Flecainide (acetate) [54143-56-5]
Cat# HY-17429-10mg
Size : 10mg
Brand : MedChemExpress
Flecainide acetate (R-818) is a class 1C antiarrhythmic agent especially used for the management of supraventricular arrhythmia; works by blocking the Nav1.5 sodium channel in the heart, causing prolongation of the cardiac action potential.
For research use only. We do not sell to patients.
Flecainide acetate Chemical Structure
CAS No. : 54143-56-5
This product is a controlled substance and not for sale in your territory.
Based on 1 publication(s) in Google Scholar
Other Forms of Flecainide acetate:
- Flecainide-d4 acetate In-stock
- Flecainide In-stock
View All Sodium Channel Isoform Specific Products:
Description |
Flecainide acetate (R-818) is a class 1C antiarrhythmic agent especially used for the management of supraventricular arrhythmia; works by blocking the Nav1.5 sodium channel in the heart, causing prolongation of the cardiac action potential. |
||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IC50 & Target[1] |
|
||||||||||||
In Vitro |
Flecainide is a class 1C antiarrhythmic drug especially used for the management of supraventricular arrhythmia. Flecainide works by blocking the Nav1.5 sodium channel in the heart, causing prolongation of the cardiac action potential. in vitro: Under the current-clamp condition, flecainide (1-100 microM) prolonged the action potential duration at both the early and the late phases of repolarization in a concentration-dependent manner without affecting the resting membrane potential [1]. At a holding potential (HP) of -120 mV, flecainide use-dependently blocked WT and G1306E I(Na) equally but was more potent on R1448C channels. For WT, the extent of block depended on a holding voltage more negative than the activation threshold, being greater at -90 mV as compared to -120 and -180 mV [2]. in vivo: Flecainide (80-130 mg/m(2) orally) resulted in termination of the tachycardia in all 8 patients. Acute pharmacological termination of arrhythmia occurred with oral flecainide loading in 1 and temporarily with intravenous esmolol loading in 1 patient. Adjuvant therapy in form of propranolol was used in 5 and digoxin in 2 [3]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
||||||||||||
Clinical Trial |
|
||||||||||||
Molecular Weight |
474.39 |
||||||||||||
Formula |
C19H24F6N2O5 |
||||||||||||
CAS No. |
54143-56-5 |
||||||||||||
Appearance |
Solid |
||||||||||||
Color |
White to off-white |
||||||||||||
SMILES |
O=C(NCC1NCCCC1)C2=CC(OCC(F)(F)F)=CC=C2OCC(F)(F)F.CC(O)=O |
||||||||||||
Shipping | Room temperature in continental US; may vary elsewhere. |
||||||||||||
Storage |
4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
||||||||||||
Solvent & Solubility |
In Vitro:
DMSO : 50 mg/mL (105.40 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) H2O : 20 mg/mL (42.16 mM; Need ultrasonic) Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles. * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration:
mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
|
||||||||||||
Purity & Documentation |
Purity: 98.98% |
||||||||||||
References |
|
Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
---|
H2O / DMSO | 1 mM | 2.1080 mL | 10.5399 mL | 21.0797 mL | 52.6993 mL |
5 mM | 0.4216 mL | 2.1080 mL | 4.2159 mL | 10.5399 mL | |
10 mM | 0.2108 mL | 1.0540 mL | 2.1080 mL | 5.2699 mL | |
15 mM | 0.1405 mL | 0.7027 mL | 1.4053 mL | 3.5133 mL | |
20 mM | 0.1054 mL | 0.5270 mL | 1.0540 mL | 2.6350 mL | |
25 mM | 0.0843 mL | 0.4216 mL | 0.8432 mL | 2.1080 mL | |
30 mM | 0.0703 mL | 0.3513 mL | 0.7027 mL | 1.7566 mL | |
40 mM | 0.0527 mL | 0.2635 mL | 0.5270 mL | 1.3175 mL | |
DMSO | 50 mM | 0.0422 mL | 0.2108 mL | 0.4216 mL | 1.0540 mL |
60 mM | 0.0351 mL | 0.1757 mL | 0.3513 mL | 0.8783 mL | |
80 mM | 0.0263 mL | 0.1317 mL | 0.2635 mL | 0.6587 mL | |
100 mM | 0.0211 mL | 0.1054 mL | 0.2108 mL | 0.5270 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Flecainide acetate Related Classifications
- Membrane Transporter/Ion Channel
- Sodium Channel