Mouse Monoclonal Anti-Blood Group Antigen A (CD173) [Clone HE-10]
Cat# NB-36-00249-P0
Size : 20ug
Brand : Neo Biotech
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Blood Group Antigen A (CD173) Antibody [HE-10]
Formalin-fixed, paraffin-embedded human Colorectal Carcinoma stained with Blood Group Antigen A Monoclonal Antibody (HE-10)
Applications & Dilutions
Summary
This MAb preferably reacts with determinants of chain A and H type 3(Gal1-3GalNAc-R) and 4 (Gal1-3GalNAc-R), but not with type 1 and 2 chain structures. It is not reactive with immuno-dominant A trisaccharide. This MAb is applicable for tissue staining in tumor patients with blood groups A and AB. It shows a highly heterogeneous reactivity in human colon tumor tissue and adjacent mucosa. Blood-group antigens are generally defined as molecules formed by sequential addition of saccharides to the carbohydrate side chains of lipids and proteins detected on erythrocytes and certain epithelial cells. The A, B and H antigens are reported to undergo modulation during malignant cellular transformation. Blood group related antigens represent a group of carbohydrate determinants carried on both glycolipids and glycoproteins. They are usually mucin-type, and are detected on erythrocytes, certain epithelial cells, and in secretions of certain individuals. Sixteen genetically and biosynthetically distinct but inter-related specificities belong to this group of antigens, including A, B, H, Lewis A, Lewis B, Lewis X, Lewis Y, and precursor type 1 chain antigens.
Product Properties & Targets
Functions
- This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity.
Key References
- Nemec M et al. Murine monoclonal antibodies to human A erythrocytes: differential reactivity with N-acetyl-D-galactosamine. Vox Sang 52:125-8 (1987).
- J. Vaak et al. (1989) Detection of blood group A antigen expression in human colon cancer using monoclonal antibodies with different specificities. Neoplasma, 36: 479-487.
PubMed Links
- https://pubmed.ncbi.nlm.nih.gov/2104828/
- https://pubmed.ncbi.nlm.nih.gov/2333095/
- https://pubmed.ncbi.nlm.nih.gov/7598760/
- https://pubmed.ncbi.nlm.nih.gov/7779106/
- https://pubmed.ncbi.nlm.nih.gov/16533287/
- https://pubmed.ncbi.nlm.nih.gov/17764507/
- https://pubmed.ncbi.nlm.nih.gov/18513251/
- https://pubmed.ncbi.nlm.nih.gov/15489334/
- https://pubmed.ncbi.nlm.nih.gov/12829588/
- https://pubmed.ncbi.nlm.nih.gov/8839869/
- https://pubmed.ncbi.nlm.nih.gov/9800297/
- https://pubmed.ncbi.nlm.nih.gov/15104652/
- https://pubmed.ncbi.nlm.nih.gov/1449469/
- https://pubmed.ncbi.nlm.nih.gov/2121736/
- https://pubmed.ncbi.nlm.nih.gov/10462501/
- https://pubmed.ncbi.nlm.nih.gov/12198488/
- https://pubmed.ncbi.nlm.nih.gov/12529355/
- https://pubmed.ncbi.nlm.nih.gov/12972418/
- https://pubmed.ncbi.nlm.nih.gov/15475562/
- https://pubmed.ncbi.nlm.nih.gov/16326711/
- https://pubmed.ncbi.nlm.nih.gov/17259183/
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