General Info
Host: | Rabbit |
Applications: | ELISA/IHC/IP/WB |
Reactivity: | Human/Mouse/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-YME1L1 (720-773) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications. |
Clonality: | Polyclonal |
Conjugation: | Biotin |
Isotype: | IgG |
Purification: | Affinity Purified |
Concentration: | 0.5 µg/µl |
Dilution Range: | WB: 1:500 ELISA: 1:10, 000 IP: 1:200 IHC: 1:100 |
Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Information
Gene Symbol: | YME1L1 |
Gene ID: | 10730 |
Uniprot ID: | YMEL1_HUMAN |
Immunogen Region: | 720-773 |
Immunogen: | Synthetic peptide taken within amino acid region 720-773 on human ATP-dependent metalloprotease YME1L1 protein. |
Description
Tissue Specificity | High expression in cardiac and skeletal muscle mitochondria. |
Post Translational Modifications | Proteolytically processed by mitochondrial processing peptidase (MPP) to generate the mature form. |
Function | ATP-dependent metalloprotease that catalyzes the degradation of folded and unfolded proteins with a suitable degron sequence in the mitochondrial intermembrane region. Plays an important role in regulating mitochondrial morphology and function by cleaving OPA1 at position S2, giving rise to a form of OPA1 that promotes maintenance of normal mitochondrial structure and mitochondrial protein metabolism. Ensures cell proliferation, maintains normal cristae morphology and complex I respiration activity, promotes antiapoptotic activity and protects mitochondria from the accumulation of oxidatively damaged membrane proteins. Required for normal, constitutive degradation of PRELID1. Catalyzes the degradation of OMA1 in response to membrane depolarization. Required to control the accumulation of nonassembled respiratory chain subunits (NDUFB6, OX4 and ND1). |
Protein Name | Atp-Dependent Zinc Metalloprotease Yme1l1 Atp-Dependent Metalloprotease Ftsh1 Meg-4 Presenilin-Associated Metalloprotease Pamp Yme1-Like Protein 1 |
Database Links | Reactome: R-HSA-8949664 |
Cellular Localisation | Mitochondrion Inner Membrane Mitochondrion |
Alternative Antibody Names | Anti-Atp-Dependent Zinc Metalloprotease Yme1l1 antibody Anti-Atp-Dependent Metalloprotease Ftsh1 antibody Anti-Meg-4 antibody Anti-Presenilin-Associated Metalloprotease antibody Anti-Pamp antibody Anti-Yme1-Like Protein 1 antibody Anti-YME1L1 antibody Anti-FTSH1 antibody Anti-YME1L antibody Anti-UNQ1868 antibody Anti-PRO4304 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance