Tezacaftor [1152311-62-0]
Cat# HY-15448-5mg
Size : 5mg
Brand : MedChemExpress
Tezacaftor (VX-661) is a F508del CFTR corrector. It helps CFTR protein reach the cell surface. However, Ivacaftor (VX-770, HY-13017), a CFTR potentiator, helps to prolong the opening time of cell surface CFTR protein channels. Tezacaftor combining with Ivacaftor, shows potent efficacy against cystic fibrosis and diseases with homozygous for the CFTR Phe508del mutation. Moreover, Elexacaftor (VX-445, HY-111772) is also a CFTR corrector. Elexacaftor-Tezacaftor-Ivacaftor aims at with cystic fibrosis (CF) with at least one Phe508del mutation, often avoids the indication for lung transplantation.
For research use only. We do not sell to patients.
Tezacaftor Chemical Structure
CAS No. : 1152311-62-0
This product is a controlled substance and not for sale in your territory.
Based on 9 publication(s) in Google Scholar
Other Forms of Tezacaftor:
- Tezacaftor-d4 In-stock
- (Rac)-Tezacaftor Get quote
Description |
Tezacaftor (VX-661) is a F508del CFTR corrector. It helps CFTR protein reach the cell surface. However, Ivacaftor (VX-770, HY-13017), a CFTR potentiator, helps to prolong the opening time of cell surface CFTR protein channels. Tezacaftor combining with Ivacaftor, shows potent efficacy against cystic fibrosis and diseases with homozygous for the CFTR Phe508del mutation. Moreover, Elexacaftor (VX-445, HY-111772) is also a CFTR corrector. Elexacaftor-Tezacaftor-Ivacaftor aims at with cystic fibrosis (CF) with at least one Phe508del mutation, often avoids the indication for lung transplantation[1][2][3][4]. |
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In Vitro |
Tezacaftor (2 μM, 24 h) increases the expression level of N1303K-CFTR in HEK293 and CFBE cells[4]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot Analysis[4]
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Clinical Trial |
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Molecular Weight |
520.50 |
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Formula |
C26H27F3N2O6 |
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CAS No. |
1152311-62-0 |
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Appearance |
Solid |
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Color |
White to yellow |
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SMILES |
O=C(C1(C2=CC=C(OC(F)(F)O3)C3=C2)CC1)NC4=CC5=C(N(C[C@@H](O)CO)C(C(C)(C)CO)=C5)C=C4F |
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Shipping | Room temperature in continental US; may vary elsewhere. |
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Storage |
4°C, stored under nitrogen *In solvent : -80°C, 1 year; -20°C, 6 months (stored under nitrogen) |
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Solvent & Solubility |
In Vitro:
DMSO : 50 mg/mL (96.06 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO
+
%
+
%
Tween-80
+
%
Saline
The co-solvents required include: DMSO,
. All of co-solvents are available by MedChemExpress (MCE).
, Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration:
mg/mL
Method for preparing stock solution:
mg
drug dissolved in
μL
DMSO (Stock solution concentration: mg/mL).
*In solvent : -80°C, 1 year; -20°C, 6 months (stored under nitrogen)
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take
μL DMSO stock solution, add
μL .
μL , mix evenly, next add
μL Tween 80, mix evenly, then add
μL Saline.
If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
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Purity & Documentation |
Purity: 99.94% |
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References |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months (stored under nitrogen). When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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DMSO | 1 mM | 1.9212 mL | 9.6061 mL | 19.2123 mL | 48.0307 mL |
5 mM | 0.3842 mL | 1.9212 mL | 3.8425 mL | 9.6061 mL | |
10 mM | 0.1921 mL | 0.9606 mL | 1.9212 mL | 4.8031 mL | |
15 mM | 0.1281 mL | 0.6404 mL | 1.2808 mL | 3.2020 mL | |
20 mM | 0.0961 mL | 0.4803 mL | 0.9606 mL | 2.4015 mL | |
25 mM | 0.0768 mL | 0.3842 mL | 0.7685 mL | 1.9212 mL | |
30 mM | 0.0640 mL | 0.3202 mL | 0.6404 mL | 1.6010 mL | |
40 mM | 0.0480 mL | 0.2402 mL | 0.4803 mL | 1.2008 mL | |
50 mM | 0.0384 mL | 0.1921 mL | 0.3842 mL | 0.9606 mL | |
60 mM | 0.0320 mL | 0.1601 mL | 0.3202 mL | 0.8005 mL | |
80 mM | 0.0240 mL | 0.1201 mL | 0.2402 mL | 0.6004 mL |
Tezacaftor Related Classifications
- Membrane Transporter/Ion Channel
- CFTR