Rabbit Polyclonal Anti-PTEN (Tumor Suppressor Protein) Polyclonal Antibody
Cat# 24-5728-RBP1-1ml
Size : 1ml
Brand : American Research Products
Anti-PTEN (Tumor Suppressor Protein), Monoclonal Antibody
Category: Antibodies
Catalog
24-5728-RBP1
| Product Name | Anti-PTEN (Tumor Suppressor Protein), Monoclonal Antibody |
|---|---|
| Description | Recognizes a protein of 55kDa, which is identified as PTEN. PTEN is one of the most commonly lost tumor suppressors in human cancer; in fact, up to 70% of men with prostate cancer are estimated to have lost a copy of the PTEN gene at the time of diagnosis. During tumor development, mutations and deletions of PTEN occur that inactivate its enzymatic activity leading to increased cell proliferation and reduced cell death. Frequent genetic inactivation of PTEN occurs in glioblastoma, endometrial cancer, and prostate cancer; and reduced expression is found in many other tumor types such as lung and breast cancer. In breast and prostate cancer, loss of PTEN expression has been shown to correlate positively with advanced stage. Furthermore, PTEN mutation also causes a variety of inherited predispositions to cancer. |
| Synonyms | Bannayan Zonana syndrome (BZS), DEC, GLM2, ITGA 2, MHAM, Multiple hamartoma (Cowden syndrome), Mutated in Mutiple Advanced Cancers 1 (MMAC1), Phosphatase and tensin like protein, Phosphatidylinositol 345 trisphosphate 3 phosphatase, Platelet antigen BR, PTEN1, Tensin homolog, TEP1, VLA 2 Receptor Alpha Subunit |
| Host | Rabbit |
| Clonality | Monoclonal |
| Immunogen | Recombinant full-length human PTEN protein |
| Isotype | Ig |
| Reactivity | Human |
| Applications | FC, IF, WB |
| Form | 200ug/ml of Ab purified from rabbit anti-serum by Protein A. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA at 1.0mg/ml. |
| Gene Id | 5728 |
| Uniprot | P60484 |
| Storage | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required. |
| References | Steck P, et al. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers . Nature Genetics. 1997;15 (4): 356-62. 2 |
| Supplier | ARP |
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