General Info
| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-CYP4X1 (190-290) is suitable for use in Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Information
| Gene Symbol: | CYP4X1 |
| Gene ID: | 260293 |
| Uniprot ID: | CP4X1_HUMAN |
| Immunogen Region: | 190-290 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 190-290 of human CYP4X1 (NP_828847.1). |
| Immunogen Sequence: | DIIMKCAFSKETNCQTNSTH DPYAKAIFELSKIIFHRLYS LLYHSDIIFKLSPQGYRFQK LSRVLNQYTDTIIQERKKSL QAGVKQDNTPKRKYQDFLDI V |
Description
| Tissue Specificity | Expressed in brain, heart, kidney and skin and, at lower levels, in skeletal muscle and liver. In the brain, high levels are detected in amygdala and lower levels in globus pallidus and cerebellum. In the heart, very high levels in aorta, but very low levels in other heart regions. Also expressed in breast, prostate and colon. |
| Function | A cytochrome P450 monooxygenase that selectively catalyzes the epoxidation of the last double bond of the arachidonoyl moiety of anandamide, potentially modulating endocannabinoid signaling. Has no hydroxylase activity toward various fatty acids, steroids and prostaglandins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR.NADPH-ferrihemoprotein reductase). |
| Protein Name | Cytochrome P450 4x1Cypivx1 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Membrane ProteinMicrosome Membrane |
| Alternative Antibody Names | Anti-Cytochrome P450 4x1 antibodyAnti-Cypivx1 antibodyAnti-CYP4X1 antibodyAnti-UNQ1929 antibodyAnti-PRO4404 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance