Isradipine [75695-93-1]
Cat# HY-B0233-10mg
Size : 10mg
Brand : MedChemExpress
Isradipine (PN 200-110) is an orally active L-type calcium channel blocker. Isradipine, as a powerful peripheral vasodilator, is a dihydropyridine calcium antagonist with selective actions on the heart as well as the peripheral circulation. Isradipine is a potentially viable neuroprotective agent for Parkinson's disease.
For research use only. We do not sell to patients.
Isradipine Chemical Structure
CAS No. : 75695-93-1
This product is a controlled substance and not for sale in your territory.
Description |
Isradipine (PN 200-110) is an orally active L-type calcium channel blocker. Isradipine, as a powerful peripheral vasodilator, is a dihydropyridine calcium antagonist with selective actions on the heart as well as the peripheral circulation. Isradipine is a potentially viable neuroprotective agent for Parkinson's disease[1][2][3]. |
IC50 & Target |
L-type calcium channel[1][2] |
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In Vitro |
Isradipine has much higher (>40 fold) affinity for Cav1.3 channels as well as good brain bioavailability. Isradipine has nearly equal potency at Cav1.2 and Cav1.3 channels[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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In Vivo |
Isradipine (0.1~3 mg/kg; p.o.) makes sodium excretion increase in a dose-dependent manner[3]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Clinical Trial |
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Molecular Weight |
371.39 |
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Formula |
C19H21N3O5 |
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CAS No. |
75695-93-1 |
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Appearance |
Solid |
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Color |
Light yellow to yellow |
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SMILES |
O=C(C1=C(C)NC(C)=C(C(OC(C)C)=O)C1C2=CC=CC3=NON=C23)OC |
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Shipping | Room temperature in continental US; may vary elsewhere. |
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Storage |
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Solvent & Solubility |
In Vitro:
DMSO : ≥ 100 mg/mL (269.26 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) *"≥" means soluble, but saturation unknown. Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO
+
%
+
%
Tween-80
+
%
Saline
The co-solvents required include: DMSO,
. All of co-solvents are available by MedChemExpress (MCE).
, Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration:
mg/mL
Method for preparing stock solution:
mg
drug dissolved in
μL
DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take
μL DMSO stock solution, add
μL .
μL , mix evenly, next add
μL Tween 80, mix evenly, then add
μL Saline.
If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
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Purity & Documentation |
Purity: 99.89% |
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References |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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DMSO | 1 mM | 2.6926 mL | 13.4629 mL | 26.9259 mL | 67.3147 mL |
5 mM | 0.5385 mL | 2.6926 mL | 5.3852 mL | 13.4629 mL | |
10 mM | 0.2693 mL | 1.3463 mL | 2.6926 mL | 6.7315 mL | |
15 mM | 0.1795 mL | 0.8975 mL | 1.7951 mL | 4.4876 mL | |
20 mM | 0.1346 mL | 0.6731 mL | 1.3463 mL | 3.3657 mL | |
25 mM | 0.1077 mL | 0.5385 mL | 1.0770 mL | 2.6926 mL | |
30 mM | 0.0898 mL | 0.4488 mL | 0.8975 mL | 2.2438 mL | |
40 mM | 0.0673 mL | 0.3366 mL | 0.6731 mL | 1.6829 mL | |
50 mM | 0.0539 mL | 0.2693 mL | 0.5385 mL | 1.3463 mL | |
60 mM | 0.0449 mL | 0.2244 mL | 0.4488 mL | 1.1219 mL | |
80 mM | 0.0337 mL | 0.1683 mL | 0.3366 mL | 0.8414 mL | |
100 mM | 0.0269 mL | 0.1346 mL | 0.2693 mL | 0.6731 mL |