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| Gene : | CD81 |
| Gene ID : | 975 |
| Uniprot ID : | P60033 |
| Alternative Name : | CD81, TAPA1, TSPAN28 |
| Immunogen Information : | MOLT-4 (human T-ALL cell line) |
CD81 (TAPA-1), a member of the tetraspanin family, is expressed on virtually all nucleated cells, but above all on germinal center B cells. CD81 forms complexes with other tetraspanin proteins, integrins, coreceptors, MHC class I and II molecules, and influences adhesion, morphology, activation, proliferation and differentiation of B, T and other cells - e.g. in muscles CD81 promotes cell fusion and myotube maintenance. CD81 has been also identified as a receptor for the hepatitis C virus.
| Subcellular location: | Basolateral cell membrane |
| Post transnational modification: | Not glycosylated. |
| Tissue Specificity: | Hematolymphoid, neuroectodermal and mesenchymal tumor cell lines. |
| BioGrid: | 107413. 201 interactions. |
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