Anti-RAPGEF3 antibody (526-541) {Biotin}

Clonality:	Polyclonal
Conjugation:	Biotin
Isotype:	IgG
Purification:	Affinity Purified
Concentration:	0.59 µg/µl
Dilution Range:	WB: 1:500 DB: 1:10, 000 ELISA: 1:10, 000 IHC: 1:200 ICC: 1:200 IF: 1:200 CFM: 1:200
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	RAPGEF3
Gene ID:	10411
Uniprot ID:	RPGF3_HUMAN
Immunogen Region:	526-541
Specificity:	Does not cross react with Epac2.
Immunogen:	Synthetic peptide corresponding to amino acids 526-541 of Epac1 protein, peptide was covalently modified. Sequence DHSVLTLQLQLPVTASVR

Tissue Specificity	Widely expressed with highest levels in adult kidney, heart, thyroid and brain, and fetal kidney.
Function	Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho-mediated signaling. Required for the actin rearrangement at cell-cell junctions, such as stress fibers and junctional actin.
Protein Name	Rap Guanine Nucleotide Exchange Factor 3 Exchange Factor Directly Activated By Camp 1 Exchange Protein Directly Activated By Camp 1 Epac 1 Rap1 Guanine-Nucleotide-Exchange Factor Directly Activated By Camp Camp-Regulated Guanine Nucleotide Exchange Factor I Camp-Gefi
Database Links	Reactome: R-HSA-354192 Reactome: R-HSA-381676 Reactome: R-HSA-392517 Reactome: R-HSA-422356
Cellular Localisation	Endomembrane System
Alternative Antibody Names	Anti-Rap Guanine Nucleotide Exchange Factor 3 antibody Anti-Exchange Factor Directly Activated By Camp 1 antibody Anti-Exchange Protein Directly Activated By Camp 1 antibody Anti-Epac 1 antibody Anti-Rap1 Guanine-Nucleotide-Exchange Factor Directly Activated By Camp antibody Anti-Camp-Regulated Guanine Nucleotide Exchange Factor I antibody Anti-Camp-Gefi antibody Anti-RAPGEF3 antibody Anti-CGEF1 antibody Anti-EPAC antibody Anti-EPAC1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance