Rabbit Polyclonal Anti-beta-Catenin (p120) Polyclonal Antibody
Cat# 24-1499-RBP1-100ul
Size : 100ul
Brand : American Research Products
Anti-beta-Catenin (p120), Monoclonal Antibody
Category: Antibodies
Catalog
24-1499-RBP1
| Product Name | Anti-beta-Catenin (p120), Monoclonal Antibody |
|---|---|
| Description | Beta-catenin associates with the cytoplasmic portion of E-cadherin, which is necessary for the function of E-cadherin as an adhesion molecule. In normal tissues, beta-catenin is localized to the membrane of epithelial cells, consistent with its role in the cell adhesion complex. In breast ductal neoplasia, beta-catenin is usually localized in cellular membranes. However, in lobular neoplasia, a marked redistribution of beta-catenin throughout the cytoplasm results in a diffuse cytoplasmic pattern. Immuno-staining of beta-catenin and E-cadherin is helps in the accurate identification of ductal and lobular neoplasms, including a distinction between low-grade ductal carcinoma in situ (DCIS) and lobular carcinoma. Additionally, some rectal and gastric adenocarcinomas demonstrate diffuse cytoplasmic beta-catenin staining and a lack of membranous staining, mimicking the staining pattern observed with lobular breast carcinomas. |
| Synonyms | Cadherin associated protein), beta 1 88kDa, Catenin beta-1, CATNB, CHBCAT, CTNNB1 |
| Host | Rabbit |
| Clonality | Monoclonal |
| Immunogen | A synthetic peptide from the middle of beta-Catenin (p120) protein |
| Isotype | IgG |
| Reactivity | Human, Mouse |
| Applications | FC, IF, IHC, WB |
| Form | 200ug/ml of Ab purified from rabbit anti-serum by Protein A. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA at 1.0mg/ml. |
| Gene Id | 1499 |
| Uniprot | P35222 |
| Storage | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required. |
| References | Dabbs DJ et. al. Am J Surg Path. 2007;31:427-437.Sarrio D et. al. Oncogene. 2004;23:3272-3283.Mastracci TL et. al. Mod Path. 2005;18:741-751 |
| Supplier | ARP |
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