- Specifications
Product Description
Mouse monoclonal antibody raised against native ITGAM.
Immunogen
Native purified ITGAM from rheumatoid synovial cells and human monocytes.
Host
Mouse
Reactivity
Human
Specificity
Specificity human CD11b/Mac-1alpha
Form
Liquid
Conjugation
Biotin
Isotype
IgG1
Recommend Usage
Flow Cytometry (10 ul/106 cells)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store in the dark at 4°C. Do not freeze.
Avoid prolonged exposure to light.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Applications
Immunohistochemistry (Frozen sections)
Flow Cytometry
- Gene Info — ITGAM
Entrez GeneID
3684Gene Name
ITGAM
Gene Alias
CD11B, CR3A, MAC-1, MAC1A, MGC117044, MO1A, SLEB6
Gene Description
integrin, alpha M (complement component 3 receptor 3 subunit)
Omim ID
120980Gene Ontology
HyperlinkGene Summary
This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
antigen CD11b (p170)|complement component receptor 3, alpha|integrin alpha M|macrophage antigen alpha polypeptide|neutrophil adherence receptor alpha-M subunit
- Interactomes
- Pathways
- Diseases
- Publication Reference
- Overlapping, but not identical, sites are involved in the recognition of C3bi, neutrophil inhibitory factor, and adhesive ligands by the alphaMbeta2 integrin.
Zhang L, Plow EF.
The Journal of Biological Chemistry 1996 Jul; 271(30):18211.
- Integrins as promiscuous signal transduction devices.
Petty HR, Todd RF 3rd.
Immunology Today 1996 May; 17(5):209.
Application：Flow Cyt, Human, Cancer, Mammalian cells.
- The Mac-1 and p150,95 beta 2 integrins bind denatured proteins to mediate leukocyte cell-substrate adhesion.
G E Davis.
Experimental Cell Research 1992 Jun; 200(2):242.
- Overlapping, but not identical, sites are involved in the recognition of C3bi, neutrophil inhibitory factor, and adhesive ligands by the alphaMbeta2 integrin.
ITGAM monoclonal antibody, clone ICRF44 (Biotin)
Cat# MAB6031
Size : 100Reactions