Size : 5g
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Fluconazole (hydrate) is a triazole antifungal drug used in the treatment and prevention of superficial and systemic fungal infections.
Cell lines
Pathogenic Candida species
Preparation method
The solubility of this compound in DMSO is ≥16.35mg/mL. General tips for obtaining a higher concentration: Please warm the tube at 37 ℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months.
Reacting condition
100 mg/l
Applications
In tests done in standard mycological media, the compound had minimal inhibitory concentrations against pathogenic Candida species that were usually in excess of 100 mg/1. Fluconazole inhibited branching and hyphal development in C. albicans at concentrations as low as 10−6 M (0.3 mg/l), but miconazole and ketoconazole were still active in these tests at concentrations 100 times lower than this.
References:
[1]. Odds FC, Cheesman SL, Abbott AB. Antifungal effects of fluconazole (UK 49858), a new triazole antifungal, in vitro. J Antimicrob Chemother. 1986 Oct;18(4):473-8. PubMed PMID: 3021710.
