTT assay
    		[PMID: 15165134]
    Bel-7402 IC50
    1.31 μM
    Compound: Colchicine
    Cytotoxicity against human Bel7402 cells by MTT assay
    Cytotoxicity against human Bel7402 cells by MTT assay
    		[PMID: 23425970]
    BGC-823 IC50
    0.016 μM
    Compound: Colchicine
    Antiproliferative activity against human BGC-823 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
    Antiproliferative activity against human BGC-823 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
    		[PMID: 36511661]
    BGC-823 IC50
    0.6 μg/mL
    Compound: colchicine
    Cytotoxicity against human BGC823 cells after 48 hrs by MTT assay
    Cytotoxicity against human BGC823 cells after 48 hrs by MTT assay
    		[PMID: 15620246]
    BJAB IC50
    0.02 μM
    Compound: 1
    Antiproliferative activity against human BJAB cells after 24 hrs by CASY cell counting method
    Antiproliferative activity against human BJAB cells after 24 hrs by CASY cell counting method
    		10.1039/C5MD00320B
    BT-474 IC50
    12.46 μM
    Compound: Col
    Cytotoxicity against human BT-474 cells assessed as inhibition of cell growth measured for 24 hrs by MTT assay
    Cytotoxicity against human BT-474 cells assessed as inhibition of cell growth measured for 24 hrs by MTT assay
    		[PMID: 36970147]
    BT-474 IC50
    3.8 nM
    Compound: 1
    Cytotoxicity against human BT474 cells assessed as cell viability after 4 days by MTS assay
    Cytotoxicity against human BT474 cells assessed as cell viability after 4 days by MTS assay
    		[PMID: 24210503]
    BT-549 IC50
    0.023 μM
    Compound: colchicine
    Antiproliferative activity against human BT549 cells after 48 hrs by alamar blue assay
    Antiproliferative activity against human BT549 cells after 48 hrs by alamar blue assay
    		[PMID: 21563750]
    Burkitts lymphoma cell IC50
    0.05 μM
    Compound: 1
    Growth inhibition on human burkitt lymphoma cells after 36 h
    Growth inhibition on human burkitt lymphoma cells after 36 h
    		[PMID: 8496935]
    BXPC-3 IC50
    0.016 μM
    Compound: 1
    Cell cycle arrest in human BxPC3 cells assessed as accumulation at G2/M phase after 24 hrs using propidium iodide staining by FACS analysis
    Cell cycle arrest in human BxPC3 cells assessed as accumulation at G2/M phase after 24 hrs using propidium iodide staining by FACS analysis
    		[PMID: 21126027]
    BXPC-3 IC50
    0.042 μM
    Compound: 1
    Cytotoxicity against human BxPC-3 cells incubated for 48 hrs by MTT assay
    Cytotoxicity against human BxPC-3 cells incubated for 48 hrs by MTT assay
    		[PMID: 32432867]
    BXPC-3 IC50
    16 nM
    Compound: 1
    Cytotoxicity against human BxPC-3 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
    Cytotoxicity against human BxPC-3 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
    		[PMID: 33479669]
    BXPC-3 IC50
    80 nM
    Compound: 1
    Cytotoxicity against 2D culture of human BxPC3 cells measured after 72 hrs by MTT assay
    Cytotoxicity against 2D culture of human BxPC3 cells measured after 72 hrs by MTT assay
    		[PMID: 27912174]
    C6 EC50
    1 x 10-1 μM
    Compound: Colchicine
    Inhibition of tubulin polymerization in rat C6 cells after 4 hrs
    Inhibition of tubulin polymerization in rat C6 cells after 4 hrs
    		[PMID: 8988604]
    Caco-2 GI50
    0.03 μM
    Compound: Colchicine
    Antiproliferative activity against human Caco2 cells assessed as growth inhibition after 72 hrs by sulforhodamine B assay
    Antiproliferative activity against human Caco2 cells assessed as growth inhibition after 72 hrs by sulforhodamine B assay
    		[PMID: 30288225]
    CAL-27 IC50
    37.5 nM
    Compound: Colchicine
    Antiproliferative activity against human CAL-27 cells assessed as cell growth inhibition incubated for 72 hrs by CCK-8 assay
    Antiproliferative activity against human CAL-27 cells assessed as cell growth inhibition incubated for 72 hrs by CCK-8 assay
    		[PMID: 35576703]
    CCRF-CEM IC50
    0.013 μM
    Compound: 1, colch
    Antiproliferative activity against human CEM cells after 48 to 96 hrs by coulter counter analysis
    Antiproliferative activity against human CEM cells after 48 to 96 hrs by coulter counter analysis
    		[PMID: 24773591]
    CCRF-CEM IC50
    0.013 μM
    Compound: 5
    Antiproliferative activity against human CEM cells measured after 96 hrs by Coulter counter method
    Antiproliferative activity against human CEM cells measured after 96 hrs by Coulter counter method
    		[PMID: 30921759]
    CCRF-CEM IC50
    0.013 μM
    Compound: Colchicine
    Antiproliferative activity against human CEM cells after 96 hrs by coulter counting method
    Antiproliferative activity against human CEM cells after 96 hrs by coulter counting method
    		[PMID: 29471122]
    CCRF-CEM IC50
    0.0172 μM
    Compound: Colchicine
    Cytotoxicity against human CEM cells after 72 hrs by MTT assay
    Cytotoxicity against human CEM cells after 72 hrs by MTT assay
    		[PMID: 21536450]
    CCRF-CEM EC50
    0.021 μM
    Compound: Colchicine
    Antiproliferative activity against human CCRF-CEM cells after 96 hrs by MTT assay
    Antiproliferative activity against human CCRF-CEM cells after 96 hrs by MTT assay
    		[PMID: 29055869]
    CCRF-CEM IC50
    0.031 μM
    Compound: Colchicine
    Antiproliferative activity against human CEM cells assessed as inhibition of cell proliferation after 96 hrs by Coulter counter based cell counting method
    Antiproliferative activity against human CEM cells assessed as inhibition of cell proliferation after 96 hrs by Coulter counter based cell counting method
    		[PMID: 25282265]
    CCRF-CEM IC50
    7.9 nM
    Compound: Col
    Antiproliferative activity against human CEM after 48 hrs by SRB assay
    Antiproliferative activity against human CEM after 48 hrs by SRB assay
    		[PMID: 21920638]
    CCRF-CEM IC50
    7.9 nM
    Compound: Col
    Antiproliferative activity against human CEM cells after 48 hrs by sulforhodamine B assay
    Antiproliferative activity against human CEM cells after 48 hrs by sulforhodamine B assay
    		[PMID: 21604746]
    CEM-VLB IC50
    360 nM
    Compound: Col
    Antiproliferative activity against human multidrug-resistant CEM/VLB cells after 48 hrs by SRB assay
    Antiproliferative activity against human multidrug-resistant CEM/VLB cells after 48 hrs by SRB assay
    		[PMID: 21920638]
    CEM-VLB IC50
    360 nM
    Compound: Col
    Antiproliferative activity against multidrug-resistant human CEM/VLB cells after 48 hrs by sulforhodamine B assay
    Antiproliferative activity against multidrug-resistant human CEM/VLB cells after 48 hrs by sulforhodamine B assay
    		[PMID: 21604746]
    CHL-1 IC50
    3.6 nM
    Compound: Colchicine
    Antiproliferative activity against human CHL-1 cells after 72 hrs by MTS assay
    Antiproliferative activity against human CHL-1 cells after 72 hrs by MTS assay
    		[PMID: 30099258]
    CHO IC50
    220 nM
    Compound: Col
    Antiproliferative activity against human CHO after 48 hrs by SRB assay
    Antiproliferative activity against human CHO after 48 hrs by SRB assay
    		[PMID: 21920638]
    CHO IC50
    220 nM
    Compound: Col
    Antiproliferative activity against CHO cells after 48 hrs by sulforhodamine B assay
    Antiproliferative activity against CHO cells after 48 hrs by sulforhodamine B assay
    		[PMID: 21604746]
    CHO-TAX 5-6 IC50
    140 nM
    Compound: Col
    Antiproliferative activity against paclitaxel-resistant CHO-TAX 5-6 cells after 48 hrs by SRB assay
    Antiproliferative activity against paclitaxel-resistant CHO-TAX 5-6 cells after 48 hrs by SRB assay
    		[PMID: 21920638]
    CHO-TAX 5-6 IC50
    140 nM
    Compound: Col
    Antiproliferative activity against paclitaxel-resistant CHO-TAX 5-6 cells after 48 hrs by sulforhodamine B assay
    Antiproliferative activity against paclitaxel-resistant CHO-TAX 5-6 cells after 48 hrs by sulforhodamine B assay
    		[PMID: 21604746]
    CHO-VV 3-2 IC50
    620 nM
    Compound: Col
    Antiproliferative activity against colchicine and vinblastine-resistant CHO-VV 3-2 cells after 48 hrs by SRB assay
    Antiproliferative activity against colchicine and vinblastine-resistant CHO-VV 3-2 cells after 48 hrs by SRB assay
    		[PMID: 21920638]
    CHO-VV 3-2 IC50
    620 nM
    Compound: Col
    Antiproliferative activity against paclitaxel-resistant CHO-VV 3-2 cells after 48 hrs by sulforhodamine B assay
    Antiproliferative activity against paclitaxel-resistant CHO-VV 3-2 cells after 48 hrs by sulforhodamine B assay
    		[PMID: 21604746]
    CNE-2 IC50
    0.034 μM
    Compound: COL
    Antiproliferative activity against human CNE2 cells after 48 hrs by SRB method
    Antiproliferative activity against human CNE2 cells after 48 hrs by SRB method
    		[PMID: 25061803]
    COLO 205 IC50
    0.003 μM
    Compound: Colchicine
    Cytotoxicity against human COLO205 cells assessed as growth inhibition by MTT assay
    Cytotoxicity against human COLO205 cells assessed as growth inhibition by MTT assay
    		[PMID: 25091926]
    COLO 205 IC50
    0.021 μM
    Compound: colchicine
    Antiproliferative activity against human COLO205 cells after 48 hrs by alamar blue assay
    Antiproliferative activity against human COLO205 cells after 48 hrs by alamar blue assay
    		[PMID: 21563750]
    COLO 205 IC50
    0.032 μM
    Compound: 1; (-)-Colchicine
    Antiproliferative activity against human COLO205 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
    Antiproliferative activity against human COLO205 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
    		[PMID: 31655432]
    COLO357 IC50
    1.3 nM
    Compound: 1
    Antiproliferative activity against human COLO357 cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay
    Antiproliferative activity against human COLO357 cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay
    		[PMID: 32827941]
    COLO357 IC50
    1.3 nM
    Compound: 1
    Cytotoxic activity in human Colo-357 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
    Cytotoxic activity in human Colo-357 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
    		[PMID: 29028531]
    COLO357 IC50
    16 nM
    Compound: 1
    Cytotoxicity against human COLO-357 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
    Cytotoxicity against human COLO-357 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
    		[PMID: 33479669]
    COLO357 IC50
    160 nM
    Compound: 1
    Cytotoxicity against 2D culture of human Colo-357 cells measured after 72 hrs by MTT assay
    Cytotoxicity against 2D culture of human Colo-357 cells measured after 72 hrs by MTT assay
    		[PMID: 27912174]
    DAN-G EC50
    0.059 μM
    Compound: Colchicine
    Antiproliferative activity against human DAN-G cells after 96 hrs by MTT assay
    Antiproliferative activity against human DAN-G cells after 96 hrs by MTT assay
    		[PMID: 29055869]
    DLD-1 IC50
    0.089 μM
    Compound: colchicine
    Antiproliferative activity against human DLD1 cells after 48 hrs by alamar blue assay
    Antiproliferative activity against human DLD1 cells after 48 hrs by alamar blue assay
    		[PMID: 21563750]
    DLD-1 EC50
    0.18 μM
    Compound: Colchicine
    Induction of apoptosis in human DLD1 cells assessed as caspase activation after 48 hrs
    Induction of apoptosis in human DLD1 cells assessed as caspase activation after 48 hrs
    		[PMID: 19500976]
    DLD-1 EC50
    0.19 μM
    Compound: colchicine
    Induction of apoptosis in human DLD1 cells assessed as caspase activation after 24 hrs
    Induction of apoptosis in human DLD1 cells assessed as caspase activation after 24 hrs
    		[PMID: 15566300]
    DLD-1 IC50
    11 nM
    Compound: colchicine
    Antiproliferative activity against human DLD1 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay
    Antiproliferative activity against human DLD1 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay
    		[PMID: 25208345]
    DLD-1 IC50
    15.6 nM
    Compound: colchicine
    Cytotoxicity against human DLD1 cells after 96 hrs by MTT assay
    Cytotoxicity against human DLD1 cells after 96 hrs by MTT assay
    		[PMID: 23176628]
    DLD-1 IC50
    43 nM
    Compound: 1
    Cytotoxicity against human DLD1 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay
    Cytotoxicity against human DLD1 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay
    		[PMID: 30429975]
    DU-145 ED50
    0.0027 μg/mL
    Compound: 1
    Cytotoxicity against human DU145 cells after 2 days
    Cytotoxicity against human DU145 cells after 2 days
    		[PMID: 20542428]
    DU-145 IC50
    0.003 μM
    Compound: Colchicine
    Antiproliferative activity against human DU-145 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
    Antiproliferative activity against human DU-145 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
    		[PMID: 36511661]
    DU-145 IC50
    0.01 μM
    Compound: colchicine
    Cytotoxicity against human DU145 cells after 48 hrs by SRB assay
    Cytotoxicity against human DU145 cells after 48 hrs by SRB assay
    		[PMID: 19243174]
    DU-145 IC50
    0.01 μM
    Compound: Colchicine
    Antiproliferative activity against human DU145 cells after 96 hrs by sulforhodamine B assay
    Antiproliferative activity against human DU145 cells after 96 hrs by sulforhodamine B assay
    		[PMID: 21775150]
    DU-145 EC50
    0.018 μM
    Compound: Colchicine
    Antiproliferative activity against human DU145 cells after 96 hrs by MTT assay
    Antiproliferative activity against human DU145 cells after 96 hrs by MTT assay
    		[PMID: 29055869]
    DU-145 IC50
    0.3 μM
    Compound: Colchicine
    Cytotoxicity against human DU145 cells by MTT assay
    Cytotoxicity against human DU145 cells by MTT assay
    		[PMID: 23425970]
    DU-145 IC50
    0.69 μM
    Compound: Colchicine
    Cytotoxicity against human DU145 cells after 48 hrs by MTT assay
    Cytotoxicity against human DU145 cells after 48 hrs by MTT assay
    		[PMID: 25499929]
    DU-145 IC50
    10 nM
    Compound: Col
    Antiproliferative activity against human DU145 after 48 hrs by SRB assay
    Antiproliferative activity against human DU145 after 48 hrs by SRB assay
    		[PMID: 21920638]
    DU-145 IC50
    10 nM
    Compound: Col
    Antiproliferative activity against human DU145 cells after 48 hrs by sulforhodamine B assay
    Antiproliferative activity against human DU145 cells after 48 hrs by sulforhodamine B assay
    		[PMID: 21604746]
    DU-145 IC50
    10 nM
    Compound: Colchicine
    Cytotoxicity against human DU145 cells after 48 hrs by sulforhodamine B assay
    Cytotoxicity against human DU145 cells after 48 hrs by sulforhodamine B assay
    		[PMID: 20919720]
    DU-145 IC50
    11.2 nM
    Compound: Colchicine
    Antiproliferative activity against human DU145 cells after 48 hrs by SRB assay
    Antiproliferative activity against human DU145 cells after 48 hrs by SRB assay
    		[PMID: 22783954]
    DU-145 IC50
    17.3 nM
    Compound: Colchicine
    Antiproliferative activity against human DU145 cells measured after 72 hrs by MTS assay
    Antiproliferative activity against human DU145 cells measured after 72 hrs by MTS assay
    		[PMID: 31860298]
    DU-145 IC50
    25.7 nM
    Compound: Colchicine
    Cytotoxicity against human DU145 cells after 72 hrs by MTS assay
    Cytotoxicity against human DU145 cells after 72 hrs by MTS assay
    		[PMID: 29406710]
    DU-145 IC50
    3.45 nM
    Compound: Colchicine
    Antiproliferative activity against human DU145 cells after 72 hrs by MTT assay
    Antiproliferative activity against human DU145 cells after 72 hrs by MTT assay
    		[PMID: 30197030]
    EA.hy 926 IC50
    > 800 nM
    Compound: 1
    Cytotoxicity against 2D culture of human EAhy926 cells measured after 72 hrs by MTT assay
    Cytotoxicity against 2D culture of human EAhy926 cells measured after 72 hrs by MTT assay
    		[PMID: 27912174]
    ECa-109 cell line IC50
    1.24 μM
    Compound: Colchicine
    Antiproliferative activity against human EC109 cells after 48 hrs by MTT assay
    Antiproliferative activity against human EC109 cells after 48 hrs by MTT assay
    		[PMID: 30075402]
    Epithelial cell IC50
    9.26 μM
    Compound: Colchicine
    Antiproliferative activity against human mammary epithelial cells after 48 hrs by MTT assay
    Antiproliferative activity against human mammary epithelial cells after 48 hrs by MTT assay
    		[PMID: 27608432]
    FaDu IC50
    22.8 nM
    Compound: Colchicine
    Antiproliferative activity against human FaDu cells assessed as cell growth inhibition incubated for 72 hrs by CCK-8 assay
    Antiproliferative activity against human FaDu cells assessed as cell growth inhibition incubated for 72 hrs by CCK-8 assay
    		[PMID: 35576703]
    H9 IC50
    0.018 μM
    Compound: 1
    Antiviral activity against HIV1 HTLV-3B in human H9 cells after 3 days by p24 antigen capture assay
    Antiviral activity against HIV1 HTLV-3B in human H9 cells after 3 days by p24 antigen capture assay
    		[PMID: 1919593]
    HaCaT IC50
    0.3 nM
    Compound: 1
    Cytotoxicity against human HaCat cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay
    Cytotoxicity against human HaCat cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay
    		[PMID: 32827941]
    HaCaT IC50
    12 nM
    Compound: Colchicine
    Antiproliferative activity against human HaCaT cells assessed as cell viability by MTT assay
    Antiproliferative activity against human HaCaT cells assessed as cell viability by MTT assay
    		[PMID: 23063401]
    HaCaT IC50
    3 nM
    Compound: 1
    Cytotoxicity against human HaCaT cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
    Cytotoxicity against human HaCaT cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
    		[PMID: 33479669]
    HaCaT IC50
    80 nM
    Compound: 1
    Cytotoxicity against 2D culture of human HaCaT cells measured after 72 hrs by MTT assay
    Cytotoxicity against 2D culture of human HaCaT cells measured after 72 hrs by MTT assay
    		[PMID: 27912174]
    HCT-116 IC50
    0.003 μM
    Compound: Colchicine
    Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
    Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
    		[PMID: 36511661]
    HCT-116 IC50
    0.005 μM
    Compound: Colchicine
    Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability after 48 hrs by MTT assay
    Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability after 48 hrs by MTT assay
    		[PMID: 31185410]
    HCT-116 IC50
    0.01 μM
    Compound: Colchicine
    Antiproliferative activity against human HCT116 cells by SRB assay
    Antiproliferative activity against human HCT116 cells by SRB assay
    		[PMID: 28988750]
    HCT-116 IC50
    0.011 μM
    Compound: Colchicine
    Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
    Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
    		[PMID: 36455508]
    HCT-116 IC50
    0.011 μM
    Compound: 1
    Cytotoxicity against human HCT116 cells after 96 hrs using tetracolor one
    Cytotoxicity against human HCT116 cells after 96 hrs using tetracolor one
    		[PMID: 24900316]
    HCT-116 EC50
    0.015 μM
    Compound: colchicine
    Induction of apoptosis in human HCT116 cells assessed as caspase activation after 24 hrs by HTS assay
    Induction of apoptosis in human HCT116 cells assessed as caspase activation after 24 hrs by HTS assay
    		[PMID: 18197614]
    HCT-116 EC50
    0.015 μM
    Compound: colchicine
    Induction of apoptosis in human HCT116 cells assessed as caspase 3 activation after 24 hrs
    Induction of apoptosis in human HCT116 cells assessed as caspase 3 activation after 24 hrs
    		[PMID: 18651728]
    HCT-116 IC50
    0.037 μM
    Compound: Colchicine
    Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay
    Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay
    		[PMID: 23602523]
    HCT-116 IC50
    0.039 μM
    Compound: Colchicine
    Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay
    Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay
    		[PMID: 30093295]
    HCT-116 IC50
    0.04 μM
    Compound: Colchicine
    Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by MTT assay
    Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by MTT assay
    		[PMID: 25805446]
    HCT-116 IC50
    0.04 μM
    Compound: Colchicine
    Cytotoxicity against human HCT116 cells assessed as reduction in cell viability after 72 hrs by SRB assay
    Cytotoxicity against human HCT116 cells assessed as reduction in cell viability after 72 hrs by SRB assay
    		[PMID: 30883116]
    HCT-116 IC50
    0.04 μM
    Compound: 1, colchicine
    Antiproliferative activity against human HCT116 cells after 72 hrs
    Antiproliferative activity against human HCT116 cells after 72 hrs
    		[PMID: 18503262]
    HCT-116 IC50
    0.042 μM
    Compound: Colchicine
    Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK-8 assay
    Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK-8 assay
    		[PMID: 32650183]
    HCT-116 IC50
    0.046 μM
    Compound: Colchicine
    Antiproliferative activity against human HCT-116 cells after 48 hrs by MTT assay
    Antiproliferative activity against human HCT-116 cells after 48 hrs by MTT assay
    		[PMID: 34968813]
    HCT-116 IC50
    0.05 μM
    Compound: 1; (-)-Colchicine
    Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
    Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
    		[PMID: 31655432]
    HCT-116 IC50
    0.08 μM
    Compound: Colchicine
    Cytotoxicity in human HCT-116 cells assessed as growth inhibition level after 48 hrs by SRB assay
    Cytotoxicity in human HCT-116 cells assessed as growth inhibition level after 48 hrs by SRB assay
    		[PMID: 36162138]
    HCT-116 IC50
    0.081 μM
    Compound: Colchicine
    Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
    Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
    		[PMID: 35834904]
    HCT-116 IC50
    0.083 μM
    Compound: Colchicine
    Antiproliferative activity against human HCT-116 assessed as reduction in cell viability measured after 48 hrs by MTT assay
    Antiproliferative activity against human HCT-116 assessed as reduction in cell viability measured after 48 hrs by MTT assay
    		[PMID: 34175541]
    HCT-116 IC50
    0.108 μM
    Compound: Colchicine
    Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
    Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
    		[PMID: 35605363]
    HCT-116 IC50
    0.129 μM
    Compound: Colchicine
    Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
    Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
    		[PMID: 32682200]
    HCT-116 IC50
    0.13 μM
    Compound: Colchicine
    Antiproliferative activity against human HCT-116 cells assessed as cell growth inhibition measured after 48 hrs by CCK8 assay
    Antiproliferative activity against human HCT-116 cells assessed as cell growth inhibition measured after 48 hrs by CCK8 assay
    		[PMID: 34971875]
    HCT-116 IC50
    0.55 μM
    Compound: Col
    Cytotoxicity against human HCT-116 cells assessed as inhibition of cell growth measured for 24 hrs by MTT assay
    Cytotoxicity against human HCT-116 cells assessed as inhibition of cell growth measured for 24 hrs by MTT assay
    		[PMID: 36970147]
    HCT-116 GI50
    1.2 μM
    Compound: Colchicine
    Antiproliferative activity against human HCT116 cells assessed as growth inhibition after 72 hrs by sulforhodamine B assay
    Antiproliferative activity against human HCT116 cells assessed as growth inhibition after 72 hrs by sulforhodamine B assay
    		[PMID: 30288225]
    HCT-116 IC50
    1.85 μM
    Compound: Colchicine
    Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
    Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
    		[PMID: 37122544]
    HCT-116 IC50
    10.6 nM
    Compound: 1
    Cytotoxicity against human HCT116 cells assessed as inhibition of cell proliferation after 96 hrs
    Cytotoxicity against human HCT116 cells assessed as inhibition of cell proliferation after 96 hrs
    		10.1039/C3MD00287J
    HCT-116 IC50
    10.6 nM
    Compound: 1
    Cytotoxicity against human HCT116 cells after 96 hrs by microplate reader analysis
    Cytotoxicity against human HCT116 cells after 96 hrs by microplate reader analysis
    		10.1039/C2MD20250F
    HCT-116 IC50
    13.9 nM
    Compound: Colchicine
    Antiproliferative activity against human HCT116 cells after 72 hrs by MTS assay
    Antiproliferative activity against human HCT116 cells after 72 hrs by MTS assay
    		[PMID: 30099258]
    HCT-116 IC50
    13.9 nM
    Compound: Colchicine
    Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay
    Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay
    		[PMID: 28763646]
    HCT-116 IC50
    15 nM
    Compound: colchicine
    Antiproliferative activity against human HCT116 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay
    Antiproliferative activity against human HCT116 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay
    		[PMID: 25208345]
    HCT-116 IC50
    2.13 μM
    Compound: Colchicine
    Antiproliferative activity against human HCT116 cells incubated for 48 hrs by MTT assay
    Antiproliferative activity against human HCT116 cells incubated for 48 hrs by MTT assay
    		[PMID: 32035399]
    HCT-116 IC50
    20 nM
    Compound: 1
    Cytotoxicity against human HCT116 assessed as growth inhibition after 72 hrs by Celltiter-Glo luminescent assay
    Cytotoxicity against human HCT116 assessed as growth inhibition after 72 hrs by Celltiter-Glo luminescent assay
    		[PMID: 23214452]
    HCT-116 IC50
    26.18 nM
    Compound: Colchicine
    Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay
    Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay
    		[PMID: 30197030]
    HCT-116 IC50
    27.5 nM
    Compound: Colchicine
    Antiproliferative activity against human HCT116 cells incubated for 72 hrs by MTT assay
    Antiproliferative activity against human HCT116 cells incubated for 72 hrs by MTT assay
    		[PMID: 34648295]
    HCT-116 IC50
    27.8 nM
    Compound: 1
    Antiproliferative activity against human HCT116 cells after 24 hrs by MTT assay
    Antiproliferative activity against human HCT116 cells after 24 hrs by MTT assay
    		[PMID: 27213819]
    HCT-116 IC50
    32 nM
    Compound: colchicine
    Cytotoxicity against human HCT116 cells after 72 hrs
    Cytotoxicity against human HCT116 cells after 72 hrs
    		[PMID: 19530698]
    HCT-116 IC50
    5.13 μM
    Compound: Colchicine
    Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell proliferation measured after 48 hrs by MTT assay
    Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell proliferation measured after 48 hrs by MTT assay
