General Info
| Applications: | ELISA |
| Reactivity: | Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: | 0.36ng/mL |
| Detection Limit: | 0.781-50ng/mL |
| Short Description: | This ALAS1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in rat cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: | Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: | 4.5 hrs |
Information
| Gene Symbol: | Alas1 |
| Gene ID: | 65155 |
| Uniprot ID: | HEM1_RAT |
| Sample Type: | tissue homogenates or other biological fluids. |
Description
| Tissue Specificity | Expressed in the liver, kidney, brain and testis. |
| Post Translational Modifications | In normoxia, is hydroxylated at Pro-578, promoting interaction with VHL, initiating ubiquitination and subsequent degradation via the proteasome. Ubiquitinated.in normoxia following hydroxylation and interaction with VHL, leading to its subsequent degradation via the proteasome. |
| Function | Catalyzes the pyridoxal 5'-phosphate (PLP)-dependent condensation of succinyl-CoA and glycine to form aminolevulinic acid (ALA), with CoA and CO2 as by-products. |
| Protein Name | 5-Aminolevulinate Synthase - Non-Specific - MitochondrialAlas-H5-Aminolevulinic Acid Synthase 1Delta-Ala Synthase 1Delta-Aminolevulinate Synthase 1 |
| Database Links | Reactome: R-RNO-189451 |
| Cellular Localisation | Mitochondrion Inner MembranePeripheral Membrane ProteinLocalizes To The Matrix Side Of The Mitochondrion Inner Membrane |
| Alternative ELISA Names | 5-Aminolevulinate Synthase - Non-Specific - Mitochondrial ELISA kitAlas-H ELISA kit5-Aminolevulinic Acid Synthase 1 ELISA kitDelta-Ala Synthase 1 ELISA kitDelta-Aminolevulinate Synthase 1 ELISA kitAlas1 ELISA kit |
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Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance