General Info
| Host: | Mouse |
| Applications: | WB/IHC-P/IP/IHC-F/ELISA/IF |
| Reactivity: | Human/D.melanogaster/Hamster/Mouse/Rat/Xenopus |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Mouse monoclonal antibody anti-Poly Polymerase is suitable for use in Western Blot, Immunohistochemistry, Immunoprecipitation, Immunohistochemistry, ELISA and Immunofluorescence research applications. |
| Clonality: | Monoclonal |
| Clone ID: | A6.4.12 |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Formulation: | PBS with 0.09% sodium azide |
| Concentration: | 1.0 mg/mL |
| Storage Instruction: | Store at 2-8°C upon receipt. |
Information
| Immunogen: | Human PARP-1 |
Description
| Background | Mouse anti poly (ADP-ribose) polymerase 1 antibody, clone A6.4.12 recognizes poly (ADP-ribose) polymerase 1 (PARP-1) , a ~116 kDa nuclear enzyme, cleaved during apoptosis (Soldani et al. 2002). PARP-1, a caretaker enzyme, is involved in DNA damage repair (Langelier et al. 2013) , plays roles in diabetes pathophysiology (Andreone et al. 2012) and tumour proliferation (Rosado et al 2013.).As well as protecting cells from genomic instability, PARP-1 is involved in the development of both inflammatory and immune responses, and cell death by apoptosis and necrosis (Erdélyi et al. 2005). Mouse anti poly (ADP-ribose) polymerase 1 antibody, clone A6.4.12, targets PARP-1, an enzyme which represents a promising target for new developments in therapeutic treatment of immune mediated diseases (Rosado et al. 2013). PARP-1 has considerable potential for delivering selective tumour cell killing while sparing normal cells (Pinton et al. 2013). |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance