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> Okadaic acid [78111-17-8]

Okadaic acid [78111-17-8]

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Cat# 10-2091-20ug

Size : 20ug

Brand : Focus Biomolecules

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Okadaic acid | Protein phosphatase inhibitor

CAS:
78111-17-8
Catalog Number:
10-2091
Activity:
Protein phosphatase inhibitor
Source:
Isolated from marine dinoflagellates
Molecular Weight:
805.00
Molecular Formula:
C44H68O13
Solubility:
Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 5 mg/ml).
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT

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20 ug$35.00
100 ug$140.00
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Okadaic acid (78111-17-8) is a naturally occurring polyether marine toxin. Potent and selective inhibitor of protein phosphatases inhibiting PP2A completely at 1 nM and PP1 at higher concentrations, while PP2C is not inhibited. It is an extremely useful tool for studying cellular protein phosphorylation.2 Induces apoptosis in a variety of cell types.3 Okadaic acid activates atypical protein kinase isotypes and induces insulin-like effects in adipocytes.4

Caution: SKIN IRRITANT, TUMOR PROMOTOR. Avoid contact.

References/Citations:

1) Cohen et al. (1990), Okadaic acid: a new probe for the study of cellular regulation;  Trends Biochem. Sci., 15 98
2) Hardie et al. (1991), Use of okadaic acid to inhibit protein phosphatases in intact cells;  Clin. Methods Enzymol., 201 469
3) Haneji et al. (2013), Okadaic acid activates the PKR pathway and induces apoptosis through PKR stimulation in MG63 osteoblast-like cells;  J. Oncol., 42 1904
4) Standaert et al. (1999), Okadaic acid activates atypical protein kinase C (zeta/lambda) In rats and 3T3/L1 adipocytes. An apparent requirement for activation of Glut4 translocation and glucose transport;  J. Biol. Chem, 274 14074

CAS:
78111-17-8
Catalog Number:
10-2091
Activity:
Protein phosphatase inhibitor
Source:
Isolated from marine dinoflagellates
Molecular Weight:
805.00
Molecular Formula:
C44H68O13
Solubility:
Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 5 mg/ml).
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Download Product Data Sheet

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a restocking/refund fee

Okadaic acid (78111-17-8) is a naturally occurring polyether marine toxin. Potent and selective inhibitor of protein phosphatases inhibiting PP2A completely at 1 nM and PP1 at higher concentrations, while PP2C is not inhibited. It is an extremely useful tool for studying cellular protein phosphorylation.2 Induces apoptosis in a variety of cell types.3 Okadaic acid activates atypical protein kinase isotypes and induces insulin-like effects in adipocytes.4

Caution: SKIN IRRITANT, TUMOR PROMOTOR. Avoid contact.

References/Citations:

1) Cohen et al. (1990), Okadaic acid: a new probe for the study of cellular regulation;  Trends Biochem. Sci., 15 98
2) Hardie et al. (1991), Use of okadaic acid to inhibit protein phosphatases in intact cells;  Clin. Methods Enzymol., 201 469
3) Haneji et al. (2013), Okadaic acid activates the PKR pathway and induces apoptosis through PKR stimulation in MG63 osteoblast-like cells;  J. Oncol., 42 1904
4) Standaert et al. (1999), Okadaic acid activates atypical protein kinase C (zeta/lambda) In rats and 3T3/L1 adipocytes. An apparent requirement for activation of Glut4 translocation and glucose transport;  J. Biol. Chem, 274 14074