VIT-2763 [2095668-10-1]
Cat# HY-112220-5mg
Size : 5mg
Brand : MedChemExpress
VIT-2763, an oral ferroportin inhibitor, inhibits hepcidin binding to ferroportin and blocks iron efflux. VIT-2763 has the potential in the treatment of β-thalassemia.
For research use only. We do not sell to patients.
VIT-2763 Chemical Structure
CAS No. : 2095668-10-1
This product is a controlled substance and not for sale in your territory.
Based on 1 publication(s) in Google Scholar
Description |
VIT-2763, an oral ferroportin inhibitor, inhibits hepcidin binding to ferroportin and blocks iron efflux. VIT-2763 has the potential in the treatment of β-thalassemia[1]. |
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In Vitro |
VIT-2763 dose dependently reduces the fluorescence polarization signal, indicating that VIT-2763 displaces TMR-hepcidin from ferroportin (IC50 of 24 ± 13 nM)[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability Assay[1].
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In Vivo |
VIT-2763 (30, 100 mg/kg, orally twice daily for 36 days) decreases serum iron and prevented liver iron loading in Hbbth3/+ mice[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Clinical Trial |
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Molecular Weight |
408.43 |
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Formula |
C21H21FN6O2 |
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CAS No. |
2095668-10-1 |
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Appearance |
Solid |
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Color |
Off-white to light yellow |
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SMILES |
O=C(C1=COC(CCNCCC2=NC3=CC=CC=C3N2)=N1)NCC4=NC=CC=C4F |
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Shipping | Room temperature in continental US; may vary elsewhere. |
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Storage |
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Solvent & Solubility |
In Vitro:
DMSO : 83.33 mg/mL (204.03 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO
+
%
+
%
Tween-80
+
%
Saline
The co-solvents required include: DMSO,
. All of co-solvents are available by MedChemExpress (MCE).
, Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration:
mg/mL
Method for preparing stock solution:
mg
drug dissolved in
μL
DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take
μL DMSO stock solution, add
μL .
μL , mix evenly, next add
μL Tween 80, mix evenly, then add
μL Saline.
If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
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Purity & Documentation | |||||||||||||
References |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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DMSO | 1 mM | 2.4484 mL | 12.2420 mL | 24.4840 mL | 61.2100 mL |
5 mM | 0.4897 mL | 2.4484 mL | 4.8968 mL | 12.2420 mL | |
10 mM | 0.2448 mL | 1.2242 mL | 2.4484 mL | 6.1210 mL | |
15 mM | 0.1632 mL | 0.8161 mL | 1.6323 mL | 4.0807 mL | |
20 mM | 0.1224 mL | 0.6121 mL | 1.2242 mL | 3.0605 mL | |
25 mM | 0.0979 mL | 0.4897 mL | 0.9794 mL | 2.4484 mL | |
30 mM | 0.0816 mL | 0.4081 mL | 0.8161 mL | 2.0403 mL | |
40 mM | 0.0612 mL | 0.3061 mL | 0.6121 mL | 1.5303 mL | |
50 mM | 0.0490 mL | 0.2448 mL | 0.4897 mL | 1.2242 mL | |
60 mM | 0.0408 mL | 0.2040 mL | 0.4081 mL | 1.0202 mL | |
80 mM | 0.0306 mL | 0.1530 mL | 0.3061 mL | 0.7651 mL | |
100 mM | 0.0245 mL | 0.1224 mL | 0.2448 mL | 0.6121 mL |
VIT-2763 Related Classifications
- Membrane Transporter/Ion Channel
- Ferroportin