General Info
Host: | Mouse |
Applications: | WB/IHC/IF/ELISA |
Reactivity: | Human/Monkey |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Mouse monoclonal antibody anti-CREB-regulated transcription coactivator 3 is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
Clonality: | Monoclonal |
Clone ID: | 5G9 |
Conjugation: | Unconjugated |
Isotype: | IgG1 |
Formulation: | Liquid in PBS containing 0.03% Sodium Azide, 0.5% BSA, 50% Glycerol. |
Purification: | Affinity purification |
Dilution Range: | WB 1:500-1:2000IHC 1:200-1:1000IF 1:200-1:1000ELISA 1:10000 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Information
Gene Symbol: | CRTC3 |
Gene ID: | 64784 |
Uniprot ID: | CRTC3_HUMAN |
Specificity: | TORC3 Monoclonal Antibody detects endogenous levels of TORC3 protein. |
Immunogen: | Purified recombinant fragment of human TORC3 expressed in E. Coli. |
Description
Post Translational Modifications | Phosphorylation/dephosphorylation states of Ser-273 are required for regulating transduction of CREB activity. CRTCs/TORCs are inactive when phosphorylated, and active when dephosphorylated at this site. May be phosphorylated at Ser-391 by MAPK3/ERK1 and/or MAPK1/ERK2 or by some cyclin-dependent kinases such as CDK1,CDK2 or CDK5. Following adenylyl cyclase activation, dephosphorylated at Ser-162 and Ser-273 resulting in its dissociation from 14-3-3 proteins probably promoting CRTC3 translocation into the nucleus. |
Function | Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). |
Protein Name | Creb-Regulated Transcription Coactivator 3Transducer Of Regulated Camp Response Element-Binding Protein 3Torc-3Transducer Of Creb Protein 3 |
Database Links | Reactome: R-HSA-2151201Reactome: R-HSA-400253Reactome: R-HSA-9707616 |
Cellular Localisation | NucleusCytoplasmAppears To Be Mainly NuclearTranslocates To The Nucleus Following Adenylyl Cyclase Or Map Kinase Activation |
Alternative Antibody Names | Anti-Creb-Regulated Transcription Coactivator 3 antibodyAnti-Transducer Of Regulated Camp Response Element-Binding Protein 3 antibodyAnti-Torc-3 antibodyAnti-Transducer Of Creb Protein 3 antibodyAnti-CRTC3 antibodyAnti-TORC3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance