iMatrix-511 SILK Stem Cell Culture Substrate
NP892-021
Brand: iMatrix
An alternative iMatrix-511 that is xeno-free, recombinant Laminin-511 E8 Fragment expressed in silkworm for promoting adherence and culture of human iPS cells.
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Product Information
iMatrix-511 SILK is a highly purified and refined laminin-511 E8 fragments, produced in Silkworms.
iMatrix-511 SILK features make it an ideal matrix for pluripotent stem cell culture:
- Promotes greater stem cell adhesion than all other matrix proteins that have been tested
- Easy to use (liquid format)
- E8 fragments retain integrin binding specificity and capacity, and display higher potency than natural Laminin-511
- Equivalent performance, but lower cost than the legacy iMatrix-511 product
Laminin is localized to the basement membrane and plays a key role in cell adhesion and proliferation. Laminin-511 (α5, β1 laminin) binds to integrin α6β1 to promote cell signaling. Laminin-511 provides an ideal matrix for the proliferation of a wide variety of cell types including stem and iPS cells.
iMatrix-511 SILK is functionally equivalent to iMatrix-511 (Cat. No. NP892-011). The only difference is the expression system used for bioproduction. The iMatrix-511 SILK product is produced in recombinant silkworm cocoon, while iMatrix-511 is produced in CHO-S cells. Both are E8 fragments that have been purified using the same processes.
Matrixome company name and logo and iMatrix brand name are the property of Matrixome Corp., Japan.
Specifications Sheets:
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Additional Publications
- Liu L-P; Li Y-M; Guo N-N; LI S; Ma X; Zhang Y-X; Gao Y; Huang J-L; Zheng D-X; Wang L-Y; Xu H; Hui L; Zheng Y-W. Therapeutic Potential of Patient iPSC-Derived iMelanocytes in Autologous Transplantation. Cell Reports 27:455-466.e5 (2019).
- Harmanto Y; Maki T; Yakagi Y; Miyamoto S; Takahashi J. Xeno‐free culture for generation of forebrain oligodendrocyte precursor cells from human pluripotent stem cells. J Neuro Res 2019:1-18 (2019).
- Tsujimara T; Takase O; Yoshikawa M; Sano E; Hayashi M; Hoshi K; Takato T; Toyoda A; Okano H; Hishikawa K. Controlling gene activation by enhancers through a drug-inducible topological insulator. bioRxiv http://dx.doi.org/10.1101/534073 (2019).