iFSP1 [150651-39-1]
Cat# T11631-10mg
Size : 10mg
Brand : TargetMol
iFSP1
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Purity:99.74%
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COA HPLC HNMR
iFSP1
Catalog No. T11631Cas No. 150651-39-1
iFSP1, a potent, selective, and glutathione-independent ferroptosis suppressor protein 1 (FSP1) (AIFM2) inhibitor with an EC50 of 103 nM, sensitizes diverse human cancer cell lines to ferroptosis inducers like (1S,3R)-RSL3. It uniquely triggers ferroptosis in GPX4-knockout cells overexpressing FSP1.
With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs. Pack Size | |
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
Description | iFSP1, a potent, selective, and glutathione-independent ferroptosis suppressor protein 1 (FSP1) (AIFM2) inhibitor with an EC50 of 103 nM, sensitizes diverse human cancer cell lines to ferroptosis inducers like (1S,3R)-RSL3. It uniquely triggers ferroptosis in GPX4-knockout cells overexpressing FSP1. |
Targets&IC50 | FSP1:103 nM (EC50) |
In vitro | iFSP1 (0.001-1 μM; 24 hours) is less effective than genetic deletion of FSP1, and its treatment in the FSP1-knockout background does not enhance RSL3-induced ferroptosis. iFSP1 (3 μM; 24 hours) causes significant toxicity of RSL3 in a panel of genetically engineered (FSP1-knockout) human cancer cell lines. AIFM2, now renamed ferroptosis suppressor protein 1 (FSP1), is identified as a previously unrecognized anti-ferroptotic gene. iFSP1 (0.001-1 μM; 24 hours) inhibits the growth of Gpx4-knockout cells in a dose-dependent manner but does not affect wild type cells. Treatment with the ferroptosis inhibitor Lip-1 protects GPX4-knockout cells from iFSP1-induced ferroptosis. |
Molecular Weight | 323.35 |
Formula | C20H13N5 |
Cas No. | 150651-39-1 |
Storage | Powder: -20°C for 3 years | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 25 mg/mL (77.32 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSO
main solution, add 300 μLPEG300
mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O
mix well and clarify
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
SW620Gpx4-knockoutFSP1FerroptosisiFSP1cancerFSP1-knockoutiFSP-1iFSP 1cellU-373A549RSL3NCl-H1437inhibitInhibitor
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