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> Colchicine-d3 [1217625-62-1]

Colchicine-d3 [1217625-62-1]

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Cat# TRC-C640002-1MG

Size : 1mg

Brand : Toronto Research Chemicals

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Colchicine-d3

Product Code

TRC-C640002

CAS Number

1217625-62-1

Product Format

Neat

Molecular Formula

C22 2H3 H22 N O6

Molecular Weight

402.46

Product Type

Stable Isotope Labelled

Unlabelled CAS Number

64-86-8

Purity

>95% (HPLC)

Documentation

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Product Information

Chemical Data

Analyte Name

Colchicine 7-acetamide-d3

CAS Number

1217625-62-1

Molecular Formula

C22 2H3 H22 N O6

Molecular Weight

402.46

Accurate Mass

402.187

SMILES

[2H]C([2H])([2H])C(=O)N[C@H]1CCc2cc(OC)c(OC)c(OC)c2C3=CC=C(OC)C(=O)C=C13

InChI

InChI=1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1/i1D3

IUPAC

2,2,2-trideuterio-N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzopmheptalen-7-yl]acetamide

Unlabelled CAS Number

64-86-8

SIL Type

Deuterium

Product Data

Storage Temperature

-20°C

Shipping Temperature

Room Temperature

Country of Origin

CANADA

Product Type

Stable Isotope Labelled

Product Format

Neat

Purity

>95% (HPLC)

Product Description

An isotopically labelled antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.

References: Lunduena, R.F., et al.: Curr. Opin. Cell Biol., 4, 53 (1992), Ceccatelli, S., et al.: Neuroreport, 8, 3779 (1997), Want, T.H., et al.: J. Biol. Chem., 273, 4928 (1998), Andreu, J.M., et al.: Biochemistry, 37, 8356 (1998), Jordan, A., et al.: Med. Res. Rev., 18, 259 (1998),