(S)-(+)-Ibuprofen [51146-56-6]
Cat# HY-78131A-1g
Size : 1g
Brand : MedChemExpress
(S)-(+)-Ibuprofen ((S)-Ibuprofen), a S(+)-enantiomer of Ibuprofen, is a potent COX-1 and COX-2 inhibitor with IC50s of 2.1 μM and 1.6 μM, respectively. (S)-(+)-Ibuprofen has analgesic, anti-inflammatory, anticancer and antipyretic effects.
For research use only. We do not sell to patients.
(S)-(+)-Ibuprofen Chemical Structure
CAS No. : 51146-56-6
This product is a controlled substance and not for sale in your territory.
Based on 1 publication(s) in Google Scholar
Other Forms of (S)-(+)-Ibuprofen:
- Ibuprofen In-stock
- (S)-(+)-Ibuprofen-d3 In-stock
- (R)-(-)-Ibuprofen In-stock
- Ibuprofen sodium In-stock
- Ibuprofen-d3 In-stock
View All COX Isoform Specific Products:
Description |
(S)-(+)-Ibuprofen ((S)-Ibuprofen), a S(+)-enantiomer of Ibuprofen, is a potent COX-1 and COX-2 inhibitor with IC50s of 2.1 μM and 1.6 μM, respectively. (S)-(+)-Ibuprofen has analgesic, anti-inflammatory, anticancer and antipyretic effects[1][2]. |
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IC50 & Target[1] |
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In Vitro |
(S)-(+)-Ibuprofen (HCT-15 and HCA-7 cells; 0-1000 μM; 8 days) treatment reduces concentration dependently cell survival in both cell lines to a similar extent[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation Assay[2]
Cell Cycle Analysis[2]
Apoptosis Analysis[2]
Western Blot Analysis[2]
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In Vivo |
(S)-(+)-Ibuprofen (15 mg/kg/day; intraperitoneal injection; five days a week; for 4 weeks) treatment inhibits tumor growth of HCA-7 and HCT-15 xenografts in the nude mice model[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Clinical Trial |
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Molecular Weight |
206.28 |
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Formula |
C13H18O2 |
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CAS No. |
51146-56-6 |
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Appearance |
Solid |
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Color |
White to off-white |
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SMILES |
OC([C@H](C1=CC=C(CC(C)C)C=C1)C)=O |
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Shipping | Room temperature in continental US; may vary elsewhere. |
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Storage |
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Solvent & Solubility |
In Vitro:
DMSO : 100 mg/mL (484.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) Ethanol : 100 mg/mL (484.78 mM; Need ultrasonic) H2O : 1 mg/mL (4.85 mM; Need ultrasonic and warming) Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles. * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
For the following dissolution methods, please prepare the working solution directly.
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO
+
%
+
%
Tween-80
+
%
Saline
The co-solvents required include: DMSO,
. All of co-solvents are available by MedChemExpress (MCE).
, Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration:
mg/mL
Method for preparing stock solution:
mg
drug dissolved in
μL
DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take
μL DMSO stock solution, add
μL .
μL , mix evenly, next add
μL Tween 80, mix evenly, then add
μL Saline.
If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
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Purity & Documentation |
Purity: 99.98% |
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References |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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H2O / DMSO / Ethanol | 1 mM | 4.8478 mL | 24.2389 mL | 48.4778 mL | 121.1945 mL |
DMSO / Ethanol | 5 mM | 0.9696 mL | 4.8478 mL | 9.6956 mL | 24.2389 mL |
10 mM | 0.4848 mL | 2.4239 mL | 4.8478 mL | 12.1194 mL | |
15 mM | 0.3232 mL | 1.6159 mL | 3.2319 mL | 8.0796 mL | |
20 mM | 0.2424 mL | 1.2119 mL | 2.4239 mL | 6.0597 mL | |
25 mM | 0.1939 mL | 0.9696 mL | 1.9391 mL | 4.8478 mL | |
30 mM | 0.1616 mL | 0.8080 mL | 1.6159 mL | 4.0398 mL | |
40 mM | 0.1212 mL | 0.6060 mL | 1.2119 mL | 3.0299 mL | |
50 mM | 0.0970 mL | 0.4848 mL | 0.9696 mL | 2.4239 mL | |
60 mM | 0.0808 mL | 0.4040 mL | 0.8080 mL | 2.0199 mL | |
80 mM | 0.0606 mL | 0.3030 mL | 0.6060 mL | 1.5149 mL | |
100 mM | 0.0485 mL | 0.2424 mL | 0.4848 mL | 1.2119 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
(S)-(+)-Ibuprofen Related Classifications
- Immunology/Inflammation
- COX