General Info
Host: | Rabbit |
Applications: | WB |
Reactivity: | Human/Mouse |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-PAX4 (50-200) is suitable for use in Western Blot research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
Purification: | Affinity purification |
Dilution Range: | WB 1:500-1:2000 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Information
Gene Symbol: | PAX4Uniprot ID=PAX4_HUMAN" |
Immunogen Region: | 50-200 |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 50-200 of human PAX4 (NP_006184.2). |
Immunogen Sequence: | LGRYYRTGVLEPKGIGGSKP RLATPPVVARIAQLKGECPA LFAWEIQRQLCAEGLCTQDK TPSVSSINRVLRALQEDQGL PCTRLRSPAVLAPAVLTPHS GSETPRGTHPGTGHRNRTIF SPSQAEALEKEFQRGQYPDS VARGKLATATS |
Description
Function | Plays an important role in the differentiation and development of pancreatic islet beta cells. Transcriptional repressor that binds to a common element in the glucagon, insulin and somatostatin promoters. Competes with PAX6 for this same promoter binding site. Isoform 2 appears to be a dominant negative form antagonizing PAX4 transcriptional activity. |
Protein Name | Paired Box Protein Pax-4 |
Cellular Localisation | Nucleus |
Alternative Antibody Names | Anti-Paired Box Protein Pax-4 antibodyAnti-PAX4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance