MYB Split FISH Probe
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- More Files
Hybridization position of the probes on the chromosome:
Hybridization position of the probes on the chromosome:
- Specifications
Product Description
Labeled FISH probes for identification of gene split using Fluorescent In Situ Hybridization Technique. ().
Probe 1
Name: MYB(Texas Red)
Size: Approximately 500kb
Fluorophore: Texas Red
Location: 6q22-23Probe 2
Name: MYB(FITC)
Size: Approximately 780kb
Fluorophore: FITC
Location: 6q22-23Probe Gap
The length of overlap between two probes is approximately 20 kb.
Origin
Human
Source
Genomic DNA
Reactivity
Human
Form
Liquid
Notice
We strongly recommend the customer to use FFPE FISH PreTreatment Kit 1 (Catalog #: KA2375 or KA2691) for the pretreatment of Formalin-Fixed Paraffin-Embedded (FFPE) tissue sections.
Regulation Status
For research use only (RUO)
Quality Control Testing
Representative images of normal human cell (lymphocyte) stain with the dual color FISH probe. The left image is chromosomes at metaphase, and the right image is an interphase nucleus.
Supplied Product
DAPI Counterstain (1500 ng/mL ) 125 uL for each 100 uL FISH Probe
Storage Instruction
Store at 4°C in the dark.
Note
Hybridization position of the probes on the chromosome:
- Applications
Fluorescent In Situ Hybridization (Cell)
- Gene Info — MYB
Entrez GeneID
4602Gene Name
MYB
Gene Alias
Cmyb, c-myb, c-myb_CDS, efg
Gene Description
v-myb myeloblastosis viral oncogene homolog (avian)
Omim ID
189990Gene Ontology
HyperlinkGene Summary
This gene encodes a transcription factor that is a member of the MYB family of transcription factor genes. The protein contains three domains, an N-terminal DNA-binding domain, a central transcriptional activation domain and a C-terminal domain involved in transcriptional repression. This protein plays an essential role in the regulation of hematopoiesis and may play a role in tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq
Other Designations
Avian myeloblastosis viral (v-myb) oncogene homolog|OTTHUMP00000017258|c-myb protein (140 AA)|c-myb10A_CDS|c-myb13A_CDS|c-myb14A_CDS|c-myb8B_CDS|v-myb avian myeloblastosis viral oncogene homolog|v-myb myeloblastosis viral oncogene homolog
- Interactomes
- Diseases
- Publication Reference
- Nuclear immunoreactivity of BLM-s, a pro-apoptotic BCL-2 family member, is specifically detected in salivary adenoid cystic carcinoma.
Tsai MS, Hsieh MS, Huang HY, Huang PH.
Human Pathology 2018 Sep; [Epub].
Application：Func, Human, Human salivary adenoid cystic carcinoma.
- Strong SOX10 expression in HPV-related multiphenotypic sinonasal carcinoma: report of six new cases validated by high-risk HPV mRNA in situ hybridization test.
Hsieh MS, Lee YH, Jin YT, Huang WC.
Human Pathology 2018 Jul; [Epub].
Application：FISH-P, Human, HPV-related multiphenotypic sinonasal carcinoma.
- Adenoid Cystic Carcinoma of the Lacrimal Gland: MYB Gene Activation, Genomic Imbalances, and Clinical Characteristics.
von Holstein SL, Fehr A, Persson M, Therkildsen MH, Prause JU, Heegaard S, Stenman G.
Ophthalmology 2013 Oct; 120(10):2130.
Application：FISH, Human, Adenoid cystic carcinoma.
- Nuclear immunoreactivity of BLM-s, a pro-apoptotic BCL-2 family member, is specifically detected in salivary adenoid cystic carcinoma.
