General Info
| Host: | Rat |
| Applications: | FC |
| Reactivity: | Mouse |
| Note: | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
| Short Description: | Rat monoclonal antibody anti-B-lymphocyte antigen CD19 is suitable for use in Flow Cytometry research applications. |
| Clonality: | Monoclonal |
| Clone ID: | 1D3 |
| Conjugation: | PerCP/Cyanine5.5 |
| Isotype: | IgG2ak |
| Formulation: | PBS with 0.05% Proclin300, 1% BSA |
| Concentration: | 0.2 mg/mL |
| Storage Instruction: | Recommend storing between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product. |
Information
| Gene Symbol: | Cd19 |
| Gene ID: | 12478 |
| Uniprot ID: | CD19_MOUSE |
Description
| Tissue Specificity | Detected on B cells in spleen, bone marrow, thymus and lymph nodes. Detected on peripheral blood lymphocytes (at protein level). |
| Post Translational Modifications | Phosphorylated on tyrosine following B-cell activation. Phosphorylated on tyrosine residues by LYN. Tyrosine residues are phosphorylated sequentially after activation of the B cell receptor. Phosphorylation of Tyr-522 is extremely rapid, followed by phosphorylation at Tyr-402. In contrast, phosphorylation of Tyr-493 appears more slowly and is more transient, returning rapidly to basal levels. |
| Function | Functions as coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens. Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca(2+) stores. Is not required for early steps during B cell differentiation in the blood marrow. Required for normal differentiation of B-1 cells. Required for normal B cell differentiation and proliferation in response to antigen challenges. Required for normal levels of serum immunoglobulins, and for production of high-affinity antibodies in response to antigen challenge. |
| Protein Name | B-Lymphocyte Antigen Cd19Differentiation Antigen Cd19Cd Antigen Cd19 |
| Database Links | Reactome: R-MMU-1257604Reactome: -MMU-198933Reactome: -MMU-6811558Reactome: -MMU-977606Reactome: -MMU-983695 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinMembrane Raft |
| Alternative Antibody Names | Anti-B-Lymphocyte Antigen Cd19 antibodyAnti-Differentiation Antigen Cd19 antibodyAnti-Cd Antigen Cd19 antibodyAnti-Cd19 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance