DR6 Polyclonal Antibody
Cat# bs-7678R-20ul
Size : 20ul
Brand : Bioss
DR6 Polyclonal Antibody
Applications
Reactivity
Predicted Reactivity
Overview | |
Catalog # | bs-7678R |
Product Name | DR6 Polyclonal Antibody |
Applications | WB, ELISA, IHC-P, IHC-F, IF(IHC-P), IF(IHC-F), IF(ICC), ICC |
Reactivity | Mouse, Rat |
Predicted Reactivity | Human, Dog, Cow, Horse, Chicken, Rabbit |
Specifications | |
Conjugation | Unconjugated |
Host | Rabbit |
Source | KLH conjugated synthetic peptide derived from human DR6 |
Immunogen Range | 101-200/655 |
Clonality | Polyclonal |
Isotype | IgG |
Concentration | 1ug/ul |
Purification | Purified by Protein A. |
Storage Buffer | 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
Storage Condition | Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
Target | |
Gene ID | 27242 |
Swiss Prot | O75509 |
Subcellular location | Cell membrane |
Synonyms | DR6; CD358; BM-018; Tumor necrosis factor receptor superfamily member 21; Death receptor 6; TNFRSF21; UNQ437/PRO868 |
Background | Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B. Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm. Plays a role in neuronal apoptosis, including apoptosis in response to amyloid peptides derived from APP, and is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21; this triggers caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). Negatively regulates oligodendrocyte survival, maturation and myelination. Plays a role in signaling cascades triggered by stimulation of T-cell receptors, in the adaptive immune response and in the regulation of T-cell differentiation and proliferation. Negatively regulates T-cell responses and the release of cytokines such as IL4, IL5, IL10, IL13 and IFNG by Th2 cells. Negatively regulates the production of IgG, IgM and IgM in response to antigens. May inhibit the activation of JNK in response to T-cell stimulation. |
Application Dilution | |
WB | 1:300-5000 |
ELISA | 1:500-1000 |
IHC-P | 1:200-400 |
IHC-F | 1:100-500 |
IF(IHC-P) | 1:50-200 |
IF(IHC-F) | 1:50-200 |
IF(ICC) | 1:50-200 |
ICC | 1:100-500 |