Our MKL1 break apart probe is designed to detect MKL1 translocations. The probe comes labeled in green and orange, but can be customized to meet your needs.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
Gene Summary
The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Gene Details
Gene Symbol: MKL1
Gene Name: Megakaryoblastic Leukemia (translocation) 1
Chromosome: CHR22: 40806291-41032690
Locus: 22q13.1-q13.2