Anti-PDE10A antibody (250-325) {Biotin}

Clonality:	Polyclonal
Conjugation:	Biotin
Isotype:	IgG
Purification:	Affinity Purified
Concentration:	0.7 µg/µl
Dilution Range:	WB: 1:500 DB: 1:10, 000 ELISA: 1:10, 000 IP: 1:200 IHC: 1:100-1:150 ICC: 1:100-1:150 IF: 1:100-1:150 CFM: 1:100-1:150
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	PDE10A
Gene ID:	10846
Uniprot ID:	PDE10_HUMAN
Immunogen Region:	250-325
Specificity:	This antibody has no cross-reactivity against any other PDE family members tested so far. This antibody will detect all PDE10A variants and subtypes.
Immunogen:	Synthetic peptide (Human) taken against a common sequence near the 250-325 amino acids downstream of N terminal region of PDE10A. Synthetic MAP.

Tissue Specificity	Abundant in the putamen and caudate nucleus regions of brain and testis, moderately expressed in the thyroid gland, pituitary gland, thalamus and cerebellum.
Post Translational Modifications	Isoform PDE10A2: Phosphorylated on Thr-16.
Function	Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate. May play a critical role in regulating cAMP and cGMP levels in the striatum, a region of the brain that contributes to the control of movement and cognition.
Protein Name	Camp And Camp-Inhibited Cgmp 3' -5'-Cyclic Phosphodiesterase 10a
Database Links	Reactome: R-HSA-418457 Reactome: R-HSA-418555
Cellular Localisation	Cytoplasm Cytosol
Alternative Antibody Names	Anti-Camp And Camp-Inhibited Cgmp 3' -5'-Cyclic Phosphodiesterase 10a antibody Anti-PDE10A antibody

Information sourced from Uniprot.org

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