Size : 10mg
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Cell lines
Rat primary hepatic stellate cells (HSCs)
Reaction Conditions
500 μmol/L camostat mesilate for 7 d incubation
Applications
Camostat mesilate (500 μmol/L) inhibited generation of transforming growth factor β (TGF-β) by suppressing plasmin activity and reduced the activity of TGF-β, which blocked in vitro activation of HSCs.
Animal models
Male Wistar rats
Dosage form
1 ~ 2 mg/g
Diet
Camostat mesilate (1 ~ 2 mg/g of diet) markedly attenuated an increase in hepatic plasmin and TGF-β levels, HSC activation, and hepatic fibrosis without apparent systemic or local side effects in porcine serum-treated rats. Therefore, camostat mesilate prevented porcine serum-induced rat hepatic fibrosis via a profound reduction in TGF-β generation
Note
The technical data provided above is for reference only.
References:
1. Okuno M, Akita K, Moriwaki H, et al. Prevention of rat hepatic fibrosis by the protease inhibitor, camostat mesilate, via reduced generation of active TGF-beta. Gastroenterology, 2001, 120(7): 1784-1800.
