General Info
| Host: | Rabbit |
| Applications: | ELISA/IP/WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-THAP1 (150-210) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Biotin |
| Isotype: | IgG |
| Purification: | Affinity Purified |
| Concentration: | 0.5-1.5 µg/µl |
| Dilution Range: | WB: 1:500ELISA: 1:10, 000IP: 1:200IHC: 1:50-1:150ICC: 1:50-1:150 |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Information
| Gene Symbol: | THAP1 |
| Gene ID: | 55145 |
| Uniprot ID: | THAP1_HUMAN |
| Immunogen Region: | 150-210 |
| Immunogen: | Synthetic peptide taken within amino acid region 150-210 on human THAP domain-containing protein 1. |
Description
| Tissue Specificity | Highly expressed in heart, skeletal muscle, kidney and liver. Weaker expression in brain and placenta. |
| Function | DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-ATNTNNGTGGCAAGT-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. May also have pro-apoptotic activity by potentiating both serum-withdrawal and TNF-induced apoptosis. |
| Protein Name | Thap Domain-Containing Protein 1 |
| Cellular Localisation | NucleusNucleoplasmPml Body |
| Alternative Antibody Names | Anti-Thap Domain-Containing Protein 1 antibodyAnti-THAP1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance