Anti-GABRB2 antibody (1-50) {FITC}

Clonality:	Polyclonal
Conjugation:	FITC
Isotype:	IgG
Purification:	Affinity Purified
Concentration:	0.55-0.75 µg/µl
Dilution Range:	WB: 1:500 DB: 1:10, 000 ELISA: 1:10, 000 IP: 1:150 IHC: 1:100
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	GABRB2
Gene ID:	2561
Uniprot ID:	GBRB2_HUMAN
Immunogen Region:	1-50
Specificity:	Will label various GABA B subunit 2 variants.
Immunogen:	Synthetic peptide taken within amino acid region 1-50 on human gamma-aminobutyric acid A receptor beta 2 protein.

Tissue Specificity	Isoform 1 and isoform 2 show reduced expression in schizophrenic brain. Isoform 3 shows increased expression in schizophrenic and bipolar disorder brains while isoform 4 shows reduced expression.
Post Translational Modifications	Glycosylated.
Function	Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain. Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel. The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer. The alpha1/beta2/gamma2 receptor and the alpha2/beta2/gamma2 receptor exhibit synaptogenic activity. Functions also as histamine receptor and mediates cellular responses to histamine.
Protein Name	Gamma-Aminobutyric Acid Receptor Subunit Beta-2 Gaba(A Receptor Subunit Beta-2
Database Links	Reactome: R-HSA-1236394 Reactome: R-HSA-977443
Cellular Localisation	Postsynaptic Cell Membrane Multi-Pass Membrane Protein Cell Membrane Cytoplasmic Vesicle Membrane
Alternative Antibody Names	Anti-Gamma-Aminobutyric Acid Receptor Subunit Beta-2 antibody Anti-Gaba(A Receptor Subunit Beta-2 antibody Anti-GABRB2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance