Anti-Il10 antibody (Clone: JES5-16E3) {APC}

Clonality:	Monoclonal
Clone ID:	JES5-16E3
Conjugation:	APC
Isotype:	IgG2bk
Formulation:	PBS with 0.05% Proclin300, 1% BSA
Storage Instruction:	Recommend storing between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product.

Gene Symbol:	Il10
Gene ID:	16153
Uniprot ID:	IL10_MOUSE

Function	Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha. Interferes also with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation. In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling.
Protein Name	Interleukin-10 Il-10 Cytokine Synthesis Inhibitory Factor Csif
Cellular Localisation	Secreted
Alternative Antibody Names	Anti-Interleukin-10 antibody Anti-Il-10 antibody Anti-Cytokine Synthesis Inhibitory Factor antibody Anti-Csif antibody Anti-Il10 antibody Anti-Il-10 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance