Reagents and instruments for immunology, cell biology and molecular biology.

PTCH1 Polyclonal Antibody

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Cat# E-AB-10571-60

Size : 60uL

Brand : Elabscience

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Verified Samples	Verified Samples in WB: Hela, Mouse lung Verified Samples in IHC: Human ovarian cancer, Human thyroid cancer
Dilution	WB 1:500-1:2000, IHC 1:50-1:200
Isotype	IgG
Host	Rabbit
Reactivity	Human, Mouse
Applications	WB, IHC
Clonality	Polyclonal
Immunogen	Recombinant protein of human PTCH1
Abbre	PTCH1
Synonyms	BCNS, HPE7, NBCCS, PTC, PTC1, PTCH, PTCH11
Swissprot	Q13635
Calculated MW	161 kDa
Cellular Localization	Nucleus, Plasma Membrane, caveola, ciliary membrane, plasma membrane, Other locations: axonal growth cone, dendritic growth cone, endocytic vesicle membrane, integral component of membrane, intracellular membrane-bounded organelle, midbody, perinuclear region of cytoplasm, postsynaptic density.
Concentration	0.5 mg/mL
Buffer	Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Purification Method	Affinity purification
Research Areas	Cancer, Cell Biology, Neuroscience, Stem Cells
Conjugation	Unconjugated
Storage	Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Shipping	The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
background	This gene encodes a member of the patched gene family. The encoded protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis, as well as the desert hedgehog and indian hedgehog proteins. This gene functions as a tumor suppressor. Mutations of this gene have been associated with basal cell nevus syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinomas of the bladder, as well as holoprosencephaly. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences and biological validity cannot be determined currently.

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E-IR-R217	2-step plus Poly-HRP Anti Mouse/Rabbit IgG Detection System (with DAB solution)	50mL , 18mL , 6mL , 3mL
E-IR-R220	Super Plus™ Highly Sensitive and Rapid Immunohistochemical Kit (pH9.0)	10mL , 3mL
E-IR-R221	Super Plus™ Highly Sensitive and Rapid Immunohistochemical Kit (pH6.0)	10mL , 3mL
E-IR-R304A	Western Blot Detection Kit	50Assays
E-IR-R304B	High Accuracy and Absorbability Western Blot Detection Kit	50Assays