Anti-RIP140 antibody (50-100) {Biotin}

Clonality:	Polyclonal
Conjugation:	Biotin
Isotype:	IgG
Purification:	Affinity Purified
Concentration:	0.60 µg/µl
Dilution Range:	WB: 1:1, 000 DB: 1:10, 000 ELISA: 1:10, 000 IP: 1:200 IHC: 1:250 ICC: 1:250 IF: 1:250 CFM: 1:250
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	Nrip1
Gene ID:	268903
Uniprot ID:	NRIP1_MOUSE
Immunogen Region:	50-100
Specificity:	Recognizes RIP140 at the N terminal region containing the HDAC binding domain.
Immunogen:	Synthetic peptide taken within amino acid region 50-100 on mouse receptor interacting protein 140.

Tissue Specificity	Expressed in the embryonic placenta. In the adult, expression is strong in the testis and brain. Also expressed at a high level in the white adipose tissue. Expressed constantly but at a weaker level in the adult heart, lung, stomach and kidney. Expressed moderately in the skeletal muscle. Expressed at a low level in the adult spleen, liver and brown adipose tissue. Expressed in the ovary at a high level in granulosa cells and at a lower level in the thecal and interstitial compartments.
Post Translational Modifications	Acetylation abolishes interaction with CTBP1. Phosphorylation enhances interaction with YWHAH. Acetylation regulates its nuclear translocation and corepressive activity.
Function	Modulates transcriptional repression by nuclear hormone receptors such as NR2C1, thyroid hormone receptor and retinoic acid receptor/RARA. Essential for cumulus expansion and follicle rupture during ovulation. Also controls the balance between fat accumulation and energy expenditure. Positive regulator of the circadian clock gene expression: stimulates transcription of BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC. Involved in the regulation of ovarian function. Plays a role in renal development.
Protein Name	Nuclear Receptor-Interacting Protein 1 Nuclear Factor Rip140 Receptor-Interacting Protein 140
Database Links	Reactome: R-MMU-3899300 Reactome: -MMU-9018519
Cellular Localisation	Nucleus
Alternative Antibody Names	Anti-Nuclear Receptor-Interacting Protein 1 antibody Anti-Nuclear Factor Rip140 antibody Anti-Receptor-Interacting Protein 140 antibody Anti-Nrip1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance