- More Files
- Specifications
Product Description
Rabbit polyclonal antibody raised against synthetic phosphopeptide of BIRC5.
Immunogen
Synthetic phosphopeptide corresponding to residues surrounding T34 of BIRC5.
Host
Rabbit
Reactivity
Bovine, Cat, Dog, Human, Mouse, Pig, Primates
Specificity
This antibody is specific to phosphorylated survivin.
Form
Liquid
Recommend Usage
Immunocytochemistry (1:50-1:200)
Immunofluorescence (1:50-1:200)
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris-citrate/phosphate buffer, pH 7.0-8.0 (0.09% sodium azide)
Storage Instruction
Store at 4°C. Do not freeze.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Applications
Western Blot
Immunocytochemistry
Immunofluorescence
- Gene Info — BIRC5
Entrez GeneID
332Gene Name
BIRC5
Gene Alias
API4, EPR-1
Gene Description
baculoviral IAP repeat-containing 5
Omim ID
603352Gene Ontology
HyperlinkGene Summary
This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors yet low in adult tissues. Antisense transcripts are involved in the regulation of this gene's expression. At least four transcript variants encoding distinct isoforms have been found for this gene, but the full-length natures of only three of them have been determined. [provided by RefSeq
Other Designations
apoptosis inhibitor 4|baculoviral IAP repeat-containing protein 5|survivin variant 3 alpha
- Interactomes
- Pathways
- Diseases
- Publication Reference
- Survivin, a member of the inhibitor of apoptosis family, is induced by photodynamic therapy and is a target for improving treatment response.
Ferrario A, Rucker N, Wong S, Luna M, Gomer CJ.
Cancer Research 2007 May; 67(10):4989.
Application：WB, Human, Mouse, Human BT-474, Mouse BA, YUSAC2/T34A-C4 cells.
- Rapid induction of mitochondrial events and caspase-independent apoptosis in Survivin-targeted melanoma cells.
Liu T, Brouha B, Grossman D.
Oncogene 2004 Jan; 23(1):39.
- Survivin, a member of the inhibitor of apoptosis family, is induced by photodynamic therapy and is a target for improving treatment response.