    		[PMID: 32768647]
    HCT-15 IC50
    0.08 μM
    Compound: Colchicine
    Cytotoxicity against human HCT15 cells by MTT assay
    Cytotoxicity against human HCT15 cells by MTT assay
    		[PMID: 23425970]
    HCT-15 IC50
    100 nM
    Compound: colchicine
    Antiproliferative activity against drug resistant HCT15 cell line expressing MDR1 by Alamar Blue assay
    Antiproliferative activity against drug resistant HCT15 cell line expressing MDR1 by Alamar Blue assay
    		[PMID: 17286393]
    HCT-15 IC50
    16 nM
    Compound: colchicine
    Antiproliferative activity against human HCT15 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay
    Antiproliferative activity against human HCT15 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay
    		[PMID: 25208345]
    HCT-15 IC50
    86 nM
    Compound: 1
    Cytotoxicity against human HCT15 cells assessed as growth inhibition after 72 hrs by Celltiter-Glo luminescent assay
    Cytotoxicity against human HCT15 cells assessed as growth inhibition after 72 hrs by Celltiter-Glo luminescent assay
    		[PMID: 23214452]
    HCT-15 IC50
    9 nM
    Compound: 1; (-)-Colchicine
    Antiproliferative activity against human HCT15 cells assessed as reduction in cell viability incubated for 24 hrs by SRB assay
    Antiproliferative activity against human HCT15 cells assessed as reduction in cell viability incubated for 24 hrs by SRB assay
    		[PMID: 31655432]
    HCT-8 ED50
    0.016 μg/mL
    Compound: colchicine
    Cytotoxicity against human ileocecal carcinoma cells (HCT-8) using SRB assay.
    Cytotoxicity against human ileocecal carcinoma cells (HCT-8) using SRB assay.
    		[PMID: 9544215]
    HCT-8 IC50
    0.022 μM
    Compound: Colchicine
    Antiproliferative activity against human HCT-8 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
    Antiproliferative activity against human HCT-8 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
    		[PMID: 36511661]
    HCT-8 ED50
    0.054 μg/mL
    Compound: 1
    Cytotoxicity against human HCT8 cells after 2 days
    Cytotoxicity against human HCT8 cells after 2 days
    		[PMID: 20542428]
    HCT-8 IC50
    0.059 μM
    Compound: COL
    Antiproliferative activity against human HCT8 cells after 48 hrs by SRB method
    Antiproliferative activity against human HCT8 cells after 48 hrs by SRB method
    		[PMID: 25061803]
    HCT-8 IC50
    1.1 μM
    Compound: COL
    Antiproliferative activity against vincristine-resistant human HCT8 cells after 48 hrs by SRB method
    Antiproliferative activity against vincristine-resistant human HCT8 cells after 48 hrs by SRB method
    		[PMID: 25061803]
    HCT-8 IC50
    11.8 μM
    Compound: Colchicine
    Cytotoxicity against taxol-resistant human HCT8 cells by MTT assay
    Cytotoxicity against taxol-resistant human HCT8 cells by MTT assay
    		[PMID: 23425970]
    HCT-8 IC50
    13.4 nM
    Compound: Colchicine
    Antiproliferative activity against human HCT8 cells after 48 hrs by MTT assay
    Antiproliferative activity against human HCT8 cells after 48 hrs by MTT assay
    		[PMID: 28763646]
    HCT-8 IC50
    2433 nM
    Compound: 1
    Cytotoxicity against vinblastine resistant/P-gp overexpressing human HCT8 cells assessed as reduction in cell growth after 24 hrs by MTT assay
    Cytotoxicity against vinblastine resistant/P-gp overexpressing human HCT8 cells assessed as reduction in cell growth after 24 hrs by MTT assay
    		[PMID: 27213819]
    HCT-8 IC50
    29.7 nM
    Compound: 1
    Antiproliferative activity against human HCT8 cells after 24 hrs by MTT assay
    Antiproliferative activity against human HCT8 cells after 24 hrs by MTT assay
    		[PMID: 27213819]
    HEK293 IC50
    > 25 μM
    Compound: COL
    Cytotoxicity against human HEK293 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
    Cytotoxicity against human HEK293 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
    		[PMID: 35694693]
    HEK293 IC50
    0.005 μM
    Compound: colchicine
    Cytotoxicity against human HEK293 cells after 3 days by MTT assay
    Cytotoxicity against human HEK293 cells after 3 days by MTT assay
    		[PMID: 25426924]
    HEK293 IC50
    0.009 μM
    Compound: Colchicine
    Cytotoxicity against human HEK293 cells after 72 hrs by MTT assay
    Cytotoxicity against human HEK293 cells after 72 hrs by MTT assay
    		[PMID: 23932339]
    HEK293 IC50
    0.02 μM
    Compound: 2
    Cytotoxicity against HEK293 cells after 68 hrs by MTT assay
    Cytotoxicity against HEK293 cells after 68 hrs by MTT assay
    		[PMID: 32243160]
    HEK293 EC50
    0.03 μM
    Compound: Colchicine
    Cytotoxicity against HEK293 cells after 48 hrs by MTS assay
    Cytotoxicity against HEK293 cells after 48 hrs by MTS assay
    		[PMID: 24842619]
    HEK293 IC50
    0.042 μM
    Compound: 1
    Cytotoxicity against HEK293 cells incubated for 48 hrs by MTT assay
    Cytotoxicity against HEK293 cells incubated for 48 hrs by MTT assay
    		[PMID: 32432867]
    HEK293 IC50
    10.2 nM
    Compound: Colchicine
    Antiproliferative activity against HEK293 cells after 48 hrs by MTT assay
    Antiproliferative activity against HEK293 cells after 48 hrs by MTT assay
    		[PMID: 28763646]
    HEK293 IC50
    13 nM
    Compound: Colchicine
    Antiproliferative activity against human HEK293 cells after 2 days by MTT assay
    Antiproliferative activity against human HEK293 cells after 2 days by MTT assay
    		[PMID: 29604583]
    HEK293 IC50
    16 nM
    Compound: 1
    Cytotoxicity against human HEK293 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
    Cytotoxicity against human HEK293 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
    		[PMID: 33479669]
    HEK293 IC50
    16 nM
    Compound: 1
    Cytotoxicity against human HEK293 cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay
    Cytotoxicity against human HEK293 cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay
    		[PMID: 32827941]
    HEK293 IC50
    32 nM
    Compound: 1
    Cytotoxic activity in HEK293 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
    Cytotoxic activity in HEK293 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
    		[PMID: 29028531]
    HEK293 IC50
    5 nM
    Compound: Colchicine
    Antiproliferative activity against HEK293 cells after 2 days by MTT assay
    Antiproliferative activity against HEK293 cells after 2 days by MTT assay
    		[PMID: 29550732]
    HEK293 IC50
    5 nM
    Compound: Colchicine
    Cytotoxicity against HEK293 cells assessed as growth inhibition after 72 hrs by MTT assay
    Cytotoxicity against HEK293 cells assessed as growth inhibition after 72 hrs by MTT assay
    		[PMID: 27915168]
    HEK-293T IC50
    1.03 μM
    Compound: Colchicine
    Cytotoxicity against human HEK293T cells assessed as inhibition of cell growth incubated for 24 hrs in presence of foetal bovine serum by MTT assay
    Cytotoxicity against human HEK293T cells assessed as inhibition of cell growth incubated for 24 hrs in presence of foetal bovine serum by MTT assay
    		[PMID: 35367708]
    HEK-293T CC50
    129.32 μM
    Compound: Colchicine
    Cytotoxicity against HEK293T cells after 24 hrs by MTT assay
    Cytotoxicity against HEK293T cells after 24 hrs by MTT assay
    		[PMID: 30606674]
    HEK-293T CC50
    152 μM
    Compound: Colchicine
    Antiproliferative activity against human 293T cells measured after 24 hrs by MTT assay
    Antiproliferative activity against human 293T cells measured after 24 hrs by MTT assay
    		10.1039/C6MD00255B
    HEK-293T IC50
    3.86 μM
    Compound: Col
    Cytotoxicity against human HEK293T cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay
    Cytotoxicity against human HEK293T cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay
    		[PMID: 36760739]
    HEK-293T IC50
    6.38 μM
    Compound: Colchicine
    Antiproliferative activity against human 293T cells after 24 hrs by MTT assay
    Antiproliferative activity against human 293T cells after 24 hrs by MTT assay
    		[PMID: 29268130]
    HEK-293T CC50
    8.43 μM
    Compound: Colchicine
    Antiproliferative activity against human HEK293T cells incubated for 48 hrs by MTT assay
    Antiproliferative activity against human HEK293T cells incubated for 48 hrs by MTT assay
    		[PMID: 32035399]
    HEK-293T IC50
    801.2 μM
    Compound: Colchicine
    Cytotoxicity against human HEK293T cells expressing ABCB1 (unknown origin) measured after 72 hrs by MTT assay
    Cytotoxicity against human HEK293T cells expressing ABCB1 (unknown origin) measured after 72 hrs by MTT assay
    		[PMID: 34546748]
    HeLa IC50
    < 1 μM
    Compound: Colchicine
    Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
    Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
    		[PMID: 20833451]
    HeLa IC50
    0.003 μM
    Compound: 1
    Cytotoxicity in human HeLa cells assessed as reduction in cell viability after 4 days under dark condition by MTT assay
    Cytotoxicity in human HeLa cells assessed as reduction in cell viability after 4 days under dark condition by MTT assay
    		[PMID: 29172077]
    HeLa IC50
    0.006 μM
    Compound: Colchicine
    Cytotoxicity in human HeLa cells assessed as growth inhibition level after 48 hrs by SRB assay
    Cytotoxicity in human HeLa cells assessed as growth inhibition level after 48 hrs by SRB assay
    		[PMID: 36162138]
    HeLa IC50
    0.0076 μM
    Compound: 1
    Growth inhibition of human HeLa cells incubated for 72 hrs by MTT assay
    Growth inhibition of human HeLa cells incubated for 72 hrs by MTT assay
    		[PMID: 27172319]
    HeLa IC50
    0.008 μM
    Compound: Colchicine
    Cytotoxicity against human HeLa cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
    Cytotoxicity against human HeLa cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
    		[PMID: 35447432]
    HeLa IC50
    0.0087 μM
    Compound: 5
    Antiproliferative activity against human HeLa cells measured after 3 days by Coulter counter method
    Antiproliferative activity against human HeLa cells measured after 3 days by Coulter counter method
    		[PMID: 30921759]
    HeLa IC50
    0.0087 μM
    Compound: Colchicine
    Antiproliferative activity against human HeLa cells after 3 days by coulter counting method
    Antiproliferative activity against human HeLa cells after 3 days by coulter counting method
    		[PMID: 29471122]
    HeLa IC50
    0.0087 μM
    Compound: 1, colch
    Antiproliferative activity against human HeLa cells after 4 days by coulter counter analysis
    Antiproliferative activity against human HeLa cells after 4 days by coulter counter analysis
    		[PMID: 24773591]
    HeLa IC50
    0.011 μM
    Compound: Colchicine
    Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 72 hrs by SRB assay
    Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 72 hrs by SRB assay
    		[PMID: 30883116]
    HeLa IC50
    0.013 μM
    Compound: Colchicine
    Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 48 hrs by MTT assay
    Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 48 hrs by MTT assay
    		[PMID: 31185410]
    HeLa IC50
    0.02 μM
    Compound: Colchicine
    Cytotoxicity against human HeLa cells assessed as reduction in cell growth measured after 48 hrs by WST-8 assay
    Cytotoxicity against human HeLa cells assessed as reduction in cell growth measured after 48 hrs by WST-8 assay
    		[PMID: 27665177]
    HeLa IC50
    0.023 μM
    Compound: Colchicine
    In vitro inhibitory activity against HeLa/KB cells using XTT proliferation assay.
    In vitro inhibitory activity against HeLa/KB cells using XTT proliferation assay.
    		[PMID: 11741473]
    HeLa IC50
    0.027 μM
    Compound: Colchicine
    Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
    Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
    		[PMID: 30106297]
    HeLa EC50
    0.027 μM
    Compound: Colchicine
    Antiproliferative activity against human HeLa cells after 96 hrs by MTT assay
    Antiproliferative activity against human HeLa cells after 96 hrs by MTT assay
    		[PMID: 29055869]
    HeLa IC50
    0.028 μM
    Compound: Colchicine
    Antiproliferative activity against human HeLa cells assessed as inhibition of cell proliferation after 4 days by Coulter counter based cell counting method
    Antiproliferative activity against human HeLa cells assessed as inhibition of cell proliferation after 4 days by Coulter counter based cell counting method
    		[PMID: 25282265]
    HeLa IC50
    0.03 μM
    Compound: Colchicine
    Antiproliferative activity against human HeLa cells assessed as reduction in cell growth after 48 hrs by MTT assay
    Antiproliferative activity against human HeLa cells assessed as reduction in cell growth after 48 hrs by MTT assay
    		[PMID: 31753698]
    HeLa EC50
    0.03 μM
    Compound: Colchicine
    Induction of mitotic arrest in human HeLa cells assessed as reduction in cell density by immunofluorescence staining
    Induction of mitotic arrest in human HeLa cells assessed as reduction in cell density by immunofluorescence staining
    		[PMID: 22564383]
    HeLa IC50
    0.037 μM
    Compound: COL
    Cytotoxicity against human HeLa cells after 3 days by SRB assay
    Cytotoxicity against human HeLa cells after 3 days by SRB assay
    		[PMID: 26927488]
    HeLa EC50
    0.039 μM
    Compound: Colchicine
    Cytotoxicity against human HeLa cells after 48 hrs by luminescence cell viability assay
    Cytotoxicity against human HeLa cells after 48 hrs by luminescence cell viability assay
    		[PMID: 18684625]
    HeLa GI50
    0.04 μM
    Compound: Colchicine
    Antiproliferative activity against human HeLa cells after 48 hrs by SRB assay
    Antiproliferative activity against human HeLa cells after 48 hrs by SRB assay
    		[PMID: 25827522]
    HeLa IC50
    0.042 μM
    Compound: Col
    Antiproliferation activity against human HeLa cells assessed as reduction in cell growth measured after 48 to 72 hrs by CCK-8 assay
    Antiproliferation activity against human HeLa cells assessed as reduction in cell growth measured after 48 to 72 hrs by CCK-8 assay
    		[PMID: 35339837]
    HeLa IC50
    0.051 μM
    Compound: Colchicine
    Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
    Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
    		[PMID: 30093295]
    HeLa IC50
    0.058 μM
    Compound: 1
    Cytotoxicity against human HeLa cells after 24 to 72 hrs by Cell Titer Blue assay
    Cytotoxicity against human HeLa cells after 24 to 72 hrs by Cell Titer Blue assay
    		[PMID: 32432867]
    HeLa IC50
    0.081 μM
    Compound: Colchicine
    Antiproliferative activity against human HeLa cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK-8 assay
    Antiproliferative activity against human HeLa cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK-8 assay
    		[PMID: 32650183]
    HeLa IC50
    0.083 μM
    Compound: Colchicine
    Antiproliferative activity against human HeLa cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
    Antiproliferative activity against human HeLa cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
    		[PMID: 33788562]
    HeLa IC50
    0.1 μg/mL
    Compound: colchicine
    Cytotoxicity against human HeLa cells after 48 hrs by MTT assay
    Cytotoxicity against human HeLa cells after 48 hrs by MTT assay
    		[PMID: 15620246]
    HeLa IC50
    0.1 μg/mL
    Compound: Colchicine
    Cytotoxicity against human HeLa cells after 48 hrs by MTT assay
    Cytotoxicity against human HeLa cells after 48 hrs by MTT assay
    		[PMID: 15165134]
    HeLa IC50
    0.1 μM
    Compound: Colchicine
    Cytotoxicity against human HeLa cells after 48 hrs
    Cytotoxicity against human HeLa cells after 48 hrs
    		[PMID: 23022053]
    HeLa IC50
    0.103 μM
    Compound: Colchicine
    Antiproliferative activity against human HeLa assessed as reduction in cell viability measured after 48 hrs by MTT assay
    Antiproliferative activity against human HeLa assessed as reduction in cell viability measured after 48 hrs by MTT assay
    		[PMID: 34175541]
    HeLa IC50
    0.138 μM
    Compound: Colchicine
    Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
    Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
    		[PMID: 34968813]
    HeLa IC50
    0.15 μM
    Compound: Colchicine
    Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth incubated for 24 hrs in presence of foetal bovine serum by MTT assay
    Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth incubated for 24 hrs in presence of foetal bovine serum by MTT assay
    		[PMID: 35367708]
    HeLa IC50
    0.28 μM
    Compound: Col
    Antiproliferative activity against human HeLa cells assessed as inhibition of cell proliferation incubated for 24 hrs by MTT assay
    Antiproliferative activity against human HeLa cells assessed as inhibition of cell proliferation incubated for 24 hrs by MTT assay
    		[PMID: 36760739]
    HeLa IC50
    0.36 μM
    Compound: Colchicine
    Antiproliferative activity against human HeLa cells after 24 hrs by MTT assay
    Antiproliferative activity against human HeLa cells after 24 hrs by MTT assay
    		[PMID: 30606674]
    HeLa IC50
    0.45 μM
    Compound: Colchicine
    Antiproliferative activity against human HeLa cells measured after 24 hrs by MTT assay
    Antiproliferative activity against human HeLa cells measured after 24 hrs by MTT assay
    		10.1039/C6MD00255B
    HeLa IC50
    0.5 μM
    Compound: Colchicine
    Antiproliferative activity against human HeLa cells by SRB assay
    Antiproliferative activity against human HeLa cells by SRB assay
    		[PMID: 28988750]
    HeLa IC50
    0.54 μM
    Compound: Colchicine
    Cytotoxicity against human HeLa cells after 48 hrs by MTT assay
    Cytotoxicity against human HeLa cells after 48 hrs by MTT assay
    		[PMID: 25499929]
    HeLa IC50
    0.704 μM
    Compound: Colchicine
    Cytotoxicity against human HeLa cells assessed as growth inhibition after 72 hrs by CCK-8 assay
    Cytotoxicity against human HeLa cells assessed as growth inhibition after 72 hrs by CCK-8 assay
    		[PMID: 25091926]
    HeLa IC50
    1.3 nM
    Compound: 1
    Antiproliferative activity against human HeLa cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay
    Antiproliferative activity against human HeLa cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay
    		[PMID: 32827941]
    HeLa IC50
    10.2 μM
    Compound: Colchicine
    Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 48 hrs by MTT assay
    Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 48 hrs by MTT assay
    		[PMID: 30878833]
    HeLa IC50
    14 nM
    Compound: Colchicine
    Antiproliferative activity against human HeLa cells after 2 days by MTT assay
    Antiproliferative activity against human HeLa cells after 2 days by MTT assay
    		[PMID: 29604583]
    HeLa IC50
    16 nM
    Compound: Colchicine
    Antiproliferative activity against human HeLa cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
    Antiproliferative activity against human HeLa cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
    		[PMID: 35084853]
    HeLa IC50
    17.79 μM
    Compound: Colchicine
    Anticancer activity against human HeLa cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay
    Anticancer activity against human HeLa cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay
    		[PMID: 35367708]
    HeLa IC50
    19.5 nM
    Compound: Colchicine
    Antiproliferative activity against human HeLa cells incubated for 72 hrs by MTT assay
    Antiproliferative activity against human HeLa cells incubated for 72 hrs by MTT assay
    		[PMID: 34648295]
    HeLa IC50
    2.54 μM
    Compound: Colchicine
    Antiproliferative activity against human HeLa cells after 24 hrs by MTT assay
    Antiproliferative activity against human HeLa cells after 24 hrs by MTT assay
    		[PMID: 29268130]
    HeLa IC50
    20.2 nM
    Compound: 1
    Cytotoxicity against human HeLa cells after 48 hrs by WST-8 assay
    Cytotoxicity against human HeLa cells after 48 hrs by WST-8 assay
    		[PMID: 22727370]
    HeLa IC50
    21 μg/mL
    Compound: Colchicine
    Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
    Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
    		[PMID: 11473441]
    HeLa IC50
    21.8 nM
    Compound: 1
    Cytotoxicity against human HeLa cells after 48 hrs by Celltiter-Glo luminescent cell viability assay
    Cytotoxicity against human HeLa cells after 48 hrs by Celltiter-Glo luminescent cell viability assay
    		[PMID: 26985296]
    HeLa IC50
    28 nM
    Compound: 1
    Cytotoxicity against human HeLa cells assessed as growth inhibition after 48 hrs by MTT assay
    Cytotoxicity against human HeLa cells assessed as growth inhibition after 48 hrs by MTT assay
    		[PMID: 23214452]
    HeLa EC50
    32.5 nM
    Compound: 1a
    Antimitotic activity in human HeLa cells assessed as cell density loss after 24 hrs by Hoechst 33342 staining
    Antimitotic activity in human HeLa cells assessed as cell density loss after 24 hrs by Hoechst 33342 staining
    		[PMID: 23524161]
    HeLa IC50
    37.38 nM
    Compound: 3
    Cytotoxicity against human HeLa cells after 72 hrs by CCK-8 assay
    Cytotoxicity against human HeLa cells after 72 hrs by CCK-8 assay
    		[PMID: 23360369]
    HeLa IC50
    55 nM
    Compound: Colchicine
    Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
    Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
    		[PMID: 33234343]
    HeLa IC50
    8.2 nM
    Compound: colchicine
    Cytotoxicity against human HeLa cells after 96 hrs by MTT assay
    Cytotoxicity against human HeLa cells after 96 hrs by MTT assay
    		[PMID: 23176628]
    HeLa IC50
    8.89 nM
    Compound: Colchicine
    Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay
    Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay
    		[PMID: 30197030]
    HeLa IC50
    9.5 nM
    Compound: Colchicine
    Antiproliferative activity against human HeLa cells after 72 hrs by MTS assay
    Antiproliferative activity against human HeLa cells after 72 hrs by MTS assay
    		[PMID: 30099258]
    HeLa IC50
    9.7 nM
    Compound: colchicine
    Cytotoxicity against human HeLa cells expressing class 3 tubulin after 96 hrs by MTT assay
    Cytotoxicity against human HeLa cells expressing class 3 tubulin after 96 hrs by MTT assay
    		[PMID: 23176628]
    Hep 3B2 IC50
    0.014 μM
    Compound: Colchicine
    Cytotoxicity against human Hep3B cells assessed as growth inhibition after 72 hrs by MTT assay
    Cytotoxicity against human Hep3B cells assessed as growth inhibition after 72 hrs by MTT assay
    		[PMID: 25805446]
    Hep 3B2 IC50
    0.14 μM
    Compound: Colchicine
    Antiproliferative activity against human Hep3B cells measured after 72 hrs by MTT assay
    Antiproliferative activity against human Hep3B cells measured after 72 hrs by MTT assay
    		[PMID: 35193066]
    Hepatocyte CC50
    152.78 μM
    Compound: Colchicine
    Cytotoxicity against mouse primary hepatocytes after 24 hrs by MTT assay
    Cytotoxicity against mouse primary hepatocytes after 24 hrs by MTT assay
    		[PMID: 30606674]
    HepG2 IC50
    > 10 μM
    Compound: Colchicine
    Growth inhibition of human HepG2 cells after 72 hrs by MTT assay
    Growth inhibition of human HepG2 cells after 72 hrs by MTT assay
    		[PMID: 23747810]
    HepG2 IC50
    0.002 μM
    Compound: Colchicine
    Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
    Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
    		[PMID: 36511661]
    HepG2 IC50
    0.019 μM
    Compound: 1
    Growth inhibition of human HepG2 cells incubated for 72 hrs by MTT assay
    Growth inhibition of human HepG2 cells incubated for 72 hrs by MTT assay
    		[PMID: 27172319]
    HepG2 IC50
    0.02 μM
    Compound: Colchicine
    Cytotoxicity against human HepG2 cells after 48 hrs
    Cytotoxicity against human HepG2 cells after 48 hrs
    		[PMID: 23022053]
    HepG2 IC50
    0.027 μM
    Compound: Colchicine
    Cytotoxicity against human HepG2 cells assessed as growth inhibition after 72 hrs by MTT assay
    Cytotoxicity against human HepG2 cells assessed as growth inhibition after 72 hrs by MTT assay
    		[PMID: 25805446]
    HepG2 EC50
    0.031 μM
    Compound: Colchicine
    Cytotoxicity against human HepG2 cells after 48 hrs by luminescence cell viability assay
    Cytotoxicity against human HepG2 cells after 48 hrs by luminescence cell viability assay
    		[PMID: 18684625]
    HepG2 IC50
    0.035 μM
    Compound: COL
    Antiproliferative activity against human HepG2 cells after 48 hrs by SRB method
    Antiproliferative activity against human HepG2 cells after 48 hrs by SRB method
    		[PMID: 25061803]
    HepG2 IC50
    0.042 μM
    Compound: Colchicine
    Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay
    Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay
    		[PMID: 28863359]
    HepG2 IC50
    0.046 μM
    Compound: Colchicine
    Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
    Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
    		[PMID: 30093295]
    HepG2 IC50
    0.05 μM
    Compound: Colchicin
    Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay
    Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay
    		[PMID: 21724404]
    HepG2 IC50
    0.054 μM
    Compound: Colchicine
    Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
    Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
    		[PMID: 36455508]
    HepG2 IC50
    0.064 μM
    Compound: Colchicine
    Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
    Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
    		[PMID: 34968813]
    HepG2 IC50
    0.078 μM
    Compound: Colchicine
    Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay
    Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay
    		[PMID: 30106297]
    HepG2 IC50
    0.1239 μM
    Compound: Colchicine
    Antiproliferative activity against human HepG2 cells after 48 hrs by SRB assay
    Antiproliferative activity against human HepG2 cells after 48 hrs by SRB assay
    		[PMID: 27744186]
    HepG2 IC50
    0.23 μg/mL
    Compound: Colchicine
    Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
    Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
    		[PMID: 21440448]
    HepG2 IC50
    0.23 μM
    Compound: Colchicine
    Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
    Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
    		[PMID: 22512906]
    HepG2 IC50
    0.42 μM
    Compound: Colchicine
    Antiproliferative activity against human HepG2 cells after 24 hrs by MTT assay
    Antiproliferative activity against human HepG2 cells after 24 hrs by MTT assay
    		[PMID: 30606674]
    HepG2 IC50
    0.64 μM
    Compound: Colchicine
    Antiproliferative activity against human HepG2 cells measured after 24 hrs by MTT assay
    Antiproliferative activity against human HepG2 cells measured after 24 hrs by MTT assay
    		10.1039/C6MD00255B
    HepG2 IC50
    1.47 μM
    Compound: Colchicine
    Antiproliferative activity against human HepG2 cells incubated for 48 hrs by MTT assay
    Antiproliferative activity against human HepG2 cells incubated for 48 hrs by MTT assay
    		[PMID: 32035399]
    HepG2 IC50
    1.71 μM
    Compound: Colchicine
    Cytotoxicity against human HepG2 cells assessed as growth inhibition after 72 hrs by CCK-8 assay
    Cytotoxicity against human HepG2 cells assessed as growth inhibition after 72 hrs by CCK-8 assay
    		[PMID: 25091926]
    HepG2 IC50
    1.8 μM
    Compound: Colchicine
    Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
    Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
    		[PMID: 25778766]
    HepG2 IC50
    1.8 μM
    Compound: Colchicin
    Cytotoxicity against human HepG2 cells assessed as growth inhibition after 48 hrs by MTT assay
    Cytotoxicity against human HepG2 cells assessed as growth inhibition after 48 hrs by MTT assay
    		[PMID: 23735826]
    HepG2 IC50
    1.9 μM
    Compound: Colchicin
    Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
    Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
    		[PMID: 21576023]
    HepG2 GI50
    10.5 μM
    Compound: Colchicine
    Growth inhibition of human HepG2 cells assessed as inhibition of cell proliferation after 24 hrs by MTT assay
    Growth inhibition of human HepG2 cells assessed as inhibition of cell proliferation after 24 hrs by MTT assay
    		[PMID: 26070164]
    HepG2 IC50
    13.6 nM
    Compound: Colchicine
    Antiproliferative activity against human HepG2 cells incubated for 72 hrs by MTT assay
    Antiproliferative activity against human HepG2 cells incubated for 72 hrs by MTT assay
    		[PMID: 34648295]
    HepG2 IC50
    4.6 μM
    Compound: Colchicine
    Antiproliferative activity against human HepG2 cells measured after 48 hrs by MTT assay
    Antiproliferative activity against human HepG2 cells measured after 48 hrs by MTT assay
    		[PMID: 30690300]
    HepG2 IC50
    4.65 μM
    Compound: Colchicine
    Anticancer activity against human HepG2 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay
    Anticancer activity against human HepG2 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay
    		[PMID: 35367708]
    HepG2 IC50
    4.65 μM
    Compound: Colchicine
    Antiproliferative activity against human HepG2 cells after 24 hrs by MTT assay
    Antiproliferative activity against human HepG2 cells after 24 hrs by MTT assay
    		[PMID: 29268130]
    HepG2 IC50
    42 nM
    Compound: colchicine
    Antiproliferative activity against human HepG2 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay
    Antiproliferative activity against human HepG2 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay
    		[PMID: 25208345]
    HepG2 IC50
    42.8 nM
    Compound: 1
    Antiproliferative activity against human HepG2 cells after 24 hrs by MTT assay
    Antiproliferative activity against human HepG2 cells after 24 hrs by MTT assay
    		[PMID: 27213819]
    HepG2 IC50
    45 nM
    Compound: Colchicine
    Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
    Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
    		[PMID: 33234343]
    HepG2 IC50
    46.74 nM
    Compound: 3
    Cytotoxicity against human HepG2 cells after 72 hrs by CCK-8 assay
    Cytotoxicity against human HepG2 cells after 72 hrs by CCK-8 assay
    		[PMID: 23360369]
    HepG2 IC50
    5.8 μM
    Compound: Colchicine
    Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay
    Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay
    		[PMID: 30878833]
    HGC-27 IC50
    0.003 μM
    Compound: Colchicine
    Antiproliferative activity against human HGC-27 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
    Antiproliferative activity against human HGC-27 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
    		[PMID: 36511661]
    HL-60 IC50
    > 100 μM
    Compound: 1
    Cytotoxicity against vincristine-resistant human HL60 cells after 72 hrs MTS assay
    Cytotoxicity against vincristine-resistant human HL60 cells after 72 hrs MTS assay
    		[PMID: 20411988]
    HL-60 EC50
    0.0086 μM
    Compound: Colchicine
    Antiproliferative activity against human HL60 cells after 96 hrs by MTT assay
    Antiproliferative activity against human HL60 cells after 96 hrs by MTT assay
    		[PMID: 29055869]
    HL-60 IC50
    0.053 μM
    Compound: 1
    Cytotoxicity against human HL60 cells after 72 hrs MTS assay
    Cytotoxicity against human HL60 cells after 72 hrs MTS assay
    		[PMID: 20411988]
    HL-60 IC50
    1.6 μg/mL
    Compound: colchicine
    Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
    Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
    		[PMID: 15620246]
    HL-60 IC50
    1.6 μg/mL
    Compound: Colchicine
    Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
    Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
    		[PMID: 15165134]
    HMEC IC50
    8.1 μM
    Compound: Colchicine
    Antiproliferative activity against human HMEC cells assessed as reduction in cell viability after 48 hrs by MTT assay
    Antiproliferative activity against human HMEC cells assessed as reduction in cell viability after 48 hrs by MTT assay
    		[PMID: 30878833]
    HMEC-1 IC50
    0.0038 μM
    Compound: 5
    Antiproliferative activity against human HMEC1 cells measured after 4 days by Coulter counter method
    Antiproliferative activity against human HMEC1 cells measured after 4 days by Coulter counter method
    		[PMID: 30921759]
    HMEC-1 IC50
    0.0038 μM
    Compound: Colchicine
    Antiproliferative activity against human HMEC1 cells after 4 days by coulter counting method
    Antiproliferative activity against human HMEC1 cells after 4 days by coulter counting method
    		[PMID: 29471122]
    HMEC-1 IC50
    0.0038 μM
    Compound: Colchicine
    Antiproliferative activity against human HMEC1 cells assessed as inhibition of cell proliferation after 4 days by Coulter counter based cell counting method
    Antiproliferative activity against human HMEC1 cells assessed as inhibition of cell proliferation after 4 days by Coulter counter based cell counting method
    		[PMID: 25282265]
    HMEC-1 IC50
    0.0038 μM
    Compound: 1, colch
    Antiproliferative activity against HMEC1 after 4 days by coulter counter analysis
    Antiproliferative activity against HMEC1 after 4 days by coulter counter analysis
    		[PMID: 24773591]
    HN-6 IC50
    19.5 nM
    Compound: Colchicine
    Antiproliferative activity against human HN-6 cells assessed as cell growth inhibition incubated for 72 hrs by CCK-8 assay
    Antiproliferative activity against human HN-6 cells assessed as cell growth inhibition incubated for 72 hrs by CCK-8 assay
    		[PMID: 35576703]
    HT-1080 IC50
    0.042 μM
    Compound: 1
    Antiproliferative activity against human HT1080 cells after 72 hrs by MTT assay
    Antiproliferative activity against human HT1080 cells after 72 hrs by MTT assay
    		[PMID: 30245397]
    HT-1080 IC50
    1.1 nM
    Compound: Col
    Antiproliferative activity against human HT1080 after 48 hrs by SRB assay
    Antiproliferative activity against human HT1080 after 48 hrs by SRB assay
    		[PMID: 21920638]
    HT-1080 IC50
    1.1 nM
    Compound: Col
    Antiproliferative activity against human HT1080 cells after 48 hrs by sulforhodamine B assay
    Antiproliferative activity against human HT1080 cells after 48 hrs by sulforhodamine B assay
    		[PMID: 21604746]
    HT-1080 IC50
    15.38 nM
    Compound: 3
    Cytotoxicity against human HT1080 cells after 72 hrs by CCK-8 assay
    Cytotoxicity against human HT1080 cells after 72 hrs by CCK-8 assay
    		[PMID: 23360369]
    HT-29 IC50
    < 1 μM
    Compound: Colchicine
    Antiproliferative activity against human HT-29 cells after 48 hrs by MTT assay
    Antiproliferative activity against human HT-29 cells after 48 hrs by MTT assay
    		[PMID: 20833451]
    HT-29 GI50
    0.004 μM
    Compound: COL
    Antiproliferative activity against human HT29 cells after 48 hrs by sulforhodamine B method
    Antiproliferative activity against human HT29 cells after 48 hrs by sulforhodamine B method
    		[PMID: 18617414]
    HT-29 GI50
    0.004 μM
    Compound: colchicine
    Growth inhibition of human HT29 cells after 48 hrs by sulforhodamine B assay
    Growth inhibition of human HT29 cells after 48 hrs by sulforhodamine B assay
    		[PMID: 18579387]
    HT-29 GI50
    0.004 μM
    Compound: colchicine
    Growth inhibition of human HT29 cells after 48 hrs
    Growth inhibition of human HT29 cells after 48 hrs
    		[PMID: 17498960]
    HT-29 IC50
    0.008 μM
    Compound: Colchicine
    Antiproliferative activity against human HT-29 cells by MTS assay
    Antiproliferative activity against human HT-29 cells by MTS assay
    		10.1039/C3MD00077J
    HT-29 IC50
    0.008 μM
    Compound: 1
    Cytotoxicity against human HT-29 cells after 96 hrs using tetracolor one
    Cytotoxicity against human HT-29 cells after 96 hrs using tetracolor one
    		[PMID: 24900316]
    HT-29 IC50
    0.01 μM
    Compound: Colchicine
    Cytotoxicity against human HT-29 cells after 96 hrs by MTT assay
    Cytotoxicity against human HT-29 cells after 96 hrs by MTT assay
    		[PMID: 22542017]
    HT-29 IC50
    0.018 μM
    Compound: Colchicine
    Antiproliferative activity against human HT-29 cells over expressing GLUT1 measured after 72 hrs by MTT assay
    Antiproliferative activity against human HT-29 cells over expressing GLUT1 measured after 72 hrs by MTT assay
    		[PMID: 35193066]
    HT-29 IC50
    0.02 μM
    Compound: Colchicine
    Cytotoxicity against human HT-29 cells by MTT assay
    Cytotoxicity against human HT-29 cells by MTT assay
    		[PMID: 23425970]
    HT-29 IC50
    0.042 μM
    Compound: 1
    Cytotoxicity against human HT-29 cells incubated for 48 hrs by MTT assay
    Cytotoxicity against human HT-29 cells incubated for 48 hrs by MTT assay
    		[PMID: 32432867]
    HT-29 IC50
    0.05 μM
    Compound: colchicine
    Cytotoxicity against human HT-29 cells after 3 days by MTT assay
    Cytotoxicity against human HT-29 cells after 3 days by MTT assay
    		[PMID: 25426924]
    HT-29 IC50
    0.07 μM
    Compound: Colchicine
    Growth inhibition of human HT-29 cells after 72 hrs by MTT assay
    Growth inhibition of human HT-29 cells after 72 hrs by MTT assay
    		[PMID: 23747810]
    HT-29 IC50
    0.22 μM
    Compound: Col
    Antiproliferative activity against human HT-29 cells assessed as inhibition of cell proliferation incubated for 24 hrs by MTT assay
    Antiproliferative activity against human HT-29 cells assessed as inhibition of cell proliferation incubated for 24 hrs by MTT assay
    		[PMID: 36760739]
    HT-29 IC50
    0.25 μM
    Compound: Colchicine
    Cytotoxicity against human HT-29 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
    Cytotoxicity against human HT-29 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
    		[PMID: 35447432]
    HT-29 IC50
    1.81 μM
    Compound: Colchicine
    Antiproliferative activity against human HT29 cells incubated for 48 hrs by MTT assay
    Antiproliferative activity against human HT29 cells incubated for 48 hrs by MTT assay
    		[PMID: 32035399]
    HT-29 IC50
    10 nM
    Compound: Colchicine
    Cytotoxicity against human HT-29 cells after 72 hrs by methylene blue dye assay
    Cytotoxicity against human HT-29 cells after 72 hrs by methylene blue dye assay
    		[PMID: 19586033]
    HT-29 IC50
    10 nM
    Compound: 1
    Growth inhibition of human HT-29 cells after 72 hrs by methylene blue dye assay
    Growth inhibition of human HT-29 cells after 72 hrs by methylene blue dye assay
    		[PMID: 19053773]
    HT-29 IC50
    11.5 nM
    Compound: Colchicine
    Antiproliferative activity against human HT-29 cells after 72 hrs by MTS assay
    Antiproliferative activity against human HT-29 cells after 72 hrs by MTS assay
    		[PMID: 30099258]
    HT-29 IC50
    12.8 nM
    Compound: colchicine
    Cytotoxicity against human HT-29 cells after 72 hrs by methylene blue assay
    Cytotoxicity against human HT-29 cells after 72 hrs by methylene blue assay
    		[PMID: 24657567]
    HT-29 IC50
    13 nM
    Compound: Colchicine
    Antiproliferative activity against human HT-29 cells after 2 days by MTT assay
    Antiproliferative activity against human HT-29 cells after 2 days by MTT assay
    		[PMID: 29604583]
    HT-29 IC50
    13.2 nM
    Compound: 3
    Antiproliferative activity against human HT-29 cells after 72 hrs by methylene blue dye assay
    Antiproliferative activity against human HT-29 cells after 72 hrs by methylene blue dye assay
    		[PMID: 20148562]
    HT-29 IC50
    15 nM
    Compound: 5
    Antiproliferative activity against human HT-29 cells after 72 hrs by methylene blue assay
    Antiproliferative activity against human HT-29 cells after 72 hrs by methylene blue assay
    		[PMID: 21641700]
    HT-29 IC50
    15.2 nM
    Compound: 6
    Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth after 72 hrs by methylene blue dye assay
    Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth after 72 hrs by methylene blue dye assay
    		10.1039/C0MD00052C
    HT-29 IC50
    15.2 nM
    Compound: 1
    Cytotoxicity against human HT-29 cells assessed as growth inhibition after 72 hrs by methylene blue staining-based assay
    Cytotoxicity against human HT-29 cells assessed as growth inhibition after 72 hrs by methylene blue staining-based assay
    		[PMID: 24106982]
    HT-29 IC50
    16 nM
    Compound: 1
    Cytotoxicity against human HT-29 cells after 48 hrs by resazurin assay
    Cytotoxicity against human HT-29 cells after 48 hrs by resazurin assay
    		[PMID: 22727370]
    HT-29 IC50
    16 nM
    Compound: colchicine
    Cytotoxicity against human HT-29 cells after 48 hrs using resazurin by microplate fluorometer analysis
    Cytotoxicity against human HT-29 cells after 48 hrs using resazurin by microplate fluorometer analysis
    		[PMID: 22185476]
    HT-29 IC50
    16.2 nM
    Compound: 1
    Growth inhibition of human HT-29 cells after 72 hrs by methylene blue assay
    Growth inhibition of human HT-29 cells after 72 hrs by methylene blue assay
    		[PMID: 22060033]
    HT-29 IC50
    16.6 nM
    Compound: Colchicine
    Cytotoxicity against human HT-29 cells after 72 hrs by XTT/PMS method
    Cytotoxicity against human HT-29 cells after 72 hrs by XTT/PMS method
    		[PMID: 21106379]
    HT-29 IC50
    18 nM
    Compound: 1
    Cytotoxicity against human HT-29 cells assessed as growth inhibition after 48 hrs by MTT assay
    Cytotoxicity against human HT-29 cells assessed as growth inhibition after 48 hrs by MTT assay
    		[PMID: 23214452]
    HT-29 IC50
    18 nM
    Compound: Colchicine
    Antiproliferative activity against human HT-29 cells after 96 hrs by MTT assay
    Antiproliferative activity against human HT-29 cells after 96 hrs by MTT assay
    		[PMID: 2778449]
    HT-29 IC50
    20.5 nM
    Compound: Colchicine
    Antiproliferative activity against human HT-29 cells incubated for 72 hrs by MTT assay
    Antiproliferative activity against human HT-29 cells incubated for 72 hrs by MTT assay
    		[PMID: 34648295]
    HT-29 IC50
    21.9 nM
    Compound: Colchicine
    Antiproliferative activity against human HT-29 cells after 72 hrs by sulforhodamine B assay
    Antiproliferative activity against human HT-29 cells after 72 hrs by sulforhodamine B assay
    		[PMID: 21480626]
    HT-29 IC50
    5.19 μM
    Compound: Colchicine
    Antiproliferative activity against human HT-29 cells assessed as inhibition of cell proliferation measured after 48 hrs by MTT assay
    Antiproliferative activity against human HT-29 cells assessed as inhibition of cell proliferation measured after 48 hrs by MTT assay
    		[PMID: 32768647]
    HT-29 IC50
    50 nM
    Compound: Colchicine
    Antiproliferative activity against human HT-29 cells after 2 days by MTT assay
    Antiproliferative activity against human HT-29 cells after 2 days by MTT assay
    		[PMID: 29550732]
    HT-29 IC50
    50 nM
    Compound: Colchicine
    Cytotoxicity against human HT-29 cells assessed as growth inhibition after 72 hrs by MTT assay
    Cytotoxicity against human HT-29 cells assessed as growth inhibition after 72 hrs by MTT assay
    		[PMID: 27915168]
    HT-29 IC50
    69.25 nM
    Compound: colchicine
    Cytotoxicity against human HT-29 cells after 96 hrs by MTT assay
    Cytotoxicity against human HT-29 cells after 96 hrs by MTT assay
    		[PMID: 23176628]
    HT-29 IC50
    8.2 nM
    Compound: 1
    Cytotoxicity against human HT-29 cells assessed as inhibition of cell proliferation after 96 hrs
    Cytotoxicity against human HT-29 cells assessed as inhibition of cell proliferation after 96 hrs
    		10.1039/C3MD00287J
    HT-29 IC50
    8.2 nM
    Compound: 1
    Cytotoxicity against human HT-29 cells after 96 hrs by microplate reader analysis
    Cytotoxicity against human HT-29 cells after 96 hrs by microplate reader analysis
    		10.1039/C2MD20250F
    HT-29 IC50
    9.3 nM
    Compound: 1
    Cytotoxicity against human HT-29 cells after 48 hrs by XTT assay
    Cytotoxicity against human HT-29 cells after 48 hrs by XTT assay
    		[PMID: 22727370]
    Huh-7 IC50
    26.1 nM
    Compound: Colchicine
    Antiproliferative activity against human Huh-7 cells incubated for 72 hrs by MTT assay
    Antiproliferative activity against human Huh-7 cells incubated for 72 hrs by MTT assay
    		[PMID: 34648295]
    HUVEC IC50
    > 10000 nM
    Compound: Colchicine
    Antiproliferative activity against HUVEC after 72 hrs by MTS assay
    Antiproliferative activity against HUVEC after 72 hrs by MTS assay
    		[PMID: 30099258]
    HUVEC IC50
    0.012 μM
    Compound: Colchicine
    Cytotoxicity against HUVEC measured after 72 hrs by MTT assay
    Cytotoxicity against HUVEC measured after 72 hrs by MTT assay
    		[PMID: 35193066]
    HUVEC IC50
    0.023 μM
    Compound: 1a
    Cytotoxicity against human HUVEC cells after 24 hrs by MTT assay
    Cytotoxicity against human HUVEC cells after 24 hrs by MTT assay
    		[PMID: 23524161]
    HUVEC IC50
    0.025 μM
    Compound: Colchicine
    Anti-angiogenesis activity against HUVEC cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
    Anti-angiogenesis activity against HUVEC cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
    		[PMID: 36511661]
    HUVEC IC50
    13.2 nM
    Compound: 1
    Cytotoxicity against HUVEC assessed as cell viability after 4 days by MTS assay
    Cytotoxicity against HUVEC assessed as cell viability after 4 days by MTS assay
    		[PMID: 24210503]
    HUVEC GI50
    25 nM
    Compound: Colchicine
    Growth inhibition of HUVEC after 72 hrs by crystal violet staining-based assay
    Growth inhibition of HUVEC after 72 hrs by crystal violet staining-based assay
    		[PMID: 27690431]
    HUVEC IC50
    7.6 nM
    Compound: 3
    Antiproliferative activity against quesicent HUVECs after 48 hrs by CCK-8 assay
    Antiproliferative activity against quesicent HUVECs after 48 hrs by CCK-8 assay
    		[PMID: 23360369]
    HUVEC IC50
    8.91 nM
    Compound: 3
    Antiproliferative activity against activated HUVECs after 48 hrs by CCK-8 assay
    Antiproliferative activity against activated HUVECs after 48 hrs by CCK-8 assay
    		[PMID: 23360369]
    J774 IC50
    0.21 μM
    Compound: colchicine
    Cytotoxicity against mouse J774 cells by alamar blue assay
    Cytotoxicity against mouse J774 cells by alamar blue assay
    		[PMID: 17637068]
    Jurkat IC50
    0.0077 μM
    Compound: 1a
    Cytotoxicity against human Jurkat cells after 48 hrs by MTT assay
    Cytotoxicity against human Jurkat cells after 48 hrs by MTT assay
    		[PMID: 23524161]
    Jurkat IC50
    0.017 μM
    Compound: 1
    Cell cycle arrest in human Jurkat cells assessed as accumulation at G2/M phase after 24 hrs using propidium iodide staining by FACS analysis
    Cell cycle arrest in human Jurkat cells assessed as accumulation at G2/M phase after 24 hrs using propidium iodide staining by FACS analysis
    		[PMID: 21126027]
    Jurkat IC50
    13.5 nM
    Compound: 1
    Cytotoxicity against human Jurkat cells after 48 hrs by Celltiter-Glo luminescent cell viability assay
    Cytotoxicity against human Jurkat cells after 48 hrs by Celltiter-Glo luminescent cell viability assay
    		[PMID: 26985296]
    Jurkat IC50
    19.8 nM
    Compound: Colchicine
    Antiproliferative activity against human Jurkat cells after 72 hrs by MTS assay
    Antiproliferative activity against human Jurkat cells after 72 hrs by MTS assay
    		[PMID: 30099258]
    K562 IC50
    0.001 μM
    Compound: Colchicine
    Cytotoxicity against human K562 cells assessed as growth inhibition after 72 hrs by CCK-8 assay
    Cytotoxicity against human K562 cells assessed as growth inhibition after 72 hrs by CCK-8 assay
    		[PMID: 25091926]
    K562 IC50
    0.013 μM
    Compound: Colchicine
    Antiproliferative activity against human K562 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
    Antiproliferative activity against human K562 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
    		[PMID: 33212157]
    K562 GI50
    0.02 μM
    Compound: Colchicine
    Antiproliferative activity against human K562 cells after 48 hrs by MTT assay
    Antiproliferative activity against human K562 cells after 48 hrs by MTT assay
    		[PMID: 28763647]
    K562 IC50
    0.02 μM
    Compound: 18
    Growth inhibition of human K562 cells after 48 hrs by trypan blue assay
    Growth inhibition of human K562 cells after 48 hrs by trypan blue assay
    		[PMID: 21530013]
    K562 IC50
    0.02 μM
    Compound: Colchicine
    Growth inhibition of human K562 cells after 24 hrs by trypan blue exclusion assay
    Growth inhibition of human K562 cells after 24 hrs by trypan blue exclusion assay
    		[PMID: 23747810]
    K562 IC50
    0.02 μM
    Compound: Colchicine
    Growth inhibition of human K562 cells incubated for 24 hrs by trypan blue dye exclusion assay
    Growth inhibition of human K562 cells incubated for 24 hrs by trypan blue dye exclusion assay
    		[PMID: 26344588]
    K562 IC50
    0.02 μM
    Compound: colchicine
    Antiproliferative activity against human K562 cells after 48 hrs by Alamar blue dye based neubauer hemocytometer method
    Antiproliferative activity against human K562 cells after 48 hrs by Alamar blue dye based neubauer hemocytometer method
    		[PMID: 28045256]
    K562 IC50
    0.02 μM
    Compound: 2
    Antiproliferative activity against human K562 cells after 48 hrs by hemocytometer
    Antiproliferative activity against human K562 cells after 48 hrs by hemocytometer
    		[PMID: 21705223]
    K562 IC50
    0.02 μM
    Compound: colchicine
    Antiproliferative activity against human K562 cells after 48 hrs by hemocytometric analysis
    Antiproliferative activity against human K562 cells after 48 hrs by hemocytometric analysis
    		[PMID: 21563750]
    K562 IC50
    0.02 μM
    Compound: 2
    Cell growth inhibition of human K562 cells after 48 hrs
    Cell growth inhibition of human K562 cells after 48 hrs
    		[PMID: 20546980]
    K562 IC50
    0.02 μM
    Compound: 2
    Antiproliferative activity against human K562 cells after 48 hrs
    Antiproliferative activity against human K562 cells after 48 hrs
    		[PMID: 20537765]
    K562 IC50
    0.02 μM
    Compound: colchicine
    Antiproliferative activity against human K562 cells after 48 hrs
    Antiproliferative activity against human K562 cells after 48 hrs
    		[PMID: 19220018]
    K562 IC50
    0.02 μM
    Compound: colchicine
    Antiproliferative activity against human K562 cells after 48 hrs
    Antiproliferative activity against human K562 cells after 48 hrs
    		[PMID: 17973361]
    K562 IC50
    0.44 μM
    Compound: Colchicine
    Antiproliferative activity against human K562 cells incubated for 48 hrs by MTT assay
    Antiproliferative activity against human K562 cells incubated for 48 hrs by MTT assay
    		[PMID: 32035399]
    K562 IC50
    0.55 μM
    Compound: Colchicine
    Cytotoxicity against human K562 cells after 48 hrs
    Cytotoxicity against human K562 cells after 48 hrs
    		[PMID: 23022053]
    K562 IC50
    101.8 nM
    Compound: Colchicine
    Antiproliferative activity against human K562 cells measured after 72 hrs by SRB assay
    Antiproliferative activity against human K562 cells measured after 72 hrs by SRB assay
    		[PMID: 34794817]
    K562 IC50
    16 nM
    Compound: colchicine
    Antiproliferative activity against human K562 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay
    Antiproliferative activity against human K562 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay
    		[PMID: 25208345]
    K562 IC50
    19 μM
    Compound: 2
    Cytotoxicity against human K562 cells assessed as growth inhibition after 5 days by MTT assay
    Cytotoxicity against human K562 cells assessed as growth inhibition after 5 days by MTT assay
    		[PMID: 28143677]
    K562 IC50
    29 nM
    Compound: colchicine
    Cytotoxicity against human K562 cells after 72 hrs
    Cytotoxicity against human K562 cells after 72 hrs
    		[PMID: 19530698]
    K562 IC50
    6.59 μM
    Compound: Colchicine
    Antiproliferative activity against drug resistant human K562 cells incubated for 48 hrs by MTT assay
    Antiproliferative activity against drug resistant human K562 cells incubated for 48 hrs by MTT assay
    		[PMID: 32035399]
    K562 IC50
    6.8 nM
    Compound: Col
    Antiproliferative activity against human K562 after 48 hrs by SRB assay
    Antiproliferative activity against human K562 after 48 hrs by SRB assay
    		[PMID: 21920638]
    K562 IC50
    6.8 nM
    Compound: Col
    Antiproliferative activity against human K562 cells after 48 hrs by sulforhodamine B assay
    Antiproliferative activity against human K562 cells after 48 hrs by sulforhodamine B assay
    		[PMID: 21604746]
    K562/Adr IC50
    6553 nM
    Compound: Colchicine
    Antiproliferative activity against human K562/Adr cells measured after 72 hrs by SRB assay
    Antiproliferative activity against human K562/Adr cells measured after 72 hrs by SRB assay
    		[PMID: 34794817]
    KB ED50
    0.002 μg/mL
    Compound: colchicine
    Cytotoxicity against human epidermoid carcinoma of the nasopharyngeal cells (KB) using SRB assay.
    Cytotoxicity against human epidermoid carcinoma of the nasopharyngeal cells (KB) using SRB assay.
    		[PMID: 9544215]
    KB ED50
    0.0038 μg/mL
    Compound: 1
    Cytotoxicity against human KB cells after 2 days
    Cytotoxicity against human KB cells after 2 days
    		[PMID: 20542428]
    KB IC50
    0.01 μM
    Compound: colchicine
    Antiproliferative activity against human KB/HeLa cells by XTT assay
    Antiproliferative activity against human KB/HeLa cells by XTT assay
    		[PMID: 19220018]
    KB IC50
    0.013 μM
    Compound: Colchicine
    Cytotoxicity against human KB cells after 48 hrs by MTT assay
    Cytotoxicity against human KB cells after 48 hrs by MTT assay
    		[PMID: 20363142]
    KB IC50
    0.02 μM
    Compound: 1, colchicine
    Cytotoxicity against human KB cells after 72 hrs
    Cytotoxicity against human KB cells after 72 hrs
    		[PMID: 18503262]
    KB IC50
    0.03 μM
    Compound: 2
    Cytotoxicity against human KB/HeLa cells after 48 hrs by XTT assay
    Cytotoxicity against human KB/HeLa cells after 48 hrs by XTT assay
    		[PMID: 21705223]
    KB IC50
    0.03 μM
    Compound: 2
    Antiproliferative activity against human KB/HeLa cells after 48 hrs by XTT assay
    Antiproliferative activity against human KB/HeLa cells after 48 hrs by XTT assay
    		[PMID: 20537765]
    KB IC50
    0.03 μM
    Compound: colchicine
    Cytotoxicity against human KB/HeLa cells after 48 hrs by XTT assay
    Cytotoxicity against human KB/HeLa cells after 48 hrs by XTT assay
    		[PMID: 17973361]
    KB IC50
    0.03 μM
    Compound: 2
    Antiproliferative activity against KB/HeLa cells by XTT assay after 48 hrs
    Antiproliferative activity against KB/HeLa cells by XTT assay after 48 hrs
    		[PMID: 17181164]
    KB IC50
    0.03 μM
    Compound: 2 (Colchicine)
    Cytotoxic activity against cellular metabolic activity of Cervix KB/HeLa tumor cell line using XTT proliferation assay after incubation with the compound for 48 h
    Cytotoxic activity against cellular metabolic activity of Cervix KB/HeLa tumor cell line using XTT proliferation assay after incubation with the compound for 48 h
    		[PMID: 12852768]
    KB ED50
    0.2 μg/mL
    Compound: Colchicine
    Cytotoxicity against human KB cells after 3 days by SRB assay
    Cytotoxicity against human KB cells after 3 days by SRB assay
    		[PMID: 7528785]
    KB IC50
    10 nM
    Compound: 5
    Antiproliferative activity against human KB cells after 72 hrs by methylene blue assay
    Antiproliferative activity against human KB cells after 72 hrs by methylene blue assay
    		[PMID: 21641700]
    KB EC50
    10 nM
    Compound: Colchicine
    Cell cycle arrest in human KB cells assessed as accumulation of cells at G2/M phase after 24 hrs by propidium iodide-based FACScan
    Cell cycle arrest in human KB cells assessed as accumulation of cells at G2/M phase after 24 hrs by propidium iodide-based FACScan
    		[PMID: 21480626]
    KB IC50
    10.3 nM
    Compound: 6
    Antiproliferative activity against human KB cells assessed as inhibition of cell growth after 72 hrs by methylene blue dye assay
    Antiproliferative activity against human KB cells assessed as inhibition of cell growth after 72 hrs by methylene blue dye assay
    		10.1039/C0MD00052C
    KB IC50
    10.3 nM
    Compound: 1
    Growth inhibition of human KB cells after 72 hrs by methylene blue assay
    Growth inhibition of human KB cells after 72 hrs by methylene blue assay
    		[PMID: 22060033]
    KB IC50
    10.3 nM
    Compound: 1
    Cytotoxicity against human KB cells assessed as growth inhibition after 72 hrs by methylene blue staining-based assay
    Cytotoxicity against human KB cells assessed as growth inhibition after 72 hrs by methylene blue staining-based assay
    		[PMID: 24106982]
    KB IC50
    11 nM
    Compound: Colchicine
    Cytotoxicity against human KB cells after 72 hrs by methylene blue dye assay
    Cytotoxicity against human KB cells after 72 hrs by methylene blue dye assay
    		[PMID: 19586033]
    KB IC50
    11 nM
    Compound: 1
    Growth inhibition of human KB cells after 72 hrs by methylene blue dye assay
    Growth inhibition of human KB cells after 72 hrs by methylene blue dye assay
    		[PMID: 19053773]
    KB IC50
    11.4 nM
    Compound: 4
    Growth inhibition of human KB cells after 72 hrs by methylene blue dye assay
    Growth inhibition of human KB cells after 72 hrs by methylene blue dye assay
    		[PMID: 18588280]
    KB IC50
    116 nM
    Compound: 1
    Growth inhibition of human Pgp170 overexpressing multidrug resistant-KB-VIN10 cells after 72 hrs by methylene blue dye assay
    Growth inhibition of human Pgp170 overexpressing multidrug resistant-KB-VIN10 cells after 72 hrs by methylene blue dye assay
    		[PMID: 19053773]
    KB IC50
    117 nM
    Compound: Colchicine
    Cytotoxicity against KB-VIN 10 cell line by methylene blue dye assay
    Cytotoxicity against KB-VIN 10 cell line by methylene blue dye assay
    		[PMID: 17154496]
    KB IC50
    12 nM
    Compound: 3
    Antiproliferative activity against human KB cells after 72 hrs by methylene blue dye assay
    Antiproliferative activity against human KB cells after 72 hrs by methylene blue dye assay
    		[PMID: 20148562]
    KB IC50
    12 nM
    Compound: colchichine
    Growth inhibition of human KB cells after 72 hrs by methylene blue dye assay
    Growth inhibition of human KB cells after 72 hrs by methylene blue dye assay
    		[PMID: 17685504]
    KB IC50
    12.4 nM
    Compound: Colchicine
    Antiproliferative activity against human KB cells after 72 hrs by methylene blue assay
    Antiproliferative activity against human KB cells after 72 hrs by methylene blue assay
    		[PMID: 26160020]
    KB IC50
    12.4 nM
    Compound: colchicine
    Cytotoxicity against human KB cells after 72 hrs by methylene blue assay
    Cytotoxicity against human KB cells after 72 hrs by methylene blue assay
    		[PMID: 24657567]
    KB IC50
    13.3 nM
    Compound: Colchicine
    Cytotoxicity against human KB cell line by methylene blue dye assay
    Cytotoxicity against human KB cell line by methylene blue dye assay
    		[PMID: 17154496]
    KB EC50
    14 nM
    Compound: 2
    Cell cycle arrest in human KB/HeLa cells assessed as accumulation at G2/M phase after 24 hrs using propidium iodide staining by FACS analysis
    Cell cycle arrest in human KB/HeLa cells assessed as accumulation at G2/M phase after 24 hrs using propidium iodide staining by FACS analysis
    		[PMID: 20537765]
    KB EC50
    14 nM
    Compound: colchicine
    Cell cycle arrest in human KB/HeLa cells assessed as G2/M phase accumulation after 24 hrs by FACS analysis
    Cell cycle arrest in human KB/HeLa cells assessed as G2/M phase accumulation after 24 hrs by FACS analysis
    		[PMID: 19220018]
    KB EC50
    14 nM
    Compound: 2
    Cell cycle arrest in human KB/HeLa cells assessed as accumulation of cells at G2/M phase after 24 hrs by flow cytometry
    Cell cycle arrest in human KB/HeLa cells assessed as accumulation of cells at G2/M phase after 24 hrs by flow cytometry
    		[PMID: 21705223]
    KB EC50
    14 nM
    Compound: colchicine
    Cell cycle arrest in KB/HeLa cells assessed as accumulation at G2/M phase after 24 hrs by flow cytometric analysis
    Cell cycle arrest in KB/HeLa cells assessed as accumulation at G2/M phase after 24 hrs by flow cytometric analysis
    		[PMID: 17973361]
    KB EC50
    14 nM
    Compound: 2
    Cell cycle arrest in KB/HeLa cells by accumulation at G2/M phase
    Cell cycle arrest in KB/HeLa cells by accumulation at G2/M phase
    		[PMID: 17181164]
    KB IC50
    18.2 nM
    Compound: Colchicine
    Antiproliferative activity against human KB cells measured after 72 hrs by SRB assay
    Antiproliferative activity against human KB cells measured after 72 hrs by SRB assay
    		[PMID: 34794817]
    KB GI50
    4.2 nM
    Compound: Colchicine
    Growth inhibition of human KB cells after 72 hrs by MTS assay
    Growth inhibition of human KB cells after 72 hrs by MTS assay
    		[PMID: 26778612]
    KB 3-1 IC50
    0.018 μM
    Compound: Colchicine
    Cytotoxicity against human KB-3-1 cells after 72 hrs by MTT assay
    Cytotoxicity against human KB-3-1 cells after 72 hrs by MTT assay
    		[PMID: 23932339]
    KB 3-1 IC50
    0.02 μM
    Compound: 2
    Cytotoxicity against human KB3-1 cells after 68 hrs by MTT assay
    Cytotoxicity against human KB3-1 cells after 68 hrs by MTT assay
    		[PMID: 32243160]
    KB 3-1 IC50
    9 nM
    Compound: 1
    Antiproliferative activity against human KB-31 cells incubated for 96 hrs by spectrophotometric method
    Antiproliferative activity against human KB-31 cells incubated for 96 hrs by spectrophotometric method
    		[PMID: 32432867]
    KB-V1 IC50
    1340 nM
    Compound: Colchicine
    Antiproliferative activity against human KB-V1 cells measured after 72 hrs by SRB assay
    Antiproliferative activity against human KB-V1 cells measured after 72 hrs by SRB assay
    		[PMID: 34794817]
    KYSE-30 IC50
    0.28 μM
    Compound: Colchicine
    Antiproliferative activity against human KYSE-30 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK8 assay
    Antiproliferative activity against human KYSE-30 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK8 assay
    		[PMID: 34022412]
    KYSE-30 IC50
    0.28 μM
    Compound: Colchicine
    Antiproliferative activity against human KYSE-30 cells incubated for 48 hrs by CCK8 assay
    Antiproliferative activity against human KYSE-30 cells incubated for 48 hrs by CCK8 assay
    		[PMID: 33965530]
    KYSE-450 IC50
    0.077 μM
    Compound: Colchicine
    Antiproliferative activity against human KYSE-450 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
    Antiproliferative activity against human KYSE-450 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
    		[PMID: 35834904]
    KYSE-450 IC50
    0.122 μM
    Compound: Colchicine
    Antiproliferative activity against human KYSE-450 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
    Antiproliferative activity against human KYSE-450 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
    		[PMID: 35605363]
    KYSE-450 IC50
    0.22 μM
    Compound: Colchicine
    Antiproliferative activity against human KYSE-450 cells assessed as cell growth inhibition measured after 48 hrs by CCK8 assay
    Antiproliferative activity against human KYSE-450 cells assessed as cell growth inhibition measured after 48 hrs by CCK8 assay
    		[PMID: 34971875]
    L02 IC50
    2.3 μM
    Compound: Colchicine
    Cytotoxicity against human L02 cells assessed as inhibition of cell growth incubated for 24 hrs in presence of foetal bovine serum by MTT assay
    Cytotoxicity against human L02 cells assessed as inhibition of cell growth incubated for 24 hrs in presence of foetal bovine serum by MTT assay
    		[PMID: 35367708]
    L02 IC50
    26.5 nM
    Compound: Colchicine
    Antiproliferative activity against human LO2 cells after 48 hrs by MTT assay
    Antiproliferative activity against human LO2 cells after 48 hrs by MTT assay
    		[PMID: 28763646]
    L02 IC50
    3.01 μM
    Compound: Colchicine
    Antiproliferative activity against human LO2 cells after 24 hrs by MTT assay
    Antiproliferative activity against human LO2 cells after 24 hrs by MTT assay
    		[PMID: 29268130]
    L02 IC50
    5.74 μM
    Compound: Col
    Cytotoxicity against human L02 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay
    Cytotoxicity against human L02 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay
    		[PMID: 36760739]
    L02 CC50
    9.18 μM
    Compound: Colchicine
    Antiproliferative activity against human LO2 cells incubated for 48 hrs by MTT assay
    Antiproliferative activity against human LO2 cells incubated for 48 hrs by MTT assay
    		[PMID: 32035399]
    L02 IC50
    9.2 μM
    Compound: Colchicine
    Antiproliferative activity against human HL7702 cells assessed as reduction in cell viability after 48 hrs by MTT assay
    Antiproliferative activity against human HL7702 cells assessed as reduction in cell viability after 48 hrs by MTT assay
    		[PMID: 30878833]
    L1210 IC50
    0.007 μM
    Compound: Colchicine
    Antiproliferative activity against mouse L1210 cells after 96 hrs by coulter counting method
    Antiproliferative activity against mouse L1210 cells after 96 hrs by coulter counting method
    		[PMID: 29471122]
    L1210 IC50
    0.01 μM
    Compound: 1, colch
    Antiproliferative activity against mouse L1210 cells after 48 to 96 hrs by coulter counter analysis
    Antiproliferative activity against mouse L1210 cells after 48 to 96 hrs by coulter counter analysis
    		[PMID: 24773591]
    L1210 IC50
    0.01 μM
    Compound: 5
    Antiproliferative activity against mouse L1210 cells measured after 96 hrs by Coulter counter method
    Antiproliferative activity against mouse L1210 cells measured after 96 hrs by Coulter counter method
    		[PMID: 30921759]
    L1210 IC50
    0.014 μM
    Compound: Colchicine
    Antiproliferative activity against mouse L1210 assessed as inhibition of cell proliferation after 48 hrs by Coulter counter based cell counting method
    Antiproliferative activity against mouse L1210 assessed as inhibition of cell proliferation after 48 hrs by Coulter counter based cell counting method
    		[PMID: 25282265]
    L1210 IC50
    6.9 nM
    Compound: Col
    Antiproliferative activity against mouse L1210 after 48 hrs by SRB assay
    Antiproliferative activity against mouse L1210 after 48 hrs by SRB assay
    		[PMID: 21920638]
    L1210 IC50
    6.9 nM
    Compound: Col
    Antiproliferative activity against mouse L1210 cells after 48 hrs by sulforhodamine B assay
    Antiproliferative activity against mouse L1210 cells after 48 hrs by sulforhodamine B assay
    		[PMID: 21604746]
    L929 IC50
    1.01 μM
    Compound: 1
    Antiproliferative activity against mouse L929 cells after 72 hrs by MTT assay
    Antiproliferative activity against mouse L929 cells after 72 hrs by MTT assay
    		[PMID: 30245397]
    LCLC-103H cell line EC50
    0.07 μM
    Compound: Colchicine
    Antiproliferative activity against human LCLC-103H cells after 96 hrs by MTT assay
    Antiproliferative activity against human LCLC-103H cells after 96 hrs by MTT assay
    		[PMID: 29055869]
    LLC-PK1 IC50
    > 50 μM
    Compound: Colchicine
    Inhibition of P-glycoprotein, human L-MDR1 expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assay
    Inhibition of P-glycoprotein, human L-MDR1 expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assay
    		[PMID: 12699389]
    LLC-PK1 IC50
    > 50 μM
    Compound: Colchicine
    Inhibition of P-glycoprotein, mouse L-mdr1a expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assay
    Inhibition of P-glycoprotein, mouse L-mdr1a expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assay
    		[PMID: 12699389]
    LLC-PK1 IC50
    > 50 μM
    Compound: Colchicine
    Inhibition of P-glycoprotein, mouse L-mdr1b expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assay
    Inhibition of P-glycoprotein, mouse L-mdr1b expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assay
    		[PMID: 12699389]
    LNCaP IC50
    0.016 μM
    Compound: colchicine
    Cytotoxicity against human LNCAP cells after 48 hrs by SRB assay
    Cytotoxicity against human LNCAP cells after 48 hrs by SRB assay
    		[PMID: 19243174]
    LNCaP IC50
    0.02 μM
    Compound: Colchicine
    Antiproliferative activity against human LNCAP cells after 96 hrs by SRB assay
    Antiproliferative activity against human LNCAP cells after 96 hrs by SRB assay
    		[PMID: 22608389]
    LNCaP IC50
    0.02 μM
    Compound: Colchicine
    Antiproliferative activity against human LNCAP cells after 96 hrs by sulforhodamine B assay
    Antiproliferative activity against human LNCAP cells after 96 hrs by sulforhodamine B assay
    		[PMID: 21775150]
    LNCaP ED50
    0.06 μg/mL
    Compound: Colchicine
    Cytotoxicity against human LNCAP cells after 3 days by SRB assay
    Cytotoxicity against human LNCAP cells after 3 days by SRB assay
    		[PMID: 7528785]
    LNCaP IC50
    16 nM
    Compound: Colchicine
    Cytotoxicity against human LNCAP cells after 48 hrs by sulforhodamine B assay
    Cytotoxicity against human LNCAP cells after 48 hrs by sulforhodamine B assay
    		[PMID: 20919720]
    LNCaP IC50
    16.3 nM
    Compound: Colchicine
    Antiproliferative activity against human LNCAP cells after 48 hrs by SRB assay
    Antiproliferative activity against human LNCAP cells after 48 hrs by SRB assay
    		[PMID: 22783954]
    LoVo IC50
    0.054 μM
    Compound: 1
    Antiproliferative activity against human LoVo cells incubated for 72 hrs by sulforhodamine B assay
    Antiproliferative activity against human LoVo cells incubated for 72 hrs by sulforhodamine B assay
    		[PMID: 32432867]
    LoVo IC50
    0.101 μM
    Compound: Colchicine
    Cytotoxicity against human LoVo cells after 72 hrs by MTT assay
    Cytotoxicity against human LoVo cells after 72 hrs by MTT assay
    		[PMID: 21536450]
    LoVo IC50
    108 nM
    Compound: 1
    Antiproliferative activity against human LoVo cells incubated for 72 hrs by SRB assay
    Antiproliferative activity against human LoVo cells incubated for 72 hrs by SRB assay
    		[PMID: 33465696]
    LoVo IC50
    108.4 nM
    Compound: 1
    Antiproliferative activity against human LoVo cells assessed as reduction in cell viability incubated for 120 hrs by MTT assay
    Antiproliferative activity against human LoVo cells assessed as reduction in cell viability incubated for 120 hrs by MTT assay
    		[PMID: 31653441]
    LoVo IC50
    119 nM
    Compound: 1
    Cytotoxicity against human LoVo cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay
    Cytotoxicity against human LoVo cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay
    		[PMID: 30429975]
    LoVo IC50
    12.7 nM
    Compound: COLCH
    Antiproliferative activity against human LoVo cells assessed as inhibition of cell proliferation incubated for 72 hrs by SRB assay
    Antiproliferative activity against human LoVo cells assessed as inhibition of cell proliferation incubated for 72 hrs by SRB assay
    		[PMID: 34592435]
    LoVo IC50
    9.7 nM
    Compound: 1
    Antiproliferative activity against human LoVo cells assessed as inhibition of proliferation after 72 hrs by SRB assay
    Antiproliferative activity against human LoVo cells assessed as inhibition of proliferation after 72 hrs by SRB assay
    		[PMID: 34116158]
    LoVo IC50
    9.9 nM
    Compound: 1
    Antiproliferative activity against human LoVo cells assessed as inhibition of cell growth measured after 72 hrs by SRB assay
    Antiproliferative activity against human LoVo cells assessed as inhibition of cell growth measured after 72 hrs by SRB assay
    		[PMID: 33611191]
    Lu1 ED50
    0.2 μg/mL
    Compound: Colchicine
    Cytotoxicity against human Lu1 cells after 3 days by SRB assay
    Cytotoxicity against human Lu1 cells after 3 days by SRB assay
    		[PMID: 7528785]
    M14 IC50
    > 1 μM
    Compound: Colchicine
    Cytotoxicity against paclitaxel resistant human M14 cells measured after 72 hrs by western blot
    Cytotoxicity against paclitaxel resistant human M14 cells measured after 72 hrs by western blot
    		[PMID: 34378386]
    M14 IC50
    10.6 nM
    Compound: Colchicine
    Cytotoxicity against human M14 cells measured after 72 hrs by western blot
    Cytotoxicity against human M14 cells measured after 72 hrs by western blot
    		[PMID: 34378386]
    M14 IC50
    13.7 nM
    Compound: Colchicine
    Antiproliferative activity against human M14 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTS assay
    Antiproliferative activity against human M14 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTS assay
    		[PMID: 34406768]
    M14 IC50
    16.6 nM
    Compound: Colchicine
    Antiproliferative activity against human M14 cells after 72 hrs by MTT assay
    Antiproliferative activity against human M14 cells after 72 hrs by MTT assay
    		[PMID: 31251599]
    M14 IC50
    6.5 nM
    Compound: Colchicine
    Cytotoxicity against human M14 cells after 72 hrs by MTS assay
    Cytotoxicity against human M14 cells after 72 hrs by MTS assay
    		[PMID: 29406710]
    M14 IC50
    9.3 nM
    Compound: Colchicine
    Antiproliferative activity against human M14 cells measured after 72 hrs by MTS assay
    Antiproliferative activity against human M14 cells measured after 72 hrs by MTS assay
    		[PMID: 31860298]
    M21 GI50
    0.015 μM
    Compound: COL
    Antiproliferative activity against human M21 cells after 48 hrs by sulforhodamine B method
    Antiproliferative activity against human M21 cells after 48 hrs by sulforhodamine B method
    		[PMID: 18617414]
    M21 GI50
    0.015 μM
    Compound: colchicine
    Growth inhibition of human M21 cells after 48 hrs by sulforhodamine B assay
    Growth inhibition of human M21 cells after 48 hrs by sulforhodamine B assay
    		[PMID: 18579387]
    M21 GI50
    0.015 μM
    Compound: colchicine
    Growth inhibition of human M21 cells after 48 hrs
    Growth inhibition of human M21 cells after 48 hrs
    		[PMID: 17498960]
    MCF-10A IC50
    0.006 μM
    Compound: Colchicine
    Cytotoxicity against human MCF-10A cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
    Cytotoxicity against human MCF-10A cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
    		[PMID: 34670362]
    MCF7 GI50
    < 0.05 μM
    Compound: colchicine
    Compound was evaluated for growth inhibition against MCF-7 cells using cellular assay
    Compound was evaluated for growth inhibition against MCF-7 cells using cellular assay
    		[PMID: 9871709]
    MCF7 ED50
    > 0.4 μg/mL
    Compound: colchicine
    Cytotoxicity against human breast cancer cells (MCF-7) using SRB assay.
    Cytotoxicity against human breast cancer cells (MCF-7) using SRB assay.
    		[PMID: 9544215]
    MCF7 IC50
    > 300 nM
    Compound: 1; (-)-Colchicine
    Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 24 hrs by SRB assay
    Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 24 hrs by SRB assay
    		[PMID: 31655432]
    MCF7 IC50
    0.006 μM
    Compound: Colchicine
    Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
    		[PMID: 36511661]
    MCF7 GI50
    0.009 μM
    Compound: COL
    Antiproliferative activity against human MCF7 cells after 48 hrs by sulforhodamine B method
    Antiproliferative activity against human MCF7 cells after 48 hrs by sulforhodamine B method
    		[PMID: 18617414]
    MCF7 GI50
    0.009 μM
    Compound: colchicine
    Growth inhibition of human MCF7 cells after 48 hrs by sulforhodamine B assay
    Growth inhibition of human MCF7 cells after 48 hrs by sulforhodamine B assay
    		[PMID: 18579387]
    MCF7 GI50
    0.009 μM
    Compound: colchicine
    Growth inhibition of human MCF7 cells after 48 hrs
    Growth inhibition of human MCF7 cells after 48 hrs
    		[PMID: 17498960]
    MCF7 IC50
    0.012 μM
    Compound: colchicine
    Cytotoxicity against human MCF7 cells after 3 days by MTT assay
    Cytotoxicity against human MCF7 cells after 3 days by MTT assay
    		[PMID: 25426924]
    MCF7 IC50
    0.012 μM
    Compound: Colchicine
    Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
    		[PMID: 28863359]
    MCF7 IC50
    0.013 μM
    Compound: Colchicine
    Cytotoxicity against human MCF7 cells by SRB assay
    Cytotoxicity against human MCF7 cells by SRB assay
    		[PMID: 23220647]
    MCF7 IC50
    0.0134 μM
    Compound: Colchicine
    Antiproliferative activity against human MCF7 cells after 72 hrs by crystal violet biomass reduction assay
    Antiproliferative activity against human MCF7 cells after 72 hrs by crystal violet biomass reduction assay
    		[PMID: 20334421]
    MCF7 EC50
    0.016 μM
    Compound: 1
    Cytotoxicity against human MCF7 after 3 days by SRB assay
    Cytotoxicity against human MCF7 after 3 days by SRB assay
    		[PMID: 15730238]
    MCF7 IC50
    0.017 μM
    Compound: Colchicine
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    		[PMID: 21036623]
    MCF7 IC50
    0.017 μM
    Compound: colchicine
    Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
    Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
    		[PMID: 20493717]
    MCF7 IC50
    0.017 μM
    Compound: Colchicine
    Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay
    Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay
    		[PMID: 23602523]
    MCF7 IC50
    0.018 μM
    Compound: Colchicine
    Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK-8 assay
    Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK-8 assay
    		[PMID: 32650183]
    MCF7 IC50
    0.018 μM
    Compound: Colchicine
    Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
    		[PMID: 34571171]
    MCF7 IC50
    0.019 μM
    Compound: Colchicine
    Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay
    Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay
    		[PMID: 23932339]
    MCF7 IC50
    0.021 μM
    Compound: Colchicine
    Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
    		[PMID: 33788562]
    MCF7 IC50
    0.028 μM
    Compound: Colchicine
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    		[PMID: 34968813]
    MCF7 IC50
    0.04 μM
    Compound: Col
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    		[PMID: 34311158]
    MCF7 IC50
    0.043 μM
    Compound: Colchicine
    Antiproliferative activity against human MCF7 cells over expressing GLUT1 measured after 72 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells over expressing GLUT1 measured after 72 hrs by MTT assay
    		[PMID: 35193066]
    MCF7 IC50
    0.047 μM
    Compound: 1
    Growth inhibition of human MCF7 cells incubated for 72 hrs by MTT assay
    Growth inhibition of human MCF7 cells incubated for 72 hrs by MTT assay
    		[PMID: 27172319]
    MCF7 IC50
    0.048 μM
    Compound: Colchicine
    Antiproliferative activity against human MCF7 assessed as reduction in cell viability measured after 48 hrs by MTT assay
    Antiproliferative activity against human MCF7 assessed as reduction in cell viability measured after 48 hrs by MTT assay
    		[PMID: 34175541]
    MCF7 IC50
    0.05 μM
    Compound: Colchicine
    Cytotoxicity in human MCF7 cells assessed as growth inhibition level after 48 hrs by SRB assay
    Cytotoxicity in human MCF7 cells assessed as growth inhibition level after 48 hrs by SRB assay
    		[PMID: 36162138]
    MCF7 IC50
    0.05 μM
    Compound: Colchicine
    Cytotoxicity against vinblastine-sensitive human MCF7 cells assessed as growth inhibition after 72 hrs by SRB assay
    Cytotoxicity against vinblastine-sensitive human MCF7 cells assessed as growth inhibition after 72 hrs by SRB assay
    		[PMID: 28006904]
    MCF7 IC50
    0.054 μM
    Compound: 1
    Antiproliferative activity against human MCF7 cells incubated for 72 hrs by sulforhodamine B assay
    Antiproliferative activity against human MCF7 cells incubated for 72 hrs by sulforhodamine B assay
    		[PMID: 32432867]
    MCF7 IC50
    0.06 μM
    Compound: 2
    Cytotoxicity against human MCF7 cells after 68 hrs by MTT assay
    Cytotoxicity against human MCF7 cells after 68 hrs by MTT assay
    		[PMID: 32243160]
    MCF7 EC50
    0.061 μM
    Compound: Colchicine
    Antiproliferative activity against human MCF7 cells after 96 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells after 96 hrs by MTT assay
    		[PMID: 29055869]
    MCF7 IC50
    0.07 μM
    Compound: Colchicine
    Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
    Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
    		[PMID: 25499929]
    MCF7 IC50
    0.072 μM
    Compound: Colchicine
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    		[PMID: 27608432]
    MCF7 IC50
    0.11 μM
    Compound: Colchicine
    Antiproliferative activity against human MCF7 cells incubated for 48 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells incubated for 48 hrs by MTT assay
    		[PMID: 32035399]
    MCF7 IC50
    0.1504 μM
    Compound: Colchicine
    Antiproliferative activity against human MCF7 cells after 48 hrs by SRB assay
    Antiproliferative activity against human MCF7 cells after 48 hrs by SRB assay
    		[PMID: 27744186]
    MCF7 IC50
    0.16 μM
    Compound: Colchicine
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
    		[PMID: 35447432]
    MCF7 IC50
    0.16 μM
    Compound: COL
    Antiproliferative activity against human MCF7 cells after 48 hrs by SRB method
    Antiproliferative activity against human MCF7 cells after 48 hrs by SRB method
    		[PMID: 25061803]
    MCF7 IC50
    0.22 μM
    Compound: Colchicine
    Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 24 hrs in presence of foetal bovine serum by MTT assay
    Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 24 hrs in presence of foetal bovine serum by MTT assay
    		[PMID: 35367708]
    MCF7 IC50
    0.29 μM
    Compound: Colchicine
    Cytotoxicity against human MCF7 cells by MTT assay
    Cytotoxicity against human MCF7 cells by MTT assay
    		[PMID: 23425970]
    MCF7 IC50
    0.33 μg/mL
    Compound: Colchicine
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    		[PMID: 30389289]
    MCF7 IC50
    0.39 μg/mL
    Compound: 1
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    		[PMID: 24916028]
    MCF7 IC50
    0.39 μM
    Compound: Colchicine
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    		[PMID: 25703297]
    MCF7 GI50
    0.4 μM
    Compound: Colchicine
    Antiproliferative activity against human MCF7 cells assessed as growth inhibition after 72 hrs by sulforhodamine B assay
    Antiproliferative activity against human MCF7 cells assessed as growth inhibition after 72 hrs by sulforhodamine B assay
    		[PMID: 30288225]
    MCF7 IC50
    0.41 μM
    Compound: Col
    Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation incubated for 24 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation incubated for 24 hrs by MTT assay
    		[PMID: 36760739]
    MCF7 IC50
    0.44 μM
    Compound: Colchicine
    Antiproliferative activity against human MCF7 cells after 24 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells after 24 hrs by MTT assay
    		[PMID: 30606674]
    MCF7 IC50
    0.51 μg/mL
    Compound: Colchicine
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    		[PMID: 22503741]
    MCF7 IC50
    0.52 μM
    Compound: Colchicine
    Antiproliferative activity against drug-resistant human MCF7 cells incubated for 48 hrs by MTT assay
    Antiproliferative activity against drug-resistant human MCF7 cells incubated for 48 hrs by MTT assay
    		[PMID: 32035399]
    MCF7 IC50
    0.53 μg/mL
    Compound: Colchicine
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    		[PMID: 22261027]
    MCF7 IC50
    0.53 μM
    Compound: Colchicine
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    		[PMID: 22512906]
    MCF7 IC50
    0.54 μM
    Compound: Colchicine
    Antiproliferative activity against human MCF7 cells measured after 24 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells measured after 24 hrs by MTT assay
    		10.1039/C6MD00255B
    MCF7 IC50
    1.9 μM
    Compound: Colchicin
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    		[PMID: 21576023]
    MCF7 IC50
    10.1 nM
    Compound: COLCH
    Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation incubated for 72 hrs by SRB assay
    Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation incubated for 72 hrs by SRB assay
    		[PMID: 34592435]
    MCF7 IC50
    10.9 nM
    Compound: 1
    Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth measured after 72 hrs by SRB assay
    Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth measured after 72 hrs by SRB assay
    		[PMID: 33611191]
    MCF7 IC50
    12 nM
    Compound: 1
    Cytotoxicity against human MCF7 cells after 72 hrs by crystal violet staining
    Cytotoxicity against human MCF7 cells after 72 hrs by crystal violet staining
    		[PMID: 20529690]
    MCF7 IC50
    12 nM
    Compound: Colchicine
    Antiproliferative activity against human MCF7 cells after 2 days by MTT assay
    Antiproliferative activity against human MCF7 cells after 2 days by MTT assay
    		[PMID: 29550732]
    MCF7 IC50
    12 nM
    Compound: Colchicine
    Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTT assay
    Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTT assay
    		[PMID: 27915168]
    MCF7 IC50
    12000 nM
    Compound: 1
    Anti tumor activity on human breast cancer cell line MDR-positive MCF-7 ADRr after 72 hours of treatment
    Anti tumor activity on human breast cancer cell line MDR-positive MCF-7 ADRr after 72 hours of treatment
    		[PMID: 10602712]
    MCF7 IC50
    13 nM
    Compound: 1
    Antiproliferative activity against human MCF-7 cells assessed as inhibition of proliferation after 72 hrs by SRB assay
    Antiproliferative activity against human MCF-7 cells assessed as inhibition of proliferation after 72 hrs by SRB assay
    		[PMID: 34116158]
    MCF7 IC50
    13 nM
    Compound: 1
    Growth inhibition of human MCF7 cells after 48 hrs
    Growth inhibition of human MCF7 cells after 48 hrs
    		[PMID: 17497841]
    MCF7 IC50
    13 nM
    Compound: colchicine
    Growth inhibition of human MCF7 cells assessed as G2/M DNA content after 48 hrs
    Growth inhibition of human MCF7 cells assessed as G2/M DNA content after 48 hrs
    		[PMID: 15566282]
    MCF7 IC50
    13.4 nM
    Compound: Colchicine
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    		[PMID: 28763646]
    MCF7 GI50
    13.5 μM
    Compound: Colchicine
    Growth inhibition of human MCF7 cells assessed as inhibition of cell proliferation after 24 hrs by MTT assay
    Growth inhibition of human MCF7 cells assessed as inhibition of cell proliferation after 24 hrs by MTT assay
    		[PMID: 26070164]
    MCF7 IC50
    14.3 μM
    Compound: Colchicine
    Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTT assay
    		[PMID: 30878833]
    MCF7 IC50
    2.8 μM
    Compound: Colchicine
    Cytotoxicity against multidrug resistant human MCF7 cells cultured in vinblastine free medium assessed as growth inhibition after 72 hrs by SRB assay
    Cytotoxicity against multidrug resistant human MCF7 cells cultured in vinblastine free medium assessed as growth inhibition after 72 hrs by SRB assay
    		[PMID: 28006904]
    MCF7 IC50
    2.8 μM
    Compound: Colchicine
    Cytotoxicity against multidrug resistant human MCF7 cells cultured in vinblastine containing medium assessed as growth inhibition after 72 hrs by SRB assay
    Cytotoxicity against multidrug resistant human MCF7 cells cultured in vinblastine containing medium assessed as growth inhibition after 72 hrs by SRB assay
    		[PMID: 28006904]
    MCF7 IC50
    20 nM
    Compound: Colchicine
    Antiproliferative activity against human MCF7 cells after 2 days by MTT assay
    Antiproliferative activity against human MCF7 cells after 2 days by MTT assay
    		[PMID: 29604583]
    MCF7 IC50
    20.7 nM
    Compound: 1
    Antiproliferative activity against human MCF-7 cells incubated for 72 hrs by SRB assay
    Antiproliferative activity against human MCF-7 cells incubated for 72 hrs by SRB assay
    		[PMID: 33465696]
    MCF7 IC50
    24.98 μM
    Compound: Colchicine
    Cytotoxicity against human MCF7 cells treated for 72 hrs by MTT assay
    Cytotoxicity against human MCF7 cells treated for 72 hrs by MTT assay
    		[PMID: 35344904]
    MCF7 IC50
    3.2 μM
    Compound: COL
    Antiproliferative activity against doxorubicin-resistant human MCF7 cells after 48 hrs by SRB method
    Antiproliferative activity against doxorubicin-resistant human MCF7 cells after 48 hrs by SRB method
    		[PMID: 25061803]
    MCF7 IC50
    38 nM
    Compound: Colchicine
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    		[PMID: 33234343]
    MCF7 IC50
    41 nM
    Compound: 1
    Cytotoxicity against human MCF7 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay
    Cytotoxicity against human MCF7 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay
    		[PMID: 30429975]
    MCF7 IC50
    5 nM
    Compound: Colchicine
    Cytotoxicity against human MCF7 cells assessed as reduction in cell growth incubated for 96 hrs by MTT assay
    Cytotoxicity against human MCF7 cells assessed as reduction in cell growth incubated for 96 hrs by MTT assay
    		[PMID: 31727471]
    MCF7 IC50
    5 nM
    Compound: 1
    Cytotoxicity against human MCF7 cells assessed as growth inhibition after 48 hrs by SRB assay
    Cytotoxicity against human MCF7 cells assessed as growth inhibition after 48 hrs by SRB assay
    		[PMID: 26132075]
    MCF7 IC50
    5 nM
    Compound: Colch
    Cytotoxicity against human MCF7 cells assessed as cell growth inhibition incubated for 3 days by trypan blue exclusion assay
    Cytotoxicity against human MCF7 cells assessed as cell growth inhibition incubated for 3 days by trypan blue exclusion assay
    		[PMID: 28523104]
    MCF7 IC50
    5 nM
    Compound: Colchicine
    Growth inhibition of human MCF7 cells after 96 hrs by trypan blue exclusion assay
    Growth inhibition of human MCF7 cells after 96 hrs by trypan blue exclusion assay
    		[PMID: 29730191]
    MCF7 IC50
    5 nM
    Compound: 1
    Cytotoxicity against human MCF7 cells assessed as growth inhibition by trypan blue exclusion assay
    Cytotoxicity against human MCF7 cells assessed as growth inhibition by trypan blue exclusion assay
    		[PMID: 23214452]
    MCF7 IC50
    5 nM
    Compound: 1
    Cytotoxicity against human MCF7 cells after 96 hrs by Giemsa staining-based light microscopy
    Cytotoxicity against human MCF7 cells after 96 hrs by Giemsa staining-based light microscopy
    		[PMID: 25025991]
    MCF7 IC50
    5 nM
    Compound: 1
    Growth inhibition of human MCF7 cells after 96 hrs
    Growth inhibition of human MCF7 cells after 96 hrs
    		[PMID: 22044164]
    MCF7 IC50
    5.19 μM
    Compound: COL
    Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
    		[PMID: 35694693]
    MCF7 IC50
    54.3 nM
    Compound: 1
    Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 120 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 120 hrs by MTT assay
    		[PMID: 31653441]
    MCF7 IC50
    58 nM
    Compound: colchicine
    Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay
    		[PMID: 25208345]
    MCF7 IC50
    64 nM
    Compound: Colchicine
    Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
    		[PMID: 35084853]
    MCF7 IC50
    64.1 nM
    Compound: 1
    Antiproliferative activity against human MCF7 cells after 24 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells after 24 hrs by MTT assay
    		[PMID: 27213819]
    MCF7-VP IC50
    1.57 μM
    Compound: Colchicine
    Cytotoxicity in human MCF7/Vin cells assessed as growth inhibition level after 48 hrs by SRB assay
    Cytotoxicity in human MCF7/Vin cells assessed as growth inhibition level after 48 hrs by SRB assay
    		[PMID: 36162138]
    MDA-MB-231 GI50
    < 0.01 μM
    Compound: Colchicine
    Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by SRB assay
    Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by SRB assay
    		[PMID: 25827522]
    MDA-MB-231 IC50
    0.008 μM
    Compound: Colchicine
    Antiproliferative activity against human MDA-MB-231 cells by MTS assay
    Antiproliferative activity against human MDA-MB-231 cells by MTS assay
    		10.1039/C3MD00077J
    MDA-MB-231 IC50
    0.023 μM
    Compound: Colchicine
    Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
    Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
    		[PMID: 36511661]
    MDA-MB-231 IC50
    0.03 μM
    Compound: colchicine
    Antiproliferative activity against human MDA-MB-231 cells after 4 days by microplate assay
    Antiproliferative activity against human MDA-MB-231 cells after 4 days by microplate assay
    		[PMID: 17889547]
    MDA-MB-231 IC50
    0.07 μM
    Compound: 1, colchicine
    Antiproliferative activity against human MDA-MB-231 cells after 72 hrs
    Antiproliferative activity against human MDA-MB-231 cells after 72 hrs
    		[PMID: 18503262]
    MDA-MB-231 IC50
    0.097 μM
    Compound: Colchicine
    Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
    Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
    		[PMID: 35447432]
    MDA-MB-231 IC50
    0.176 μM
    Compound: Colchicine
    Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
    Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
    		[PMID: 36455508]
    MDA-MB-231 IC50
    0.93 μM
    Compound: Colchicine
    Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation measured after 48 hrs by MTT assay
    Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation measured after 48 hrs by MTT assay
    		[PMID: 32768647]
    MDA-MB-231 GI50
    1.5 μM
    Compound: Colchicine
    Antiproliferative activity against human MDA-MB-231 cells assessed as growth inhibition after 72 hrs by sulforhodamine B assay
    Antiproliferative activity against human MDA-MB-231 cells assessed as growth inhibition after 72 hrs by sulforhodamine B assay
    		[PMID: 30288225]
    MDA-MB-231 IC50
    1.8 nM
    Compound: 1
    Anti tumor activity on human breast cancer cell line MDR-negative MDA-MB 231 after 72 hours of treatment
    Anti tumor activity on human breast cancer cell line MDR-negative MDA-MB 231 after 72 hours of treatment
    		[PMID: 10602712]
    MDA-MB-231 IC50
    1.98 μM
    Compound: Colchicine
    Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
    Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
    		[PMID: 37122544]
    MDA-MB-231 IC50
    17.5 nM
    Compound: Colchicine
    Antiproliferative activity against human MDA-MB-231 cells incubated for 72 hrs by MTT assay
    Antiproliferative activity against human MDA-MB-231 cells incubated for 72 hrs by MTT assay
    		[PMID: 34648295]
    MDA-MB-231 IC50
    2 μM
    Compound: Colchicine
    Antiproliferative activity against human MDA-MB-231 cells by SRB assay
    Antiproliferative activity against human MDA-MB-231 cells by SRB assay
    		[PMID: 30119011]
    MDA-MB-231 IC50
    2.75 μM
    Compound: Colchi
    Antimigratory activity in human MDA-MB-231 cells assessed as inhibition of cell motility after 24 hrs by microscopic analysis
    Antimigratory activity in human MDA-MB-231 cells assessed as inhibition of cell motility after 24 hrs by microscopic analysis
    		[PMID: 31838326]
    MDA-MB-231 IC50
    2.9 nM
    Compound: Col
    Antiproliferative activity against human MDA-MB-231 after 48 hrs by SRB assay
    Antiproliferative activity against human MDA-MB-231 after 48 hrs by SRB assay
    		[PMID: 21920638]
    MDA-MB-231 IC50
    2.9 nM
    Compound: Col
    Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by sulforhodamine B assay
    Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by sulforhodamine B assay
    		[PMID: 21604746]
    MDA-MB-231 IC50
    2.94 μM
    Compound: Colchicine
    Antiproliferative activity against human MDA-MB-231 cells incubated for 48 hrs by MTT assay
    Antiproliferative activity against human MDA-MB-231 cells incubated for 48 hrs by MTT assay
    		[PMID: 32035399]
    MDA-MB-231 IC50
    20 nM
    Compound: colchichine
    Cytotoxicity against human MDA-MB-231 cells after 48 hrs by alamar blue assay
    Cytotoxicity against human MDA-MB-231 cells after 48 hrs by alamar blue assay
    		[PMID: 19117761]
    MDA-MB-231 IC50
    22.4 nM
    Compound: Colchicine
    Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTS assay
    Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTS assay
    		[PMID: 34406768]
    MDA-MB-231 IC50
    24.3 nM
    Compound: Colchicine
    Cytotoxicity against human MDA-MB-231 cells measured after 72 hrs by western blot
    Cytotoxicity against human MDA-MB-231 cells measured after 72 hrs by western blot
    		[PMID: 34378386]
    MDA-MB-231 IC50
    25 nM
    Compound: 1
    Cytotoxicity against human MDA-MB-231 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay
    Cytotoxicity against human MDA-MB-231 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay
    		[PMID: 30429975]
    MDA-MB-231 IC50
    26 nM
    Compound: colchicine
    Cytotoxicity against human MDA-MB-231 cells after 72 hrs
    Cytotoxicity against human MDA-MB-231 cells after 72 hrs
    		[PMID: 19530698]
    MDA-MB-231 IC50
    3.55 μM
    Compound: Colchicine
    Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay
    Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay
    		[PMID: 27608432]
    MDA-MB-231 IC50
    3.89 μM
    Compound: Colchicine
    Antiproliferative activity against human MDA231 cells after 24 hrs by MTT assay
    Antiproliferative activity against human MDA231 cells after 24 hrs by MTT assay
    		[PMID: 29268130]
    MDA-MB-231 IC50
    37 nM
    Compound: colchicine
    Cytotoxicity against human MDA-MB-231 cells after 96 hrs by MTT assay
    Cytotoxicity against human MDA-MB-231 cells after 96 hrs by MTT assay
    		[PMID: 23176628]
    MDA-MB-231 IC50
    38.2 nM
    Compound: Colchicine
    Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay
    Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay
    		[PMID: 28763646]
    MDA-MB-231 IC50
    475 nM
    Compound: 1a
    Antimigratory activity against human MDA-MB-231 cells after 6 hrs by Boyden chamber migration assay
    Antimigratory activity against human MDA-MB-231 cells after 6 hrs by Boyden chamber migration assay
    		[PMID: 23524161]
    MDA-MB-231 IC50
    7.07 μM
    Compound: Colchicine
    Antimigratory activity against Homo sapiens (human) MDA-MB-231 cells after 24 to 48 hr by microscopic analysis
    Antimigratory activity against Homo sapiens (human) MDA-MB-231 cells after 24 to 48 hr by microscopic analysis
    		10.1007/s00044-012-0428-9
    MDA-MB-231 IC50
    77.62 nM
    Compound: Colchicine
    Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay
    Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay
    		[PMID: 30197030]
    MDA-MB-435 IC50
    0.0073 μM
    Compound: Colchicine
    Cytotoxicity against human MDA-MB-435 cells after 72 hrs by MTT assay
    Cytotoxicity against human MDA-MB-435 cells after 72 hrs by MTT assay
    		[PMID: 21536450]
    MDA-MB-435 IC50
    0.016 μM
    Compound: colchicine
    Antiproliferative activity against human MDA-MB-435 cells by sulforhodamine B assay
    Antiproliferative activity against human MDA-MB-435 cells by sulforhodamine B assay
    		[PMID: 22611477]
    MDA-MB-435 IC50
    0.04 μM
    Compound: 1, colchicine
    Antiproliferative activity against human MDA-MB-435 cells after 72 hrs
    Antiproliferative activity against human MDA-MB-435 cells after 72 hrs
    		[PMID: 18503262]
    MDA-MB-435 IC50
    11 nM
    Compound: Colchicine
    Cytotoxicity against human MDA-MB-435 cells assessed as growth inhibition after 48 hrs by SRB assay
    Cytotoxicity against human MDA-MB-435 cells assessed as growth inhibition after 48 hrs by SRB assay
    		[PMID: 23547728]
    MDA-MB-435 IC50
    2 μM
    Compound: colchicine
    Antiproliferative activity against human MDA-MB-435 cells after 48 hrs by SRB assay
    Antiproliferative activity against human MDA-MB-435 cells after 48 hrs by SRB assay
    		[PMID: 18083520]
    MDA-MB-435 IC50
    658 nM
    Compound: Colchicine
    Cytotoxicity against human MDA-MB-435 cells after 48 hrs by sulforhodamine B assay
    Cytotoxicity against human MDA-MB-435 cells after 48 hrs by sulforhodamine B assay
    		[PMID: 20919720]
    MDA-MB-435S IC50
    0.007 μM
    Compound: Colchicine
    Cytotoxicity against human MDA-MB-435S cells assessed as growth inhibition after 72 hrs by CCK-8 assay
    Cytotoxicity against human MDA-MB-435S cells assessed as growth inhibition after 72 hrs by CCK-8 assay
    		[PMID: 25091926]
    MDA-MB-453 IC50
    5.8 nM
    Compound: Colchicine
    Antiproliferative activity against human MDA-MB-453 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTS assay
    Antiproliferative activity against human MDA-MB-453 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTS assay
    		[PMID: 34406768]
    MDA-MB-468 IC50
    0.06 μM
    Compound: Colchicine
    Antiproliferative activity against human MDA-MB-468 cells by SRB assay
    Antiproliferative activity against human MDA-MB-468 cells by SRB assay
    		[PMID: 28988750]
    MDA-MB-468 IC50
    2.1 nM
    Compound: 1
    Cytotoxicity against human MDA-MB-468 cells assessed as cell viability after 4 days by MTS assay
    Cytotoxicity against human MDA-MB-468 cells assessed as cell viability after 4 days by MTS assay
    		[PMID: 24210503]
    MDA-MB-468 IC50
    9.9 nM
    Compound: Colchicine
    Antiproliferative activity against human MDA-MB-468 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTS assay
    Antiproliferative activity against human MDA-MB-468 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTS assay
    		[PMID: 34406768]
    MES-SA IC50
    11 nM
    Compound: 1
    Cytotoxicity against human MESSA cells assessed as growth inhibition after 72 hrs by CellTiter-Glo assay
    Cytotoxicity against human MESSA cells assessed as growth inhibition after 72 hrs by CellTiter-Glo assay
    		[PMID: 26132075]
    MES-SA IC50
    11 nM
    Compound: 1
    Cytotoxicity against human MESSA cells assessed as growth inhibition after 72 hrs by Celltiter-Glo luminescent assay
    Cytotoxicity against human MESSA cells assessed as growth inhibition after 72 hrs by Celltiter-Glo luminescent assay
    		[PMID: 23214452]
    MES-SA IC50
    11 nM
    Compound: 1
    Cytotoxicity against human MESSA cells assessed as growth inhibition after 72 hrs by CellTitre-Glo assay
    Cytotoxicity against human MESSA cells assessed as growth inhibition after 72 hrs by CellTitre-Glo assay
    		[PMID: 25025991]
    MES-SA IC50
    15 nM
    Compound: Colchicine
    Antiproliferative activity against human MES-SA cells after 72 hrs by resazurin assay
    Antiproliferative activity against human MES-SA cells after 72 hrs by resazurin assay
    		[PMID: 26602281]
    MES-SA IC50
    6.3 nM
    Compound: colchicine
    Antiproliferative activity against drug sensitive Messa cell line by Alamar Blue assay
    Antiproliferative activity against drug sensitive Messa cell line by Alamar Blue assay
    		[PMID: 17286393]
    MES-SA/Dx5 IC50
    329 nM
    Compound: 1
    Cytotoxicity against human MESSA/DX5 cells assessed as growth inhibition after 72 hrs by CellTiter-Glo assay
    Cytotoxicity against human MESSA/DX5 cells assessed as growth inhibition after 72 hrs by CellTiter-Glo assay
    		[PMID: 26132075]
    MES-SA/Dx5 IC50
    329 nM
    Compound: 1
    Cytotoxicity against human MESSA/DX5 cells assessed as growth inhibition after 72 hrs by Celltiter-Glo luminescent assay
    Cytotoxicity against human MESSA/DX5 cells assessed as growth inhibition after 72 hrs by Celltiter-Glo luminescent assay
    		[PMID: 23214452]
    MES-SA/Dx5 IC50
    329 nM
    Compound: 1
    Cytotoxicity against human MESSA/DX5 cells assessed as growth inhibition after 72 hrs by CellTitre-Glo assay
    Cytotoxicity against human MESSA/DX5 cells assessed as growth inhibition after 72 hrs by CellTitre-Glo assay
    		[PMID: 25025991]
    MES-SA/Dx5 IC50
    63 nM
    Compound: colchicine
    Antiproliferative activity against drug resistant Messa/DX5 cell line expressing MDR1 by Alamar Blue assay
    Antiproliferative activity against drug resistant Messa/DX5 cell line expressing MDR1 by Alamar Blue assay
    		[PMID: 17286393]
    MES-SA/Dx5 IC50
    757 nM
    Compound: Colchicine
    Antiproliferative activity against multidrug-resistant human MES-SA/Dx5 cells assessed as reduction in cell viability incubated for 72 hrs by prestoblue dye based assay
    Antiproliferative activity against multidrug-resistant human MES-SA/Dx5 cells assessed as reduction in cell viability incubated for 72 hrs by prestoblue dye based assay
    		[PMID: 33618157]
    MGC-803 IC50
    0.062 μM
    Compound: Colchicine
    Antiproliferative activity against human MGC-803 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
    Antiproliferative activity against human MGC-803 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
    		[PMID: 35834904]
    MGC-803 IC50
    0.062 μM
    Compound: Colchicine
    Antiproliferative activity against human MGC-803 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
    Antiproliferative activity against human MGC-803 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
    		[PMID: 35605363]
    MGC-803 IC50
    0.09 μM
    Compound: Colchicine
    Antiproliferative activity against human MGC-803 cells assessed as cell growth inhibition measured after 48 hrs by CCK8 assay
    Antiproliferative activity against human MGC-803 cells assessed as cell growth inhibition measured after 48 hrs by CCK8 assay
    		[PMID: 34971875]
    MGC-803 IC50
    0.107 μM
    Compound: Colchicine
    Antiproliferative activity against human MGC-803 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
    Antiproliferative activity against human MGC-803 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
    		[PMID: 32682200]
    MGC-803 IC50
    0.177 μM
    Compound: Colchicine
    Antiproliferative activity against human MGC803 cells after 48 hrs by MTT assay
    Antiproliferative activity against human MGC803 cells after 48 hrs by MTT assay
    		[PMID: 30075402]
    MGC-803 IC50
    0.27 μM
    Compound: Colchicine
    Antiproliferative activity against human MGC803 cells measured after 48 hrs by MTT assay
    Antiproliferative activity against human MGC803 cells measured after 48 hrs by MTT assay
    		[PMID: 30690300]
    MGC-803 IC50
    1.07 μM
    Compound: Colchicine
    Antiproliferative activity against human MGC-803 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK8 assay
    Antiproliferative activity against human MGC-803 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK8 assay
    		[PMID: 34022412]
    MGC-803 IC50
    1.07 μM
    Compound: Colchicine
    Antiproliferative activity against human MGC-803 cells incubated for 48 hrs by CCK8 assay
    Antiproliferative activity against human MGC-803 cells incubated for 48 hrs by CCK8 assay
    		[PMID: 33965530]
    MHCC97H IC50
    0.11 μM
    Compound: Colchicine
    Cytotoxicity against human MHCC97H cells assessed as growth inhibition after 72 hrs by MTT assay
    Cytotoxicity against human MHCC97H cells assessed as growth inhibition after 72 hrs by MTT assay
    		[PMID: 25805446]
    MIA PaCa-2 IC50
    0.042 μM
    Compound: 1
    Cytotoxicity against human Mia PaCa-2 cells incubated for 48 hrs by MTT assay
    Cytotoxicity against human Mia PaCa-2 cells incubated for 48 hrs by MTT assay
    		[PMID: 32432867]
    MIA PaCa-2 IC50
    1.3 nM
    Compound: 1
    Cytotoxic activity in human MIAPaCa2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
    Cytotoxic activity in human MIAPaCa2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
    		[PMID: 29028531]
    MIA PaCa-2 IC50
    160 nM
    Compound: 1
    Cytotoxicity against 2D culture of human MIAPaCa2 cells measured after 72 hrs by MTT assay
    Cytotoxicity against 2D culture of human MIAPaCa2 cells measured after 72 hrs by MTT assay
    		[PMID: 27912174]
    MIA PaCa-2 IC50
    25 nM
    Compound: colchichine
    Cytotoxicity against human MIAPaCa2 cells after 48 hrs by alamar blue assay
    Cytotoxicity against human MIAPaCa2 cells after 48 hrs by alamar blue assay
    		[PMID: 19117761]
    MIA PaCa-2 IC50
    6.1 nM
    Compound: Colchicine
    Antiproliferative activity against human MIA PaCa-2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
    Antiproliferative activity against human MIA PaCa-2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
    		[PMID: 33618157]
    MKN-45 IC50
    0.002 μM
    Compound: Colchicine
    Cytotoxicity against human MKN45 cells assessed as growth inhibition after 72 hrs by MTT assay
    Cytotoxicity against human MKN45 cells assessed as growth inhibition after 72 hrs by MTT assay
    		[PMID: 25805446]
    MKN-45 IC50
    11 nM
    Compound: 4
    Growth inhibition of human MKN45 cells after 72 hrs by methylene blue dye assay
    Growth inhibition of human MKN45 cells after 72 hrs by methylene blue dye assay
    		[PMID: 18588280]
    MKN-45 IC50
    11.5 nM
    Compound: 6
    Antiproliferative activity against human MKN45 cells assessed as inhibition of cell growth after 72 hrs by methylene blue dye assay
    Antiproliferative activity against human MKN45 cells assessed as inhibition of cell growth after 72 hrs by methylene blue dye assay
    		10.1039/C0MD00052C
    MKN-45 IC50
    11.5 nM
    Compound: 1
    Cytotoxicity against human MKN45 cells assessed as growth inhibition after 72 hrs by methylene blue staining-based assay
    Cytotoxicity against human MKN45 cells assessed as growth inhibition after 72 hrs by methylene blue staining-based assay
    		[PMID: 24106982]
    MKN-45 IC50
    12 nM
    Compound: 5
    Antiproliferative activity against human MKN45 cells after 72 hrs by methylene blue assay
    Antiproliferative activity against human MKN45 cells after 72 hrs by methylene blue assay
    		[PMID: 21641700]
    MKN-45 IC50
    12.4 nM
    Compound: 3
    Antiproliferative activity against human MKN45 cells after 72 hrs by methylene blue dye assay
    Antiproliferative activity against human MKN45 cells after 72 hrs by methylene blue dye assay
    		[PMID: 20148562]
    MKN-45 IC50
    13 nM
    Compound: 1
    Growth inhibition of human MKN45 cells after 72 hrs by methylene blue dye assay
    Growth inhibition of human MKN45 cells after 72 hrs by methylene blue dye assay
    		[PMID: 19053773]
    MKN-45 IC50
    13 nM
    Compound: colchichine
    Growth inhibition of human MKN45 cells after 72 hrs by methylene blue dye assay
    Growth inhibition of human MKN45 cells after 72 hrs by methylene blue dye assay
    		[PMID: 17685504]
    MKN-45 IC50
    14.9 nM
    Compound: Colchicine
    Antiproliferative activity against human MKN45 cells after 72 hrs by methylene blue assay
    Antiproliferative activity against human MKN45 cells after 72 hrs by methylene blue assay
    		[PMID: 26160020]
    MKN-45 IC50
    14.9 nM
    Compound: colchicine
    Cytotoxicity against human MKN45 cells after 72 hrs by methylene blue assay
    Cytotoxicity against human MKN45 cells after 72 hrs by methylene blue assay
    		[PMID: 24657567]
    MKN-45 IC50
    15 nM
    Compound: Colchicine
    Cytotoxicity against human MKN45 cell line by methylene blue dye assay
    Cytotoxicity against human MKN45 cell line by methylene blue dye assay
    		[PMID: 17154496]
    MKN-45 IC50
    19.2 nM
    Compound: 1
    Growth inhibition of human MKN45 cells after 72 hrs by methylene blue assay
    Growth inhibition of human MKN45 cells after 72 hrs by methylene blue assay
    		[PMID: 22060033]
    MOLM-13 IC50
    4.71 nM
    Compound: Colchicine
    Antiproliferative activity against human MOLM-13 cells incubated for 72 hrs by MTT assay
    Antiproliferative activity against human MOLM-13 cells incubated for 72 hrs by MTT assay
    		[PMID: 34648295]
    MRC5 IC50
    0.09 μM
    Compound: Colchicine
    Antiproliferative activity against human MRC5 cells by SRB assay
    Antiproliferative activity against human MRC5 cells by SRB assay
    		[PMID: 28988750]
    MRC5 IC50
    6.2 μM
    Compound: Colchicine
    Antiproliferative activity against human MRC5 cells assessed as reduction in cell viability after 48 hrs by MTT assay
    Antiproliferative activity against human MRC5 cells assessed as reduction in cell viability after 48 hrs by MTT assay
    		[PMID: 30878833]
    MV4-11 IC50
    1.58 nM
    Compound: Colchicine
    Antiproliferative activity against human MV4-11 cells incubated for 72 hrs by MTT assay
    Antiproliferative activity against human MV4-11 cells incubated for 72 hrs by MTT assay
    		[PMID: 34648295]
    NCI/ADR-RES IC50
    1113 nM
    Compound: Colchicine
    Anticancer activity against P-gp overexpressing human NCI/ADR-RES cells after 96 hrs by SRB assay
    Anticancer activity against P-gp overexpressing human NCI/ADR-RES cells after 96 hrs by SRB assay
    		[PMID: 21557538]
    NCI/ADR-RES IC50
    3.12 μM
    Compound: Colchicine
    Cytotoxicity against human MCF7/ADR cells by MTT assay
    Cytotoxicity against human MCF7/ADR cells by MTT assay
    		[PMID: 23425970]
    NCI/ADR-RES IC50
    420 nM
    Compound: 1
    Cytotoxicity against Pgp overexpressing human NCI-ADR-RES cells assessed as growth inhibition after 48 hrs by SRB assay
    Cytotoxicity against Pgp overexpressing human NCI-ADR-RES cells assessed as growth inhibition after 48 hrs by SRB assay
    		[PMID: 26132075]
    NCI/ADR-RES IC50
    420 nM
    Compound: 1
    Cytotoxicity against human NCI/ADR-RES cells assessed as growth inhibition after 96 hrs by Giemsa staining-based light microscopy
    Cytotoxicity against human NCI/ADR-RES cells assessed as growth inhibition after 96 hrs by Giemsa staining-based light microscopy
    		[PMID: 25025991]
    NCI/ADR-RES IC50
    6005 nM
    Compound: 1
    Cytotoxicity against P-gp overexpressing human MCF7/ADR cells assessed as reduction in cell growth after 24 hrs by MTT assay
    Cytotoxicity against P-gp overexpressing human MCF7/ADR cells assessed as reduction in cell growth after 24 hrs by MTT assay
    		[PMID: 27213819]
    NCI-H1299 IC50
    0.004 μM
    Compound: Colchicine
    Antiproliferative activity against human NCI-H1299 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
    Antiproliferative activity against human NCI-H1299 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
    		[PMID: 36511661]
    NCI-H1299 EC50
    0.034 μM
    Compound: colchicine
    Induction of apoptosis in human H1299 cells assessed as caspase activation after 24 hrs
    Induction of apoptosis in human H1299 cells assessed as caspase activation after 24 hrs
    		[PMID: 15566300]
    NCI-H1299 EC50
    0.05 μM
    Compound: colchicine
    Induction of apoptosis in human H1299 cells assessed as caspase activation after 48 hrs by HTS assay
    Induction of apoptosis in human H1299 cells assessed as caspase activation after 48 hrs by HTS assay
    		[PMID: 19464890]
    NCI-H1299 EC50
    0.05 μM
    Compound: Colchicine
    Induction of apoptosis in human H1299 cells assessed as caspase activation after 48 hrs
    Induction of apoptosis in human H1299 cells assessed as caspase activation after 48 hrs
    		[PMID: 19500976]
    NCI-H1299 GI50
    0.063 μM
    Compound: Colchicine
    Growth inhibition of human H1299 cells after 48 hrs
    Growth inhibition of human H1299 cells after 48 hrs
    		[PMID: 19500976]
    NCI-H1299 IC50
    30 nM
    Compound: colchicine
    Cytotoxicity against human H1299 cells after 72 hrs
    Cytotoxicity against human H1299 cells after 72 hrs
    		[PMID: 19530698]
    NCI-H1437 IC50
    0.002 μM
    Compound: Colchicine
    Antiproliferative activity against human NCI-H1437 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
    Antiproliferative activity against human NCI-H1437 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
    		[PMID: 36511661]
    NCI-H157 IC50
    0.01 μM
    Compound: 1
    Cytotoxicity in human NCI-H157 cells assessed as reduction in cell viability after 4 days under dark condition by MTT assay
    Cytotoxicity in human NCI-H157 cells assessed as reduction in cell viability after 4 days under dark condition by MTT assay
    		[PMID: 29172077]
    NCI-H23 IC50
    0.013 μM
    Compound: 1
    Cell cycle arrest in human NCI-H23 cells assessed as accumulation at G2/M phase after 24 hrs using propidium iodide staining by FACS analysis
    Cell cycle arrest in human NCI-H23 cells assessed as accumulation at G2/M phase after 24 hrs using propidium iodide staining by FACS analysis
    		[PMID: 21126027]
    NCI-H358 IC50
    0.02 μM
    Compound: Colchicine
    Cytotoxicity against human NCI-H358 cells by MTT assay
    Cytotoxicity against human NCI-H358 cells by MTT assay
    		[PMID: 23425970]
    NCI-H358 IC50
    4 nM
    Compound: colchicine
    Antiproliferative activity against human NCI-H358 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay
    Antiproliferative activity against human NCI-H358 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay
    		[PMID: 25208345]
    NCI-H460 IC50
    0.01 μM
    Compound: colchicine
    Antiproliferative activity against human NCI-H460 cells by XTT assay
    Antiproliferative activity against human NCI-H460 cells by XTT assay
    		[PMID: 19220018]
    NCI-H460 IC50
    0.021 μM
    Compound: Colchicine
    Cytotoxicity against human NCI-H460 cells assessed as growth inhibition by MTT assay
    Cytotoxicity against human NCI-H460 cells assessed as growth inhibition by MTT assay
    		[PMID: 25091926]
    NCI-H460 IC50
    0.022 μM
    Compound: Col
    Antiproliferative activity against human NCI-H460 cells after 48 hrs by MTT assay
    Antiproliferative activity against human NCI-H460 cells after 48 hrs by MTT assay
    		[PMID: 34311158]
    NCI-H460 IC50
    0.022 μM
    Compound: Colchicine
    Cytotoxicity against human H460 cells after 72 hrs by MTT assay
    Cytotoxicity against human H460 cells after 72 hrs by MTT assay
    		[PMID: 23932339]
    NCI-H460 IC50
    0.027 μM
    Compound: colchicine
    Antiproliferative activity against human NCI-H460 cells after 48 hrs by alamar blue assay
    Antiproliferative activity against human NCI-H460 cells after 48 hrs by alamar blue assay
    		[PMID: 21563750]
    NCI-H460 EC50
    0.03 μM
    Compound: 1
    Cytotoxicity against human H460 after 3 days by SRB assay
    Cytotoxicity against human H460 after 3 days by SRB assay
    		[PMID: 15730238]
    NCI-H460 IC50
    0.054 μM
    Compound: Colchicine
    Antiproliferative activity against human NCI-H460 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
    Antiproliferative activity against human NCI-H460 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
    		[PMID: 36511661]
    NCI-H460 IC50
    0.06 μM
    Compound: 2
    Cytotoxicity against human NCI-H460 cells after 68 hrs by MTT assay
    Cytotoxicity against human NCI-H460 cells after 68 hrs by MTT assay
    		[PMID: 32243160]
    NCI-H460 IC50
    0.07 μM
    Compound: 2
    Cytotoxicity against human NCI-H460 cells after 48 hrs by XTT assay
    Cytotoxicity against human NCI-H460 cells after 48 hrs by XTT assay
    		[PMID: 21705223]
    NCI-H460 IC50
    0.07 μM
    Compound: 2
    Antiproliferative activity against human NCI-H460 cells after 48 hrs by XTT assay
    Antiproliferative activity against human NCI-H460 cells after 48 hrs by XTT assay
    		[PMID: 20537765]
    NCI-H460 IC50
    0.07 μM
    Compound: colchicine
    Cytotoxicity against human NCI-H460 cells after 48 hrs by XTT assay
    Cytotoxicity against human NCI-H460 cells after 48 hrs by XTT assay
    		[PMID: 17973361]
    NCI-H460 IC50
    0.07 μM
    Compound: 2
    Antiproliferative activity against NCI-H460 cells by XTT assay after 48 hrs
    Antiproliferative activity against NCI-H460 cells by XTT assay after 48 hrs
    		[PMID: 17181164]
    NCI-H460 IC50
    0.07 μM
    Compound: 2 (Colchicine)
    Cytotoxic activity against cellular metabolic activity of Lung NCI-H460 tumor cell line using XTT proliferation assay after incubation with the compound for 48 h
    Cytotoxic activity against cellular metabolic activity of Lung NCI-H460 tumor cell line using XTT proliferation assay after incubation with the compound for 48 h
    		[PMID: 12852768]
    NCI-H460 IC50
    0.71 μM
    Compound: Colchicine
    Growth inhibition of human NCI-H460 cells after 72 hrs by MTT assay
    Growth inhibition of human NCI-H460 cells after 72 hrs by MTT assay
    		[PMID: 23747810]
    NCI-H460 IC50
    12 nM
    Compound: Colchicine
    Antiproliferative activity against human NCI-H460 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
    Antiproliferative activity against human NCI-H460 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
    		[PMID: 35084853]
    NCI-H460 IC50
    18 nM
    Compound: Colchicine
    Cytotoxicity against human H460 cells after 72 hrs by methylene blue dye assay
    Cytotoxicity against human H460 cells after 72 hrs by methylene blue dye assay
    		[PMID: 19586033]
    NCI-H460 IC50
    18 nM
    Compound: 1
    Growth inhibition of human H460 cells after 72 hrs by methylene blue dye assay
    Growth inhibition of human H460 cells after 72 hrs by methylene blue dye assay
    		[PMID: 19053773]
    NCI-H460 IC50
    19 nM
    Compound: colchichine
    Growth inhibition of human H460 cells after 72 hrs by methylene blue dye assay
    Growth inhibition of human H460 cells after 72 hrs by methylene blue dye assay
    		[PMID: 17685504]
    NCI-H460 IC50
    19.8 nM
    Compound: 6
    Antiproliferative activity against human H460 cells assessed as inhibition of cell growth after 72 hrs by methylene blue dye assay
    Antiproliferative activity against human H460 cells assessed as inhibition of cell growth after 72 hrs by methylene blue dye assay
    		10.1039/C0MD00052C
    NCI-H460 IC50
    19.8 nM
    Compound: 1
    Cytotoxicity against human H460 cells assessed as growth inhibition after 72 hrs by methylene blue staining-based assay
    Cytotoxicity against human H460 cells assessed as growth inhibition after 72 hrs by methylene blue staining-based assay
    		[PMID: 24106982]
    NCI-H460 IC50
    20 nM
    Compound: 5
    Antiproliferative activity against human H460 cells after 72 hrs by methylene blue assay
    Antiproliferative activity against human H460 cells after 72 hrs by methylene blue assay
    		[PMID: 21641700]
    NCI-H460 IC50
    20.1 nM
    Compound: 3
    Antiproliferative activity against human H460 cells after 72 hrs by methylene blue dye assay
    Antiproliferative activity against human H460 cells after 72 hrs by methylene blue dye assay
    		[PMID: 20148562]
    NCI-H460 IC50
    20.2 nM
    Compound: 4
    Growth inhibition of human H460 cells after 72 hrs by methylene blue dye assay
    Growth inhibition of human H460 cells after 72 hrs by methylene blue dye assay
    		[PMID: 18588280]
    NCI-H460 IC50
    27 μM
    Compound: Colchicine
    Cytotoxicity against human H460 cells by MTT assay
    Cytotoxicity against human H460 cells by MTT assay
    		[PMID: 23425970]
    NCI-H460 IC50
    35.8 nM
    Compound: Colchicine
    Antiproliferative activity against human NCI-H460 cells incubated for 72 hrs by MTT assay
    Antiproliferative activity against human NCI-H460 cells incubated for 72 hrs by MTT assay
    		[PMID: 34648295]
    NCI-H460 IC50
    49.29 μM
    Compound: 1
    Growth inhibition of human NCI-H460 cells incubated for 48 hrs by MTT assay
    Growth inhibition of human NCI-H460 cells incubated for 48 hrs by MTT assay
    		[PMID: 27172319]
    NCI-H460 IC50
    50.6 nM
    Compound: Colchicine
    Antiproliferative activity against human NCI-H460 cells after 72 hrs by sulforhodamine B assay
    Antiproliferative activity against human NCI-H460 cells after 72 hrs by sulforhodamine B assay
    		[PMID: 21480626]
    NCI-H520 GI50
    < 0.05 μM
    Compound: colchicine
    Compound was evaluated for growth inhibition against NCI-H520 cells using cellular assay
    Compound was evaluated for growth inhibition against NCI-H520 cells using cellular assay
    		[PMID: 9871709]
    NCI-H522 IC50
    0.014 μM
    Compound: 1
    Cell cycle arrest in human NCI-H522 cells assessed as accumulation at G2/M phase after 24 hrs using propidium iodide staining by FACS analysis
    Cell cycle arrest in human NCI-H522 cells assessed as accumulation at G2/M phase after 24 hrs using propidium iodide staining by FACS analysis
    		[PMID: 21126027]
    NCI-N87 IC50
    5.4 nM
    Compound: 1
    Cytotoxicity against human NCI-N87 cells assessed as cell viability after 4 days by MTS assay
    Cytotoxicity against human NCI-N87 cells assessed as cell viability after 4 days by MTS assay
    		[PMID: 24210503]
    NIH3T3 IC50
    0.0026 μM
    Compound: 1a
    Cytotoxicity against mouse NIH/3T3 cells after 24 hrs by MTT assay
    Cytotoxicity against mouse NIH/3T3 cells after 24 hrs by MTT assay
    		[PMID: 23524161]
    NIH3T3 IC50
    1117 nM
    Compound: 4; COL
    Cytotoxicity against mouse NIH/3T3 cells harboring MDR G185 after 48 hrs by MTT assay
    Cytotoxicity against mouse NIH/3T3 cells harboring MDR G185 after 48 hrs by MTT assay
    		[PMID: 30448418]
    NIH3T3 IC50
    25 nM
    Compound: 4; COL
    Cytotoxicity against mouse NIH/3T3 cells after 48 hrs by MTT assay
    Cytotoxicity against mouse NIH/3T3 cells after 48 hrs by MTT assay
    		[PMID: 30448418]
    NUGC-3 IC50
    0.01 μM
    Compound: Colchicine
    Anticancer activity against human NUGC3 cells after 72 hrs by MTS/PMS assay
    Anticancer activity against human NUGC3 cells after 72 hrs by MTS/PMS assay
    		[PMID: 20170097]
    OVCAR-8 IC50
    17 nM
    Compound: Colchicine
    Anticancer activity against human OVCAR8 cells after 96 hrs by SRB assay
    Anticancer activity against human OVCAR8 cells after 96 hrs by SRB assay
    		[PMID: 21557538]
    OVCAR-8 IC50
    30 nM
    Compound: 1
    Cytotoxicity against human OVCAR8 cells assessed as growth inhibition after 48 hrs by SRB assay
    Cytotoxicity against human OVCAR8 cells assessed as growth inhibition after 48 hrs by SRB assay
    		[PMID: 26132075]
    OVCAR-8 IC50
    30 nM
    Compound: 1
    Cytotoxicity against human OVCAR8 cells assessed as growth inhibition after 96 hrs by Giemsa staining-based light microscopy
    Cytotoxicity against human OVCAR8 cells assessed as growth inhibition after 96 hrs by Giemsa staining-based light microscopy
    		[PMID: 25025991]
    P388 IC50
    0.029 μM
    Compound: 1
    Antiproliferative activity against mouse P388 cells incubated for 72 hrs by Coulter counter method
    Antiproliferative activity against mouse P388 cells incubated for 72 hrs by Coulter counter method
    		[PMID: 32432867]
    P388 IC50
    24 nM
    Compound: Colchicine
    Antiproliferative activity against mouse P388 cells after 48 hrs by MTT assay
    Antiproliferative activity against mouse P388 cells after 48 hrs by MTT assay
    		[PMID: 2778449]
    P388D1 IC50
    28 nM
    Compound: Col
    Antiproliferative activity against human P388D1 after 48 hrs by SRB assay
    Antiproliferative activity against human P388D1 after 48 hrs by SRB assay
    		[PMID: 21920638]
    P388D1 IC50
    28 nM
    Compound: Col
    Antiproliferative activity against mouse P388D1 cells after 48 hrs by sulforhodamine B assay
    Antiproliferative activity against mouse P388D1 cells after 48 hrs by sulforhodamine B assay
    		[PMID: 21604746]
    PANC-1 GI50
    0.01 μM
    Compound: Colchicine
    Antiproliferative activity against human PANC1 cells after 48 hrs by SRB assay
    Antiproliferative activity against human PANC1 cells after 48 hrs by SRB assay
    		[PMID: 25827522]
    PANC-1 IC50
    0.021 μM
    Compound: Colchicine
    Cytotoxicity against human PANC1 cells assessed as growth inhibition after 72 hrs by MTT assay
    Cytotoxicity against human PANC1 cells assessed as growth inhibition after 72 hrs by MTT assay
    		[PMID: 25805446]
    PANC-1 IC50
    0.1 nM
    Compound: 1
    Antiproliferative activity against human PANC-1 cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay
    Antiproliferative activity against human PANC-1 cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay
    		[PMID: 32827941]
    PANC-1 IC50
    80 nM
    Compound: 1
    Cytotoxicity against 2D culture of human PANC1 cells measured after 72 hrs by MTT assay
    Cytotoxicity against 2D culture of human PANC1 cells measured after 72 hrs by MTT assay
    		[PMID: 27912174]
    PBMC IC50
    > 100 μM
    Compound: 1a
    Cytotoxicity against human PBMC cells after 24 hrs by MTT assay
    Cytotoxicity against human PBMC cells after 24 hrs by MTT assay
    		[PMID: 23524161]
    PBMC IC50
    > 10000 nM
    Compound: Colchicine
    Antiproliferative activity against human PBMC after 72 hrs by MTS assay
    Antiproliferative activity against human PBMC after 72 hrs by MTS assay
    		[PMID: 30099258]
    PC-3 GI50
    < 0.05 μM
    Compound: colchicine
    Compound was evaluated for growth inhibition against PC-3 cells using cellular assay
    Compound was evaluated for growth inhibition against PC-3 cells using cellular assay
    		[PMID: 9871709]
    PC-3 IC50
    0.01 μM
    Compound: Colchicine
    Antiproliferative activity against human PC3 cells after 96 hrs by SRB assay
    Antiproliferative activity against human PC3 cells after 96 hrs by SRB assay
    		[PMID: 22608389]
    PC-3 IC50
    0.01 μM
    Compound: Colchicine
    Antiproliferative activity against human PC3 cells after 96 hrs by sulforhodamine B assay
    Antiproliferative activity against human PC3 cells after 96 hrs by sulforhodamine B assay
    		[PMID: 21775150]
    PC-3 IC50
    0.011 μM
    Compound: colchicine
    Cytotoxicity against human PC3 cells after 48 hrs by SRB assay
    Cytotoxicity against human PC3 cells after 48 hrs by SRB assay
    		[PMID: 19243174]
    PC-3 IC50
    0.015 μM
    Compound: 1
    Growth inhibition of human PC3 cells incubated for 72 hrs by MTT assay
    Growth inhibition of human PC3 cells incubated for 72 hrs by MTT assay
    		[PMID: 27172319]
    PC-3 IC50
    0.018 μM
    Compound: colchicine
    Cytotoxicity against human PC3 cells after 3 days by MTT assay
    Cytotoxicity against human PC3 cells after 3 days by MTT assay
    		[PMID: 17275318]
    PC-3 IC50
    0.03 μM
    Compound: Colchicine
    Cytotoxicity against human PC-3 cells treated for 72 hrs by MTT assay
    Cytotoxicity against human PC-3 cells treated for 72 hrs by MTT assay
    		[PMID: 35344904]
    PC-3 IC50
    0.033 μM
    Compound: 1
    Cell cycle arrest in human PC3 cells assessed as accumulation at G2/M phase after 24 hrs using propidium iodide staining by FACS analysis
    Cell cycle arrest in human PC3 cells assessed as accumulation at G2/M phase after 24 hrs using propidium iodide staining by FACS analysis
    		[PMID: 21126027]
    PC-3 IC50
    0.04 μM
    Compound: Colchicine
    Cytotoxicity against human PC3 cells by MTT assay
    Cytotoxicity against human PC3 cells by MTT assay
    		[PMID: 23425970]
    PC-3 IC50
    0.042 μM
    Compound: 1
    Cytotoxicity against human PC-3 cells incubated for 48 hrs by MTT assay
    Cytotoxicity against human PC-3 cells incubated for 48 hrs by MTT assay
    		[PMID: 32432867]
    PC-3 IC50
    0.074 μM
    Compound: Colchicine
    Cytotoxicity against human PC3 cells after 72 hrs by MTT assay
    Cytotoxicity against human PC3 cells after 72 hrs by MTT assay
    		[PMID: 23602523]
    PC-3 IC50
    0.13 μM
    Compound: Colchicine
    Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay
    Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay
    		[PMID: 30075402]
    PC-3 IC50
    0.338 μM
    Compound: Colchicine
    Antiproliferative activity against human PC-3 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
    Antiproliferative activity against human PC-3 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
    		[PMID: 32682200]
    PC-3 IC50
    0.59 μM
    Compound: Colchicine
    Antiproliferative activity against human PC3 cells measured after 48 hrs by MTT assay
    Antiproliferative activity against human PC3 cells measured after 48 hrs by MTT assay
    		[PMID: 30690300]
    PC-3 IC50
    11 nM
    Compound: Colchicine
    Cytotoxicity against human PC3 cells after 48 hrs by sulforhodamine B assay
    Cytotoxicity against human PC3 cells after 48 hrs by sulforhodamine B assay
    		[PMID: 20919720]
    PC-3 IC50
    11.5 nM
    Compound: Colchicine
    Antiproliferative activity against human PC3 cells after 48 hrs by SRB assay
    Antiproliferative activity against human PC3 cells after 48 hrs by SRB assay
    		[PMID: 22783954]
    PC-3 IC50
    19 nM
    Compound: Colchicine
    Antiproliferative activity against human PC3 cells measured after 72 hrs by MTS assay
