Mouse Monoclonal Anti-NKX2.2 (Neuroendocrine & Ewing Sarcoma Marker) [Clone SPM564]
Cat# NB-36-00575X-P0
Size : 20ug
Brand : Neo Biotech
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NKX2.2 (Neuroendocrine & Ewing Sarcoma Marker) Antibody [SPM564]
Formalin-fixed, paraffin-embedded human Ewing's sarcoma stained with NKX2.2 Monoclonal Antibody (SPM564).
Formalin-fixed, paraffin-embedded human Pancreas stained with NKX2.2 Monoclonal Antibody (SPM564).
Applications & Dilutions
Summary
Expression of NKX2.2 has been found in neuroendocrine tumors of the gut, making it a potential marker for the study of gastrointestinal neuroendocrine tumors. More recently, NKX2.2 protein was identified as a target of EWS-FLI-1, the fusion protein specific to Ewing sarcoma, and was shown to be differentially upregulated in Ewing sarcoma on the basis of array-based gene expression analysis. It acts as a valuable marker for Ewing sarcoma, with a sensitivity of 93% and a specificity of 89%, and aids in the differential diagnosis of small round cell tumors.
Product Properties & Targets
Functions
- Transcriptional activator involved in the development of insulin-producting beta cells in the endocrine pancreas (By similarity). May also be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Binds to elements within the NEUROD1 promoter (By similarity).
Key References
- Wang, Y.C. et al. (2009) Endocr Relat Cancer 16, 267-79.
- Yoshida A et. al. Am J Surg Pathol. 2012;36(7):993-9.
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