Y27632 2 HCl [129830-38-2]
Cat# AOB3877-10
Size : 10mg
Brand : AOBIOUS
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Data sheet
| Molecular Formula | C14H23Cl2N3O |
| Molecular Weight | 320.26 |
| CAS Numbers | 129830-38-2 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| Synonym | Y27632; Y-27632; Y 27632; Y27632 HCl; Y27632 dihydrochloride |
| IUPAC/Chemical Name | (1R,4r)-4-((R)-1-aminoethyl)-N-(pyridin-4-yl)cyclohexanecarboxamide dihydrochloride |
| InChl Key | IDDDVXIUIXWAGJ-LJDSMOQUSA-N |
| InChl Code | InChI=1S/C14H21N3O.2ClH/c1-10(15)11-2-4-12(5-3-11)14(18)17-13-6-8-16-9-7-13;;/h6-12H,2-5,15H2,1H3,(H,16,17,18);2*1H/t10-,11-,12-;;/m1../s1 |
| SMILES Code | O=C([C@H]1CC[C@H]([C@H](N)C)CC1)NC2=CC=NC=C2.16Cl.16Cl |
| References | 1) Yang CY, et al., Effects of Y27632 on aqueous humor outflow facility with changes in hydrodynamic pattern and morphology in human eyes. Invest Ophthalmol Vis Sci. 2013 Aug 28;54(8):5859-70. doi: 10.1167/iovs.12-10930. PubMed PMID: 23920374; PubMed Central PMCID: PMC3757907. 2) Gandham VD, et al., Effects of Y27632 on keratinocyte procurement and wound healing. Clin Exp Dermatol. 2013 Oct;38(7):782-6. doi: 10.1111/ced.12067. Epub 2013 May 16. PubMed PMID: 23675999; PubMed Central PMCID: PMC3748215. |
More info
A selective ROCK1 (p160ROCK) inhibitor with Ki of 140 nM, exhibits >200-fold selectivity over other kinases, including PKC, cAMP-dependent protein kinase, MLCK and PAK.