    Antiproliferative activity against human PC3 cells measured after 72 hrs by MTS assay
    		[PMID: 31860298]
    PC-3 IC50
    20 nM
    Compound: 1
    Cytotoxicity against human PC3 cells after 72 hrs by crystal violet staining
    Cytotoxicity against human PC3 cells after 72 hrs by crystal violet staining
    		[PMID: 20529690]
    PC-3 IC50
    8 nM
    Compound: Colchicine
    Cytotoxicity against human PC3 cells after 72 hrs by MTS assay
    Cytotoxicity against human PC3 cells after 72 hrs by MTS assay
    		[PMID: 29406710]
    PPC-1 IC50
    0.02 μM
    Compound: colchicine
    Cytotoxicity against human PPC1 cells after 48 hrs by SRB assay
    Cytotoxicity against human PPC1 cells after 48 hrs by SRB assay
    		[PMID: 19243174]
    PPC-1 IC50
    0.02 μM
    Compound: Colchicine
    Antiproliferative activity against human PPC1 cells after 96 hrs by sulforhodamine B assay
    Antiproliferative activity against human PPC1 cells after 96 hrs by sulforhodamine B assay
    		[PMID: 21775150]
    PPC-1 IC50
    20 nM
    Compound: Colchicine
    Cytotoxicity against human PPC1 cells after 48 hrs by sulforhodamine B assay
    Cytotoxicity against human PPC1 cells after 48 hrs by sulforhodamine B assay
    		[PMID: 20919720]
    Raji EC50
    0.014 μM
    Compound: Colchicine
    Cytotoxicity against human Raji cells after 48 hrs by luminescence cell viability assay
    Cytotoxicity against human Raji cells after 48 hrs by luminescence cell viability assay
    		[PMID: 18684625]
    Raji IC50
    16 nM
    Compound: 1
    Antiproliferative activity against human Raji cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay
    Antiproliferative activity against human Raji cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay
    		[PMID: 32827941]
    Raji IC50
    18 nM
    Compound: Colchicine
    Antiproliferative activity against human Raji cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
    Antiproliferative activity against human Raji cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
    		[PMID: 35084853]
    Ramos IC50
    2.13 nM
    Compound: Colchicine
    Antiproliferative activity against human Ramos cells incubated for 72 hrs by MTT assay
    Antiproliferative activity against human Ramos cells incubated for 72 hrs by MTT assay
    		[PMID: 34648295]
    REH IC50
    0.0095 μM
    Compound: 1a
    Cytotoxicity against human REH cells after 48 hrs by MTT assay
    Cytotoxicity against human REH cells after 48 hrs by MTT assay
    		[PMID: 23524161]
    RKO IC50
    > 10 μM
    Compound: 2
    Antiproliferative activity against human RKO cells expressing p27Kip1 after 48 hrs by XTT assay
    Antiproliferative activity against human RKO cells expressing p27Kip1 after 48 hrs by XTT assay
    		[PMID: 20537765]
    RKO IC50
    > 10 μM
    Compound: 2
    Antiproliferative activity against RKO cells with ectopic-induced p27kip1-expression by XTT assay after 48 hrs
    Antiproliferative activity against RKO cells with ectopic-induced p27kip1-expression by XTT assay after 48 hrs
    		[PMID: 17181164]
    RKO IC50
    > 14 μM
    Compound: colchicine
    Cytotoxicity against human RKO cells with ectopic-inducible expression of p27kip1 after 48 hrs by XTT assay
    Cytotoxicity against human RKO cells with ectopic-inducible expression of p27kip1 after 48 hrs by XTT assay
    		[PMID: 17973361]
    RKO IC50
    > 3 μM
    Compound: colchicine
    Antiproliferative activity against human RKO cells containing ecdysone-inducible expression vector of p27kipl by XTT assay
    Antiproliferative activity against human RKO cells containing ecdysone-inducible expression vector of p27kipl by XTT assay
    		[PMID: 19220018]
    RKO IC50
    > 5 μM
    Compound: Colchicine
    Cytotoxicity against cell cycle arrested RKOp27 cells after 72 hrs by alamar blue assay
    Cytotoxicity against cell cycle arrested RKOp27 cells after 72 hrs by alamar blue assay
    		[PMID: 16970401]
    RKO IC50
    0.01 μM
    Compound: colchicine
    Antiproliferative activity against human RKO cells by XTT assay
    Antiproliferative activity against human RKO cells by XTT assay
    		[PMID: 19220018]
    RKO IC50
    0.016 μM
    Compound: Colchicine
    Cytotoxicity against proliferating RKOp27 cells after 72 hrs by Alamar Blue assay
    Cytotoxicity against proliferating RKOp27 cells after 72 hrs by Alamar Blue assay
    		[PMID: 16970401]
    RKO IC50
    0.02 μM
    Compound: 2
    Antiproliferative activity against human RKO cells after 48 hrs by XTT assay
    Antiproliferative activity against human RKO cells after 48 hrs by XTT assay
    		[PMID: 20537765]
    RKO IC50
    0.02 μM
    Compound: colchicine
    Cytotoxicity against human RKO cells after 48 hrs by XTT assay
    Cytotoxicity against human RKO cells after 48 hrs by XTT assay
    		[PMID: 17973361]
    RKO IC50
    0.02 μM
    Compound: 2
    Antiproliferative activity against RKO cells by XTT assay after 48 hrs
    Antiproliferative activity against RKO cells by XTT assay after 48 hrs
    		[PMID: 17181164]
    RKO IC50
    0.043 μM
    Compound: Colchicine
    Antiproliferative activity against human RKO cells after 48 hrs by MTT assay
    Antiproliferative activity against human RKO cells after 48 hrs by MTT assay
    		[PMID: 30093295]
    RL IC50
    4.4 nM
    Compound: Colchicine
    Antiproliferative activity against human RL cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
    Antiproliferative activity against human RL cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
    		[PMID: 33618157]
    RPMI-7951 IC50
    13.8 nM
    Compound: Colchicine
    Antiproliferative activity against human RPMI-7951 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTS assay
    Antiproliferative activity against human RPMI-7951 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTS assay
    		[PMID: 34406768]
    RPMI-7951 IC50
    6.6 nM
    Compound: Colchicine
    Cytotoxicity against human RPMI7951 cells after 72 hrs by MTS assay
    Cytotoxicity against human RPMI7951 cells after 72 hrs by MTS assay
    		[PMID: 29406710]
    SF-268 IC50
    0.01 μM
    Compound: colchicine
    Antiproliferative activity against human SF268 cells by XTT assay
    Antiproliferative activity against human SF268 cells by XTT assay
    		[PMID: 19220018]
    SF-268 EC50
    0.025 μM
    Compound: 1
    Cytotoxicity against human SF-268 after 3 days by SRB assay
    Cytotoxicity against human SF-268 after 3 days by SRB assay
    		[PMID: 15730238]
    SF-268 IC50
    0.05 μM
    Compound: 2
    Cytotoxicity against human SF268 cells after 48 hrs by XTT assay
    Cytotoxicity against human SF268 cells after 48 hrs by XTT assay
    		[PMID: 21705223]
    SF-268 IC50
    0.05 μM
    Compound: 2
    Antiproliferative activity against human SF268 cells after 48 hrs by XTT assay
    Antiproliferative activity against human SF268 cells after 48 hrs by XTT assay
    		[PMID: 20537765]
    SF-268 IC50
    0.05 μM
    Compound: colchicine
    Cytotoxicity against human SF268 cells after 48 hrs by XTT assay
    Cytotoxicity against human SF268 cells after 48 hrs by XTT assay
    		[PMID: 17973361]
    SF-268 IC50
    0.05 μM
    Compound: 2
    Antiproliferative activity against SF268 cells by XTT assay after 48 hrs
    Antiproliferative activity against SF268 cells by XTT assay after 48 hrs
    		[PMID: 17181164]
    SF-268 IC50
    0.05 μM
    Compound: 2 (Colchicine)
    Cytotoxic activity against cellular metabolic activity of Glioma SF-268 tumor cell line using XTT proliferation assay after incubation with the compound for 48 h
    Cytotoxic activity against cellular metabolic activity of Glioma SF-268 tumor cell line using XTT proliferation assay after incubation with the compound for 48 h
    		[PMID: 12852768]
    SGC-7901 IC50
    0.007 μM
    Compound: Colchicine
    Antiproliferative activity against human SGC-7901 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
    Antiproliferative activity against human SGC-7901 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
    		[PMID: 34571171]
    SGC-7901 IC50
    0.05 μM
    Compound: Colchicine
    Cytotoxicity against human SGC7901 cells after 48 hrs
    Cytotoxicity against human SGC7901 cells after 48 hrs
    		[PMID: 23022053]
    SGC-7901 IC50
    0.134 μM
    Compound: 1
    Antiproliferative activity against human SGC7901 cells after 72 hrs by MTT assay
    Antiproliferative activity against human SGC7901 cells after 72 hrs by MTT assay
    		[PMID: 30245397]
    SH-SY5Y GI50
    0.04 μM
    Compound: Colchicine
    Antiproliferative activity against human SH-SY5Y cells after 48 hrs by MTT assay
    Antiproliferative activity against human SH-SY5Y cells after 48 hrs by MTT assay
    		[PMID: 28763647]
    SH-SY5Y IC50
    7.89 μM
    Compound: COL
    Antiproliferative activity against human SH-SY5Y cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
    Antiproliferative activity against human SH-SY5Y cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
    		[PMID: 35694693]
    SiHa IC50
    0.045 μM
    Compound: Col
    Antiproliferation activity against human SiHa cells assessed as reduction in cell growth measured after 48 to 72 hrs by CCK-8 assay
    Antiproliferation activity against human SiHa cells assessed as reduction in cell growth measured after 48 to 72 hrs by CCK-8 assay
    		[PMID: 35339837]
    SJSA-1 IC50
    0.008 μM
    Compound: Colchicine
    Cytotoxicity against human SJSA1 cells assessed as growth inhibition after 72 hrs by MTT assay
    Cytotoxicity against human SJSA1 cells assessed as growth inhibition after 72 hrs by MTT assay
    		[PMID: 25805446]
    SK-BR-3 ED50
    0.0027 μg/mL
    Compound: 1
    Cytotoxicity against human SKBR3 cells after 2 days
    Cytotoxicity against human SKBR3 cells after 2 days
    		[PMID: 20542428]
    SK-BR-3 IC50
    0.0064 μM
    Compound: Colchicine
    Growth inhibition of human SKBR3 cells after 48 hrs by MTT assay
    Growth inhibition of human SKBR3 cells after 48 hrs by MTT assay
    		[PMID: 22850214]
    SK-BR-3 IC50
    0.04 μM
    Compound: Colchicine
    Cytotoxicity against human SK-BR-3 cells treated for 72 hrs by MTT assay
    Cytotoxicity against human SK-BR-3 cells treated for 72 hrs by MTT assay
    		[PMID: 35344904]
    SK-HEP1 IC50
    0.17 μM
    Compound: Colchicine
    Cytotoxicity against human SKHEP1 cells by MTT assay
    Cytotoxicity against human SKHEP1 cells by MTT assay
    		[PMID: 23425970]
    SK-MEL-2 ED50
    0.008 μg/mL
    Compound: colchicine
    The compound was tested for the cytotoxicity for the cell lines of human melanoma cancer (SKMEL-2) using SRB assay.
    The compound was tested for the cytotoxicity for the cell lines of human melanoma cancer (SKMEL-2) using SRB assay.
    		[PMID: 9544215]
    SK-MEL-2 IC50
    6 nM
    Compound: 1; (-)-Colchicine
    Antiproliferative activity against human SK-MEL-2 cells assessed as reduction in cell viability incubated for 24 hrs by SRB assay
    Antiproliferative activity against human SK-MEL-2 cells assessed as reduction in cell viability incubated for 24 hrs by SRB assay
    		[PMID: 31655432]
    SK-MES-1 IC50
    18.6 nM
    Compound: 1
    Cytotoxicity against human SKMES1 cells after 48 hrs by Celltiter-Glo luminescent cell viability assay
    Cytotoxicity against human SKMES1 cells after 48 hrs by Celltiter-Glo luminescent cell viability assay
    		[PMID: 26985296]
    SK-OV-3 IC50
    0.01 μM
    Compound: colchicine
    Antiproliferative activity against human SKOV3 cells by XTT assay
    Antiproliferative activity against human SKOV3 cells by XTT assay
    		[PMID: 19220018]
    SK-OV-3 IC50
    0.02 μM
    Compound: Colchicine
    In vitro inhibitory activity against SK-OV-3 cells using XTT proliferation assay.
    In vitro inhibitory activity against SK-OV-3 cells using XTT proliferation assay.
    		[PMID: 11741473]
    SK-OV-3 IC50
    0.029 μM
    Compound: colchicine
    Antiproliferative activity against human SKOV3 cells after 48 hrs by alamar blue assay
    Antiproliferative activity against human SKOV3 cells after 48 hrs by alamar blue assay
    		[PMID: 21563750]
    SK-OV-3 IC50
    0.05 μM
    Compound: Colchicine
    Antiproliferative activity against human SKOV3 cells by SRB assay
    Antiproliferative activity against human SKOV3 cells by SRB assay
    		[PMID: 28988750]
    SK-OV-3 IC50
    0.05 μM
    Compound: 2
    Cytotoxicity against human SKOV3 cells after 48 hrs by XTT assay
    Cytotoxicity against human SKOV3 cells after 48 hrs by XTT assay
    		[PMID: 21705223]
    SK-OV-3 IC50
    0.05 μM
    Compound: 2
    Antiproliferative activity against human SKOV3 cells after 48 hrs by XTT assay
    Antiproliferative activity against human SKOV3 cells after 48 hrs by XTT assay
    		[PMID: 20537765]
    SK-OV-3 IC50
    0.05 μM
    Compound: colchicine
    Cytotoxicity against human SKOV3 cells after 48 hrs by XTT assay
    Cytotoxicity against human SKOV3 cells after 48 hrs by XTT assay
    		[PMID: 17973361]
    SK-OV-3 IC50
    0.05 μM
    Compound: 2
    Antiproliferative activity against SKOV3 cells by XTT assay after 48 hrs
    Antiproliferative activity against SKOV3 cells by XTT assay after 48 hrs
    		[PMID: 17181164]
    SK-OV-3 IC50
    0.05 μM
    Compound: 2 (Colchicine)
    Cytotoxic activity against cellular metabolic activity of Ovary SKOV3 tumor cell line using XTT proliferation assay after incubation with the compound for 48 h
    Cytotoxic activity against cellular metabolic activity of Ovary SKOV3 tumor cell line using XTT proliferation assay after incubation with the compound for 48 h
    		[PMID: 12852768]
    SK-OV-3 IC50
    0.12 μM
    Compound: Colchicine
    Cytotoxicity against human SKOV3 cells by MTT assay
    Cytotoxicity against human SKOV3 cells by MTT assay
    		[PMID: 23425970]
    SK-OV-3 IC50
    18 nM
    Compound: 1; (-)-Colchicine
    Antiproliferative activity against human SKOV3 cells assessed as reduction in cell viability incubated for 24 hrs by SRB assay
    Antiproliferative activity against human SKOV3 cells assessed as reduction in cell viability incubated for 24 hrs by SRB assay
    		[PMID: 31655432]
    SK-OV-3 IC50
    198 nM
    Compound: 1
    Cytotoxicity against human SKOV3 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay
    Cytotoxicity against human SKOV3 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay
    		[PMID: 30429975]
    SK-OV-3 IC50
    2.1 nM
    Compound: Col
    Antiproliferative activity against human SKOV3 after 48 hrs by SRB assay
    Antiproliferative activity against human SKOV3 after 48 hrs by SRB assay
    		[PMID: 21920638]
    SK-OV-3 IC50
    2.1 nM
    Compound: Col
    Antiproliferative activity against human SKOV3 cells after 48 hrs by sulforhodamine B assay
    Antiproliferative activity against human SKOV3 cells after 48 hrs by sulforhodamine B assay
    		[PMID: 21604746]
    SK-OV-3 IC50
    210 nM
    Compound: 1
    Cytotoxicity against arrested non-proliferative human SKOV3 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay
    Cytotoxicity against arrested non-proliferative human SKOV3 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay
    		[PMID: 30429975]
    SK-OV-3 IC50
    51.9 nM
    Compound: 1
    Antiproliferative activity against human SKOV3 cells after 24 hrs by MTT assay
    Antiproliferative activity against human SKOV3 cells after 24 hrs by MTT assay
    		[PMID: 27213819]
    SK-OV-3 IC50
    71.2 nM
    Compound: Colchicine
    Antiproliferative activity against human SKOV3 cells after 72 hrs by sulforhodamine B assay
    Antiproliferative activity against human SKOV3 cells after 72 hrs by sulforhodamine B assay
    		[PMID: 21480626]
    SNU-16 IC50
    0.005 μM
    Compound: Colchicine
    Cytotoxicity against human SNU16 cells assessed as growth inhibition after 72 hrs by MTT assay
    Cytotoxicity against human SNU16 cells assessed as growth inhibition after 72 hrs by MTT assay
    		[PMID: 25805446]
    SNU-398 EC50
    0.004 μM
    Compound: colchicine
    Induction of apoptosis in human SNU398 cells assessed as caspase activation after 24 hrs by HTS assay
    Induction of apoptosis in human SNU398 cells assessed as caspase activation after 24 hrs by HTS assay
    		[PMID: 18197614]
    SNU-423 IC50
    25 nM
    Compound: colchichine
    Cytotoxicity against human SNU423 cells after 48 hrs by alamar blue assay
    Cytotoxicity against human SNU423 cells after 48 hrs by alamar blue assay
    		[PMID: 19117761]
    SNU-5 IC50
    0.034 μM
    Compound: Colchicine
    Cytotoxicity against human SNU5 cells assessed as growth inhibition after 72 hrs by MTT assay
    Cytotoxicity against human SNU5 cells assessed as growth inhibition after 72 hrs by MTT assay
    		[PMID: 25805446]
    Splenocyte IC50
    2300 nM
    Compound: 3
    Immunosuppressant activity in mouse splenocytes by mixed-leukocyte reaction assay
    Immunosuppressant activity in mouse splenocytes by mixed-leukocyte reaction assay
    		[PMID: 23017885]
    SW1990 IC50
    0.01 μM
    Compound: Colchicine
    Antiproliferative activity against human SW1990 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
    Antiproliferative activity against human SW1990 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
    		[PMID: 36511661]
    SW480 IC50
    0.03 μM
    Compound: colchicine
    Antiproliferative activity against human SW480 cells after 48 hrs by alamar blue assay
    Antiproliferative activity against human SW480 cells after 48 hrs by alamar blue assay
    		[PMID: 21563750]
    SW480 IC50
    0.033 μM
    Compound: COL
    Antiproliferative activity against human SW480 cells after 48 hrs by SRB method
    Antiproliferative activity against human SW480 cells after 48 hrs by SRB method
    		[PMID: 25061803]
    SW480 IC50
    14.9 nM
    Compound: Colchicine
    Antiproliferative activity against human SW480 cells after 72 hrs by MTS assay
    Antiproliferative activity against human SW480 cells after 72 hrs by MTS assay
    		[PMID: 30099258]
    SW-620 IC50
    0.005 μM
    Compound: Colchicine
    Cytotoxicity against human SW620 cells assessed as growth inhibition after 72 hrs by MTT assay
    Cytotoxicity against human SW620 cells assessed as growth inhibition after 72 hrs by MTT assay
    		[PMID: 25805446]
    SW-620 IC50
    0.014 μM
    Compound: 1
    Cell cycle arrest in human SW620 cells assessed as accumulation at G2/M phase after 24 hrs using propidium iodide staining by FACS analysis
    Cell cycle arrest in human SW620 cells assessed as accumulation at G2/M phase after 24 hrs using propidium iodide staining by FACS analysis
    		[PMID: 21126027]
    SW-620 IC50
    2.4 nM
    Compound: 1
    Antiproliferative activity against human SW-620 cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay
    Antiproliferative activity against human SW-620 cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay
    		[PMID: 32827941]
    SW780 IC50
    6.7 nM
    Compound: colchicine
    Cytotoxicity against human SW780 cells after 96 hrs by MTT assay
    Cytotoxicity against human SW780 cells after 96 hrs by MTT assay
    		[PMID: 23176628]
    T47D GI50
    0.007 μM
    Compound: Colchicine
    Growth inhibition of human T47D cells after 48 hrs
    Growth inhibition of human T47D cells after 48 hrs
    		[PMID: 19282188]
    T47D GI50
    0.007 μM
    Compound: colchicine
    Growth inhibition of human T47D cells after 48 hrs
    Growth inhibition of human T47D cells after 48 hrs
    		[PMID: 18197614]
    T47D EC50
    0.009 μM
    Compound: colchicine
    Induction of apoptosis in human T47D cells assessed as caspase activation after 24 hrs by HTS assay
    Induction of apoptosis in human T47D cells assessed as caspase activation after 24 hrs by HTS assay
    		[PMID: 18197614]
    T47D EC50
    0.009 μM
    Compound: colchicine
    Induction of apoptosis in human T47D cells assessed as caspase activation after 48 hrs by HTS assay
    Induction of apoptosis in human T47D cells assessed as caspase activation after 48 hrs by HTS assay
    		[PMID: 19464890]
    T47D EC50
    0.009 μM
    Compound: colchicine
    Induction of apoptosis in human T47D cells assessed as caspase 3 activation after 24 hrs
    Induction of apoptosis in human T47D cells assessed as caspase 3 activation after 24 hrs
    		[PMID: 18651728]
    T47D EC50
    0.014 μM
    Compound: colchicine
    Induction of apoptosis in human T47D cells assessed as caspase activation after 24 hrs
    Induction of apoptosis in human T47D cells assessed as caspase activation after 24 hrs
    		[PMID: 15566300]
    T47D EC50
    0.014 μM
    Compound: Colchicine
    Induction of apoptosis in human T47D cells assessed as caspase activation after 48 hrs
    Induction of apoptosis in human T47D cells assessed as caspase activation after 48 hrs
    		[PMID: 19500976]
    T47D GI50
    0.14 μM
    Compound: Colchicine
    Growth inhibition of human T47D cells after 48 hrs
    Growth inhibition of human T47D cells after 48 hrs
    		[PMID: 19500976]
    T-cell IC50
    548 nM
    Compound: 1
    Immunosuppressive activity in concanavalin A-activated T cell assessed as inhibition of lymphoproliferation after 3 days by beta-scintillation counting
    Immunosuppressive activity in concanavalin A-activated T cell assessed as inhibition of lymphoproliferation after 3 days by beta-scintillation counting
    		[PMID: 19502058]
    TERT-RPE1 CC50
    0.1 μM
    Compound: Colchicine
    Cytotoxicity against hTERT-RPE1 cells assessed as reduction in cell viability after 72 hrs by sulforhodamine B assay
    Cytotoxicity against hTERT-RPE1 cells assessed as reduction in cell viability after 72 hrs by sulforhodamine B assay
    		[PMID: 30288225]
    THP-1 IC50
    2.49 nM
    Compound: Colchicine
    Antiproliferative activity against human THP-1 cells incubated for 72 hrs by MTT assay
    Antiproliferative activity against human THP-1 cells incubated for 72 hrs by MTT assay
    		[PMID: 34648295]
    THP-1 IC50
    20.4 nM
    Compound: 1
    Cytotoxicity against human THP1 cells after 24 hrs by Celltiter-Glo luminescent cell viability assay
    Cytotoxicity against human THP1 cells after 24 hrs by Celltiter-Glo luminescent cell viability assay
    		[PMID: 26985296]
    U-251 IC50
    0.017 μM
    Compound: Col
    Antiproliferative activity against human U-251 cells after 48 hrs by MTT assay
    Antiproliferative activity against human U-251 cells after 48 hrs by MTT assay
    		[PMID: 34311158]
    U-251 IC50
    20 nM
    Compound: colchicine
    Antiproliferative activity against human U251 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay
    Antiproliferative activity against human U251 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay
    		[PMID: 25208345]
    U-266 IC50
    0.01 μM
    Compound: 1
    Cell cycle arrest in human U266 cells assessed as accumulation at G2/M phase after 24 hrs using propidium iodide staining by FACS analysis
    Cell cycle arrest in human U266 cells assessed as accumulation at G2/M phase after 24 hrs using propidium iodide staining by FACS analysis
    		[PMID: 21126027]
    U-937 IC50
    0.008 μM
    Compound: Colchicine
    Antiproliferative activity against human U937 cells by sulforhodamine B assay
    Antiproliferative activity against human U937 cells by sulforhodamine B assay
    		[PMID: 20334421]
    U-937 IC50
    0.1 μg/mL
    Compound: Colchicine
    Cytotoxicity against human U937 cells after 48 hrs by MTT assay
    Cytotoxicity against human U937 cells after 48 hrs by MTT assay
    		[PMID: 15165134]
    Vero EC50
    0.27 μM
    Compound: Colchicine
    Cell cycle arrest in african green monkey Vero cells assessed as accumulation at G2/M phase after 18 hrs by flow cytometry using propidium iodide staining
    Cell cycle arrest in african green monkey Vero cells assessed as accumulation at G2/M phase after 18 hrs by flow cytometry using propidium iodide staining
    		[PMID: 18684625]
    Vero EC50
    0.39 μM
    Compound: Colchicine
    Induction of apoptosis in african green monkey Vero cells assessed as caspase 3/7 activity after 18 hrs by flow cytometry using propidium iodide staining
    Induction of apoptosis in african green monkey Vero cells assessed as caspase 3/7 activity after 18 hrs by flow cytometry using propidium iodide staining
    		[PMID: 18684625]
    Vero EC50
    0.53 μM
    Compound: Colchicine
    Cytotoxicity against african green monkey Vero cells after 48 hrs by luminescence cell viability assay
    Cytotoxicity against african green monkey Vero cells after 48 hrs by luminescence cell viability assay
    		[PMID: 18684625]
    WI-38 EC50
    0.022 μM
    Compound: Colchicine
    Antiviral activity against BKV Gardner ATCC VR837 infected in human WI38 cells assessed as reduction in viral DNA level preincubated for 2 hrs before viral infection measured after 7 days by real time PCR assay
    Antiviral activity against BKV Gardner ATCC VR837 infected in human WI38 cells assessed as reduction in viral DNA level preincubated for 2 hrs before viral infection measured after 7 days by real time PCR assay
    		[PMID: 17893158]
    WI-38 CC50
    0.0476 μM
    Compound: Colchicine
    Cytotoxicity against human WI38 cells assessed as reduction in cellular DNA level preincubated for 2 hrs before viral infection measured after 7 days by real time PCR assay
    Cytotoxicity against human WI38 cells assessed as reduction in cellular DNA level preincubated for 2 hrs before viral infection measured after 7 days by real time PCR assay
    		[PMID: 17893158]
    WM164 IC50
    0.03 μM
    Compound: Colchicine
    Antiproliferative activity against human WM164 cells after 48 hrs by SRB assay
    Antiproliferative activity against human WM164 cells after 48 hrs by SRB assay
    		[PMID: 22608389]
    WM164 IC50
    0.03 μM
    Compound: Colchicine
    Antiproliferative activity against human WM164 cells after 48 hrs by sulforhodamine B assay
    Antiproliferative activity against human WM164 cells after 48 hrs by sulforhodamine B assay
    		[PMID: 21775150]
    WM164 IC50
    10.8 nM
    Compound: Colchicine
    Antiproliferative activity against human WM164 cells after 72 hrs by MTT assay
    Antiproliferative activity against human WM164 cells after 72 hrs by MTT assay
    		[PMID: 31251599]
    WM164 IC50
    29 nM
    Compound: Colchicine
    Antiproliferative activity against human WM164 cells after 48 hrs by SRB assay
    Antiproliferative activity against human WM164 cells after 48 hrs by SRB assay
    		[PMID: 22783954]
    ZR-75-1 ED50
    0.1 μg/mL
    Compound: Colchicine
    Cytotoxicity against human ZR-75-1 cells after 3 days by SRB assay
    Cytotoxicity against human ZR-75-1 cells after 3 days by SRB assay
    		[PMID: 7528785]
    In Vitro

    Colchicine (5 μM; pretreated 24 h) inhibits MIRI-induced apoptosis of H9C2 by regulating the PI3K/AKT/eNOS pathway[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Colchicine Related Antibodies

    Apoptosis Analysis[3]

    Cell Line: H9C2 cells
    Concentration: 5 μM
    Incubation Time: Pretreated 24 h
    Result: Caused a significant reduction (4.490%) of early apoptotic cells as compared with the H/R only groups (6.182%).

    Western Blot Analysis[3]

    Cell Line: H9C2 cells
    Concentration: 5 μM
    Incubation Time: Pretreated 24 h
    Result: Observably increased the decreased phosphorylation levels of PI3K, AKT, and eNOS after H/R injury in H9C2 cell.
    In Vivo

    Colchicine can be used to induce Alzheimer's disease models[6].

    Induction of Alzheimer’s disease (AD)[6]
    Background
    Colchicine is a tubulin inhibitor that binds irreversibly to tubulin dimers and inhibits microtubule assembly with disruption of their polymerization, leading to neurofibrillary degeneration and synaptic loss. This causes neurotrophic factor intracellular trafficking to be disrupted, as well as axonal excitotoxicity and oxidative damage.
    Specific Mmodeling Methods
    Rat: Wistar • male • adult, weighing 180-220 g (acclimate: 1 weeks)
    Administration: 7.5 μg in 5 μL/site • intracerebroventricular (icv) injection • single dose
    Note
    (1) For induction of AD, rats are anesthetized using intraperitoneal (i.p.) Thiopental sodium (45 mg/kg) and then positioned in stereotaxic apparatus.
    (2) The stereotaxic coordinates are 0.8 mm posterior to bregma, 1.8 mm lateral to sagittal suture and 3.6 mm beneath the cortical surface.
    (3) Using a 28-gauge micro-syringe (10 μL) 15 μg Colchicine dissolved in 10 μL ACSF is injected bilaterally into the lateral ventricle (7.5 μg in 5 μL/site). The injection rate is 2 μL/min, then the micro-syringe is remained in place for 2 min to avoid withdrawal of the injected fluid.
    (4) Artificial cerebrospinal fluid (ACSF constituents in milli mole: NaCl 147, MgCl2 1.6, KCl 2.9, CaCl2 1.7, and Dextrose 2.2) is freshly prepared.
    Modeling Indicators
    Molecular changes: Induced indicators: Aβ 1-40 and Aβ 1-42 peptides level, MDA concentration, TNF-α level in both hippocampus and prefrontal cortex
    Decrease indicators: SOD activity in both hippocampus and prefrontal cortex
    Correlated Product(s): β-Amyloid (1-42), human TFA (HY-P1363)
    Opposite Product(s): Sacubitril/Valsartan (HY-18204A)

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Specific-pathogen-free 8-week-old male mice (Wild-type C57BL/6 mice)[4]
    Dosage: 1 or 3 mg/kg
    Administration: Orally; 30 min prior to Indomethacin administration
    Result: Caused less mucosal inflammation and ulceration and a decrease in the size and numbers of lesions compared with vehicle-treated mice with Indomethacin (10 mg/kg; gavage).
    Clinical Trial
    Molecular Weight

    399.44

    Formula

    C22H25NO6
    CAS No.

    64-86-8
    Appearance

    Solid

    Color

    White to light yellow

    SMILES

    CC(N[C@H](C1=C2)CCC3=CC(OC)=C(OC)C(OC)=C3C1=CC=C(OC)C2=O)=O
    Structure Classification
    • Others
    Initial Source
    • Plants
    • other families
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 2 years
    -20°C 1 year
    Solvent & Solubility
    In Vitro: 

    DMSO : 100 mg/mL (250.35 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    H2O : ≥ 33.33 mg/mL (83.44 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.5035 mL 12.5175 mL 25.0350 mL
    5 mM 0.5007 mL 2.5035 mL 5.0070 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  50% PEG400    50% Saline

      Solubility: 25 mg/mL (62.59 mM); Clear solution; Need ultrasonic

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 2.78 mg/mL (6.96 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.95%

    SDS (644 KB)

    COA (262 KB) HNMR (276 KB) RP-HPLC (243 KB) LCMS (93 KB)

    Handling Instructions (2659 KB)
    References

    • [1]. Bonfoco E, et al. Colchicine induces apoptosis in cerebellar granule cells. Exp Cell Res. 1995 May;218(1):189-200.  [Content Brief]

      [2]. Hastie SB. Interactions of colchicine with tubulin. Pharmacol Ther. 1991;51(3):377-401  [Content Brief]

      [3]. Yuanjun Tang, et al. Network Pharmacology-Based Investigation and Experimental Exploration of the Antiapoptotic Mechanism of Colchicine on Myocardial Ischemia Reperfusion Injury. Front Pharmacol. 2021 Dec 16:12:804030.  [Content Brief]

      [4]. Otani K, et al. Colchicine prevents NSAID-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome. Sci Rep. 2016 Sep 2;6:32587.  [Content Brief]

      [5]. Carola Muñoz-Montesino, et al. Inhibition of the Glycine Receptor alpha 3 Function by Colchicine. Front Pharmacol. 2020 Jul 30;11:1143.  [Content Brief]

      [6]. Sami H Hammadi, et al. Effect of sacubitril/valsartan on cognitive impairment in colchicine-induced Alzheimer's model in rats. Fundam Clin Pharmacol. 2023 Apr;37(2):275-286.  [Content Brief]

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O / DMSO 1 mM 2.5035 mL 12.5175 mL 25.0350 mL 62.5876 mL
    5 mM 0.5007 mL 2.5035 mL 5.0070 mL 12.5175 mL
    10 mM 0.2504 mL 1.2518 mL 2.5035 mL 6.2588 mL
    15 mM 0.1669 mL 0.8345 mL 1.6690 mL 4.1725 mL
    20 mM 0.1252 mL 0.6259 mL 1.2518 mL 3.1294 mL
    25 mM 0.1001 mL 0.5007 mL 1.0014 mL 2.5035 mL
    30 mM 0.0835 mL 0.4173 mL 0.8345 mL 2.0863 mL
    40 mM 0.0626 mL 0.3129 mL 0.6259 mL 1.5647 mL
    50 mM 0.0501 mL 0.2504 mL 0.5007 mL 1.2518 mL
    60 mM 0.0417 mL 0.2086 mL 0.4173 mL 1.0431 mL
    80 mM 0.0313 mL 0.1565 mL 0.3129 mL 0.7823 mL
    DMSO 100 mM 0.0250 mL 0.1252 mL 0.2504 mL 0.6259 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Colchicine Related Classifications

    Help & FAQs

    Keywords:

    Colchicine64-86-8Microtubule/TubulinNOD-like Receptor (NLR)AutophagyApoptosisOrallyalkaloidtubulinmicrotubuleα3 glycine receptorsGlyRsnon-steroidal anti-inflammatory drugNSAIDintestinal injuryimmunosuppressiveanti-fibrosisgouty arthritisAlzheimer’s diseaseADInhibitorinhibitorinhibit

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