Mouse MCL1 (Myeloid Cell Leukemia Sequence 1, Bcl2 Related) Sandwich ELISA Kit

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	Mcl1
Gene ID:	17210
Uniprot ID:	MCL1_MOUSE
Sample Type:	serum, plasma, tissue homogenates or other biological fluids.

Tissue Specificity
Post Translational Modifications	Cleaved by CASP3 during apoptosis, yielding a pro-apoptotic C-terminal fragment. Rapidly degraded in the absence of phosphorylation in the PEST region. Phosphorylated on Ser-140, by GSK3, in response to IL3/interleukin-3 withdrawal. Phosphorylation at Ser-140 induces ubiquitination and proteasomal degradation, abrogating the anti-apoptotic activity. Treatment with taxol or okadaic acid induces phosphorylation on additional sites. Ubiquitinated. Ubiquitination is induced by phosphorylation at Ser-140. Deubiquitinated by USP20.leading to increased stability.
Function	Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 2 has antiapoptotic activity.
Protein Name	Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 Homolog Bcl-2-Related Protein Eat/Mcl1
Database Links
Cellular Localisation	Membrane Single-Pass Membrane Protein Cytoplasm Mitochondrion Nucleus Nucleoplasm Cytoplasmic Associated With Mitochondria
Alternative ELISA Names	Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 Homolog ELISA kit Bcl-2-Related Protein Eat/Mcl1 ELISA kit Mcl1 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance