Guanosine 5'-triphosphate (trisodium salt) [36051-31-7]
Cat# HY-12695-100mg
Size : 100mg
Brand : MedChemExpress
Guanosine 5'-triphosphate (5'-GTP) trisodium salt is a G protein (G proteins) signaling activator and a high-energy precursor in the biosynthesis of nucleotide units in DNA and RNA. Guanosine 5'-triphosphate trisodium salt can promote myogenic cell differentiation by upregulating miRNA (miR133a, miR133b) and myogenic regulatory factor expression, and by inducing human myogenic precursor cells to release exosomes containing guanosine molecules. Guanosine-5'-triphosphate disodium salt holds promise for research in biosynthesis and skeletal muscle regeneration.
For research use only. We do not sell to patients.
Guanosine 5'-triphosphate trisodium salt Chemical Structure
CAS No. : 36051-31-7
This product is a controlled substance and not for sale in your territory.
Based on 4 publication(s) in Google Scholar
Other Forms of Guanosine 5'-triphosphate trisodium salt:
- Guanosine-5'-triphosphate disodium salt In-stock
- Guanosine 5'-triphosphate trisodium salt hydrate Get quote
Description |
Guanosine 5'-triphosphate (5'-GTP) trisodium salt is a G protein (G proteins) signaling activator and a high-energy precursor in the biosynthesis of nucleotide units in DNA and RNA. Guanosine 5'-triphosphate trisodium salt can promote myogenic cell differentiation by upregulating miRNA (miR133a, miR133b) and myogenic regulatory factor expression, and by inducing human myogenic precursor cells to release exosomes containing guanosine molecules. Guanosine-5'-triphosphate disodium salt holds promise for research in biosynthesis and skeletal muscle regeneration[1][2]. |
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IC50 & Target |
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In Vitro |
Guanosine-5'-triphosphate disodium salt (500 μM, 24 h) significantly promoted the upregulation of miR133a, miR133b, and myogenic regulatory factors Myogenin in differentiated human myogenic precursor cells (MPCs)[2]. Guanosine-5'-triphosphate disodium salt (500 μM, 24 h) can induce the release of exosomes from human myogenic precursor cells[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. RT-PCR[2]
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Molecular Weight |
589.13 |
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Formula |
C10H13N5Na3O14P3 |
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CAS No. |
36051-31-7 |
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Appearance |
Solid |
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Color |
White to off-white |
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SMILES |
O=P(OP(OP(O)(OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C=NC3=C2NC(N)=NC3=O)O1)=O)([O])=O)(O[Na])O[Na].[Na] |
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Structure Classification |
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Initial Source |
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Shipping | Room temperature in continental US; may vary elsewhere. |
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Storage |
-20°C, stored under nitrogen, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture) |
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Solvent & Solubility |
In Vitro:
H2O : 125 mg/mL (212.18 mM; Need ultrasonic) Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
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Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles. * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration:
mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
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Purity & Documentation | |||||||||||||
References |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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H2O | 1 mM | 1.6974 mL | 8.4871 mL | 16.9742 mL | 42.4355 mL |
5 mM | 0.3395 mL | 1.6974 mL | 3.3948 mL | 8.4871 mL | |
10 mM | 0.1697 mL | 0.8487 mL | 1.6974 mL | 4.2435 mL | |
15 mM | 0.1132 mL | 0.5658 mL | 1.1316 mL | 2.8290 mL | |
20 mM | 0.0849 mL | 0.4244 mL | 0.8487 mL | 2.1218 mL | |
25 mM | 0.0679 mL | 0.3395 mL | 0.6790 mL | 1.6974 mL | |
30 mM | 0.0566 mL | 0.2829 mL | 0.5658 mL | 1.4145 mL | |
40 mM | 0.0424 mL | 0.2122 mL | 0.4244 mL | 1.0609 mL | |
50 mM | 0.0339 mL | 0.1697 mL | 0.3395 mL | 0.8487 mL | |
60 mM | 0.0283 mL | 0.1415 mL | 0.2829 mL | 0.7073 mL | |
80 mM | 0.0212 mL | 0.1061 mL | 0.2122 mL | 0.5304 mL | |
100 mM | 0.0170 mL | 0.0849 mL | 0.1697 mL | 0.4244 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Guanosine 5'-triphosphate trisodium salt Related Classifications
- Oligonucleotides
- Nucleotides and their Analogs
- Others
- Metabolic Enzyme/Protease Cell Cycle/DNA Damage
- Endogenous Metabolite DNA/RNA Synthesis