Anti-TLR9 antibody (430-460) {Biotin}

Clonality:	Polyclonal
Conjugation:	Biotin
Isotype:	IgG
Purification:	Affinity Purified
Concentration:	0.57-0.76 µg/µl
Dilution Range:	WB: 1:500 DB: 1:20, 000 ELISA: 1:20, 000 IP: 1:200 IHC: 1:100
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	TLR9
Gene ID:	54106
Uniprot ID:	TLR9_HUMAN
Immunogen Region:	430-460
Immunogen:	Synthetic peptide taken within amino acid region 430-460 on human TLR9 protein.

Tissue Specificity	Highly expressed in spleen, lymph node, tonsil and peripheral blood leukocytes, especially in plasmacytoid pre-dendritic cells. Levels are much lower in monocytes and CD11c+ immature dendritic cells. Also detected in lung and liver.
Post Translational Modifications	Activated by proteolytic cleavage of the flexible loop between repeats LRR14 and LRR15 within the ectodomain. Cleavage requires UNC93B1. Proteolytically processed by first removing the majority of the ectodomain by either asparagine endopeptidase (AEP) or a cathepsin followed by a trimming event that is solely cathepsin mediated and required for optimal receptor signaling.
Function	Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Controls lymphocyte response to Helicobacter infection. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production.
Protein Name	Toll-Like Receptor 9 Cd Antigen Cd289
Database Links	Reactome: R-HSA-109704 Reactome: R-HSA-1679131 Reactome: R-HSA-168138 Reactome: R-HSA-9679191 Reactome: R-HSA-975110 Reactome: R-HSA-975138 Reactome: R-HSA-975155
Cellular Localisation	Endoplasmic Reticulum Membrane Single-Pass Type I Membrane Protein Endosome Lysosome Cytoplasmic Vesicle Phagosome Relocalizes From Endoplasmic Reticulum To Endosome And Lysosome Upon Stimulation With Agonist Exit From The Er Requires Unc93b1 Endolysosomal Localization Is Required For Proteolytic Cleavage And Subsequent Activation Intracellular Localization Of The Active Receptor May Prevent From Responding To Self Nucleic Acid
Alternative Antibody Names	Anti-Toll-Like Receptor 9 antibody Anti-Cd Antigen Cd289 antibody Anti-TLR9 antibody Anti-UNQ5798 antibody Anti-PRO19605 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance