Atypical Chemokine Receptor D6 Blocking Peptide

Formulation:	Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	Ackr2
Gene ID:	59289
Uniprot ID:	ACKR2_MOUSE
Immunogen Region:	300-378
Specificity:	This blocking peptide is recommended for use in combination with Atypical Chemokine Receptor D6 antibody, STJ500035
Immunogen:	Synthetic peptide taken within amino acid region 300-378 mouse Atypical chemokine receptor 2 protein.

Tissue Specificity	Expressed on apoptotic neutrophils (at protein level).
Post Translational Modifications	Phosphorylated on serine residues in the C-terminal cytoplasmic tail.
Function	Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines including CCL2, CCL3, CCL3L1, CCL4, CCL5, CCL7, CCL8, CCL11, CCL13, CCL17, CCL22, CCL23, CCL24, SCYA2/MCP-1, SCY3/MIP-1-alpha, SCYA5/RANTES and SCYA7/MCP-3. Upon active ligand stimulation, activates a beta-arrestin 1 (ARRB1)-dependent, G protein-independent signaling pathway that results in the phosphorylation of the actin-binding protein cofilin (CFL1) through a RAC1-PAK1-LIMK1 signaling pathway. Activation of this pathway results in up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. By scavenging chemokines in tissues, on the surfaces of lymphatic vessels, and in placenta, plays an essential role in the resolution (termination) of the inflammatory response and in the regulation of adaptive immune responses. Plays a major role in the immune silencing of macrophages during the resolution of inflammation. Acts as a regulator of inflammatory leukocyte interactions with lymphatic endothelial cells (LECs) and is required for immature/mature dendritic cells discrimination by LECs.
Peptide Name	Atypical Chemokine Receptor 2 C-C Chemokine Receptor D6 Chemokine-Binding Protein 2 Chemokine-Binding Protein D6
Database Links	Reactome: R-MMU-380108
Cellular Localisation	Early Endosome Recycling Endosome Cell Membrane Multi-Pass Membrane Protein Predominantly Localizes To Endocytic Vesicles And Upon Stimulation By The Ligand Is Internalized Via Clathrin-Coated Pits Once Internalized The Ligand Dissociates From The Receptor And Is Targeted To Degradation While The Receptor Is Recycled Back To The Cell Membrane
Alternative Peptide Names	Atypical Chemokine Receptor 2 protein C-C Chemokine Receptor D6 protein Chemokine-Binding Protein 2 protein Chemokine-Binding Protein D6 protein Ackr2 protein Ccbp2 protein D6 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance