NeuroD1 (1C9) Monoclonal Antibody
Cat# bsm-52948R
Size : 100ul
Brand : Bioss
NeuroD1 (1C9) Monoclonal Antibody
Lane 1: Human Brain; Lane 2: SH-SY5Y Cells; Probed with NeuroD1 (1C9) Monoclonal Antibody (bsm-52948R) at 1:500 overnight at 4\u00b0C followed by a conjugated secondary antibody for 60 minutes at 37\u00b0C.
Applications
Reactivity
| Overview | |
| Catalog # | bsm-52948R |
| Product Name | NeuroD1 (1C9) Monoclonal Antibody |
| Applications | WB, IHC-P |
| Reactivity | Human, Mouse, Rat |
| Specifications | |
| Conjugation | Unconjugated |
| Host | Rabbit |
| Source | N terminal human NeuroD1 |
| Immunogen Range | 1-50/356 |
| Clonality | Monoclonal |
| Clone # | 1C9 |
| Isotype | IgG |
| Concentration | 1ug/ul |
| Purification | Purified by Protein A. |
| Storage Buffer | Aqueous buffered solution containing 1xTBS (pH7.4), 1%BSA, 40%Glycerol and 0.05% Sodium Azide. |
| Storage Condition | Store at -20°C for 12 months. |
| Target | |
| Gene ID | 4760 |
| Swiss Prot | Q13562 |
| Subcellular location | Nucleus |
| Synonyms | Neurogenic differentiation factor 1; Class A basic helix-loop-helix protein 3; NeuroD; NeuroD1; bHLHa3; NEUROD1; BETA2; BHF-1; MODY6. |
| Background | Acts as a transcriptional activator: mediates transcriptional activation by binding to E box-containing promoter consensus core sequences 5'-CANNTG-3'. Associates with the p300/CBP transcription coactivator complex to stimulate transcription of the secretin gene as well as the gene encoding the cyclin-dependent kinase inhibitor CDKN1A. Contributes to the regulation of several cell differentiation pathways, like those that promote the formation of early retinal ganglion cells, inner ear sensory neurons, granule cells forming either the cerebellum or the dentate gyrus cell layer of the hippocampus, endocrine islet cells of the pancreas and enteroendocrine cells of the small intestine. Together with PAX6 or SIX3, is required for the regulation of amacrine cell fate specification. Also required for dendrite morphogenesis and maintenance in the cerebellar cortex. Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis. |
| Application Dilution | |
| WB | 1:300-5000 |
| IHC-P | 1:200-400 |